FUSCO, Giuliana
FUSCO, Giuliana
DIPARTIMENTO DI FARMACIA
Inhibition of alpha-Synuclein Fibril Elongation by Hsp70 Is Governed by a Kinetic Binding Competition between alpha-Synuclein Species
2017 Aprile, Fa; Arosio, P; Fusco, G; Chen, Sw; Kumita, Jr; Dhulesia, A; Tortora, P; Knowles, Tpj; Vendruscolo, M; Dobson, Cm; Cremades, N
Copper(2+) Binding to alpha-Synuclein. Histidine50 Can Form a Ternary Complex with Cu2+ at the N-Terminus but Not a Macrochelate
2019 Tian, Y; Stanyon, Hf; Barritt, Jd; Mayet, U; Patel, P; Karamani, E; Fusco, G; Viles, Jh
Metabolomics fingerprint induced by the intranigral inoculation of exogenous human alpha-synuclein oligomers in a rat model of parkinson's disease
2020 Murgia, F; Atzori, L.; Carboni, E; Santoru, M; Hendren, A; Pisanu, A; Caboni, P; Boi, L; Fusco, G; Carta, A
Extent of N-terminus exposure of monomeric alpha-synuclein determines its aggregation propensity
2020 Stephens, A. D.; Zacharopoulou, M.; Moons, R.; Fusco, G.; Seetaloo, N.; Chiki, A.; Woodhams, P. J.; Mela, I.; Lashuel, H. A.; Phillips, J. J.; De Simone, A.; Sobott, F.; Schierle, G. S. K.
Modeling Parkinson’s disease neuropathology and symptoms by intranigral inoculation of preformed human α-synuclein oligomers
2020 Boi, L.; Pisanu, A.; Palmas, M. F.; Fusco, G.; Carboni, E.; Casu, M. A.; Satta, V.; Scherma, M.; Janda, E.; Mocci, I.; Mulas, G.; Ena, A.; Spiga, S.; Fadda, P.; De Simone, A.; Carta, A. R.
Probing the Origin of the Toxicity of Oligomeric Aggregates of α-Synuclein with Antibodies
2019 Cascella, R.; Perni, M.; Chen, S. W.; Fusco, G.; Cecchi, C.; Vendruscolo, M.; Chiti, F.; Dobson, C. M.; De Simone, A.
Molecular determinants of the interaction of EGCG with ordered and disordered proteins
2018 Fusco, G.; Sanz-Hernandez, M.; Ruggeri, F. S.; Vendruscolo, M.; Dobson, C. M.; De Simone, A.
Structural basis of membrane disruption and cellular toxicity by a-synuclein oligomers
2017 Fusco, G.; Chen, S. W.; Williamson, P. T. F.; Cascella, R.; Perni, M.; Jarvis, J. A.; Cecchi, C.; Vendruscolo, M.; Chiti, F.; Cremades, N.; Ying, L.; Dobson, C. M.; De Simone, A.
Structural Basis for Natural Product Selection and Export by Bacterial ABC Transporters
2018 Romano, M.; Fusco, G.; Choudhury, H. G.; Mehmood, S.; Robinson, C. V.; Zirah, S.; Hegemann, J. D.; Lescop, E.; Marahiel, M. A.; Rebuffat, S.; De Simone, A.; Beis, K.
The N-terminal Acetylation of α-Synuclein Changes the Affinity for Lipid Membranes but not the Structural Properties of the Bound State
2020 Runfola, M.; De Simone, A.; Vendruscolo, M.; Dobson, C. M.; Fusco, G.
A Role of Cholesterol in Modulating the Binding of α-Synuclein to Synaptic-Like Vesicles
2020 Man, W. K.; De Simone, A.; Barritt, J. D.; Vendruscolo, M.; Dobson, C. M.; Fusco, G.
Order and disorder in the physiological membrane binding of α-synuclein
2018 Fusco, G.; Sanz-Hernandez, M.; De Simone, A.
The Toxicity of Misfolded Protein Oligomers Is Independent of Their Secondary Structure
2019 Vivoli Vega, M.; Cascella, R.; Chen, S. W.; Fusco, G.; De Simone, A.; Dobson, C. M.; Cecchi, C.; Chiti, F.
1H, 13C and 15N resonance assignments of human muscle acylphosphatase
2012 Fusco, G.; De Simone, A.; Hsu, S. -T. D.; Bemporad, F.; Vendruscolo, M.; Chiti, F.; Dobson, C. M.
Direct observation of the three regions in α-synuclein that determine its membrane-bound behaviour
2014 Fusco, G.; De Simone, A.; Gopinath, T.; Vostrikov, V.; Vendruscolo, M.; Dobson, C. M.; Veglia, G.
Structural Ensembles of Membrane-bound α-Synuclein Reveal the Molecular Determinants of Synaptic Vesicle Affinity
2016 Fusco, G.; De Simone, A.; Arosio, P.; Vendruscolo, M.; Veglia, G.; Dobson, C. M.
Structural basis of synaptic vesicle assembly promoted by α-synuclein
2016 Fusco, G.; Pape, T.; Stephens, A. D.; Mahou, P.; Costa, A. R.; Kaminski, C. F.; Kaminski Schierle, G. S.; Vendruscolo, M.; Veglia, G.; Dobson, C. M.; De Simone, A.
Conformational recognition of an intrinsically disordered protein
2014 Krieger, J. M.; Fusco, G.; Lewitzky, M.; Simister, P. C.; Marchant, J.; Camilloni, C.; Feller, S. M.; De Simone, A.
C-terminal calcium binding of α-synuclein modulates synaptic vesicle interaction
2018 Lautenschlager, J.; Stephens, A. D.; Fusco, G.; Strohl, F.; Curry, N.; Zacharopoulou, M.; Michel, C. H.; Laine, R.; Nespovitaya, N.; Fantham, M.; Pinotsi, D.; Zago, W.; Fraser, P.; Tandon, A.; St George-Hyslop, P.; Rees, E.; Phillips, J. J.; De Simone, A.; Kaminski, C. F.; Schierle, G. S. K.
The docking of synaptic vesicles on the presynaptic membrane induced by α-synuclein is modulated by lipid composition
2021 Man, W. K.; Tahirbegi, B.; Vrettas, M. D.; Preet, S.; Ying, L.; Vendruscolo, M.; De Simone, A.; Fusco, G.
| Titolo | Tipologia | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|---|
| Inhibition of alpha-Synuclein Fibril Elongation by Hsp70 Is Governed by a Kinetic Binding Competition between alpha-Synuclein Species | 1.1 Articolo in rivista | 2017 | Aprile, Fa; Arosio, P; Fusco, G; Chen, Sw; Kumita, Jr; Dhulesia, A; Tortora, P; Knowles, Tpj; Vendruscolo, M; Dobson, Cm; Cremades, N | |
| Copper(2+) Binding to alpha-Synuclein. Histidine50 Can Form a Ternary Complex with Cu2+ at the N-Terminus but Not a Macrochelate | 1.1 Articolo in rivista | 2019 | Tian, Y; Stanyon, Hf; Barritt, Jd; Mayet, U; Patel, P; Karamani, E; Fusco, G; Viles, Jh | |
| Metabolomics fingerprint induced by the intranigral inoculation of exogenous human alpha-synuclein oligomers in a rat model of parkinson's disease | 1.1 Articolo in rivista | 2020 | Murgia, F; Atzori, L.; Carboni, E; Santoru, M; Hendren, A; Pisanu, A; Caboni, P; Boi, L; Fusco, G; Carta, A | |
| Extent of N-terminus exposure of monomeric alpha-synuclein determines its aggregation propensity | 1.1 Articolo in rivista | 2020 | Stephens, A. D.; Zacharopoulou, M.; Moons, R.; Fusco, G.; Seetaloo, N.; Chiki, A.; Woodhams, P. J.; Mela, I.; Lashuel, H. A.; Phillips, J. J.; De Simone, A.; Sobott, F.; Schierle, G. S. K. | |
| Modeling Parkinson’s disease neuropathology and symptoms by intranigral inoculation of preformed human α-synuclein oligomers | 1.1 Articolo in rivista | 2020 | Boi, L.; Pisanu, A.; Palmas, M. F.; Fusco, G.; Carboni, E.; Casu, M. A.; Satta, V.; Scherma, M.; Janda, E.; Mocci, I.; Mulas, G.; Ena, A.; Spiga, S.; Fadda, P.; De Simone, A.; Carta, A. R. | |
| Probing the Origin of the Toxicity of Oligomeric Aggregates of α-Synuclein with Antibodies | 1.1 Articolo in rivista | 2019 | Cascella, R.; Perni, M.; Chen, S. W.; Fusco, G.; Cecchi, C.; Vendruscolo, M.; Chiti, F.; Dobson, C. M.; De Simone, A. | |
| Molecular determinants of the interaction of EGCG with ordered and disordered proteins | 1.1 Articolo in rivista | 2018 | Fusco, G.; Sanz-Hernandez, M.; Ruggeri, F. S.; Vendruscolo, M.; Dobson, C. M.; De Simone, A. | |
| Structural basis of membrane disruption and cellular toxicity by a-synuclein oligomers | 1.1 Articolo in rivista | 2017 | Fusco, G.; Chen, S. W.; Williamson, P. T. F.; Cascella, R.; Perni, M.; Jarvis, J. A.; Cecchi, C.; Vendruscolo, M.; Chiti, F.; Cremades, N.; Ying, L.; Dobson, C. M.; De Simone, A. | |
| Structural Basis for Natural Product Selection and Export by Bacterial ABC Transporters | 1.1 Articolo in rivista | 2018 | Romano, M.; Fusco, G.; Choudhury, H. G.; Mehmood, S.; Robinson, C. V.; Zirah, S.; Hegemann, J. D.; Lescop, E.; Marahiel, M. A.; Rebuffat, S.; De Simone, A.; Beis, K. | |
| The N-terminal Acetylation of α-Synuclein Changes the Affinity for Lipid Membranes but not the Structural Properties of the Bound State | 1.1 Articolo in rivista | 2020 | Runfola, M.; De Simone, A.; Vendruscolo, M.; Dobson, C. M.; Fusco, G. | |
| A Role of Cholesterol in Modulating the Binding of α-Synuclein to Synaptic-Like Vesicles | 1.1 Articolo in rivista | 2020 | Man, W. K.; De Simone, A.; Barritt, J. D.; Vendruscolo, M.; Dobson, C. M.; Fusco, G. | |
| Order and disorder in the physiological membrane binding of α-synuclein | 1.1 Articolo in rivista | 2018 | Fusco, G.; Sanz-Hernandez, M.; De Simone, A. | |
| The Toxicity of Misfolded Protein Oligomers Is Independent of Their Secondary Structure | 1.1 Articolo in rivista | 2019 | Vivoli Vega, M.; Cascella, R.; Chen, S. W.; Fusco, G.; De Simone, A.; Dobson, C. M.; Cecchi, C.; Chiti, F. | |
| 1H, 13C and 15N resonance assignments of human muscle acylphosphatase | 1.1 Articolo in rivista | 2012 | Fusco, G.; De Simone, A.; Hsu, S. -T. D.; Bemporad, F.; Vendruscolo, M.; Chiti, F.; Dobson, C. M. | |
| Direct observation of the three regions in α-synuclein that determine its membrane-bound behaviour | 1.1 Articolo in rivista | 2014 | Fusco, G.; De Simone, A.; Gopinath, T.; Vostrikov, V.; Vendruscolo, M.; Dobson, C. M.; Veglia, G. | |
| Structural Ensembles of Membrane-bound α-Synuclein Reveal the Molecular Determinants of Synaptic Vesicle Affinity | 1.1 Articolo in rivista | 2016 | Fusco, G.; De Simone, A.; Arosio, P.; Vendruscolo, M.; Veglia, G.; Dobson, C. M. | |
| Structural basis of synaptic vesicle assembly promoted by α-synuclein | 1.1 Articolo in rivista | 2016 | Fusco, G.; Pape, T.; Stephens, A. D.; Mahou, P.; Costa, A. R.; Kaminski, C. F.; Kaminski Schierle, G. S.; Vendruscolo, M.; Veglia, G.; Dobson, C. M.; De Simone, A. | |
| Conformational recognition of an intrinsically disordered protein | 1.1 Articolo in rivista | 2014 | Krieger, J. M.; Fusco, G.; Lewitzky, M.; Simister, P. C.; Marchant, J.; Camilloni, C.; Feller, S. M.; De Simone, A. | |
| C-terminal calcium binding of α-synuclein modulates synaptic vesicle interaction | 1.1 Articolo in rivista | 2018 | Lautenschlager, J.; Stephens, A. D.; Fusco, G.; Strohl, F.; Curry, N.; Zacharopoulou, M.; Michel, C. H.; Laine, R.; Nespovitaya, N.; Fantham, M.; Pinotsi, D.; Zago, W.; Fraser, P.; Tandon, A.; St George-Hyslop, P.; Rees, E.; Phillips, J. J.; De Simone, A.; Kaminski, C. F.; Schierle, G. S. K. | |
| The docking of synaptic vesicles on the presynaptic membrane induced by α-synuclein is modulated by lipid composition | 1.1 Articolo in rivista | 2021 | Man, W. K.; Tahirbegi, B.; Vrettas, M. D.; Preet, S.; Ying, L.; Vendruscolo, M.; De Simone, A.; Fusco, G. |