The invention relates to novel adenyl dinucleotides which are isomers of the dinucleotide Ap2A, having formulae (I) and (II) . The dinucleotides of the invention have antitumour activity, particularly against tumours of haematological origin, such as for example leukaemias and lymphomas. The invention further relates to the use of such dinucleotides as antitumour medicaments. Finally, the invention relates to an enzymatic method for preparing the dinucleotides of formulae (I) and (II) and to an enzymatic assay method for the dinucleotide of formula (I) which is based on its complete conversion to NAD+ .
Novel adenyl dinucleotides with antitumour activity and a method for preparing thereof / Basile, G; Benatti, U; Bruzzone, S; Damonte, G; DE FLORA, A; Fattorusso, Ernesto; Franco, L; Guida, L; TAGLIALATELA SCAFATI, Orazio; Zocchi, E.. - (2006).
Novel adenyl dinucleotides with antitumour activity and a method for preparing thereof
FATTORUSSO, ERNESTO;TAGLIALATELA SCAFATI, ORAZIO;
2006
Abstract
The invention relates to novel adenyl dinucleotides which are isomers of the dinucleotide Ap2A, having formulae (I) and (II) . The dinucleotides of the invention have antitumour activity, particularly against tumours of haematological origin, such as for example leukaemias and lymphomas. The invention further relates to the use of such dinucleotides as antitumour medicaments. Finally, the invention relates to an enzymatic method for preparing the dinucleotides of formulae (I) and (II) and to an enzymatic assay method for the dinucleotide of formula (I) which is based on its complete conversion to NAD+ .I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
