Glycosidase inhibition is expected to be addressed toward specific non-enantioselective, lipophilic enzymes, such as glucocerebrosidases GBA1 and GBA2. In order to assess the effect of chirality and lipophilicity of alkylated iminosugars on the activity/selectivity of such enzymes, some D and L-alkylated iminosugars as 1 and ent-1, in particular those having a gluco-configured pseudo-saccharide moiety (DNJ derivatives) have been synthesized
Evaluation of anti-inflammatory treatments for CF lung disease in murine models of lung infection in vivo / Dechecchi, M. C.; Olioso, D.; Santangelo, A.; Tamanini, A.; Cabrini, G.; Guaragna, A.; D’Alonzo, Daniele.; De Fenza, Maria.; Esposito, Anna.. - (2018). (Intervento presentato al convegno XVI Convention d’Autunno dei ricercatori in Fibrosi Cistica tenutosi a Verona, Italy nel 22-24 Novembre 2018).
Evaluation of anti-inflammatory treatments for CF lung disease in murine models of lung infection in vivo
Guaragna A.;D’Alonzo Daniele.;De Fenza Maria.;Esposito Anna.
2018
Abstract
Glycosidase inhibition is expected to be addressed toward specific non-enantioselective, lipophilic enzymes, such as glucocerebrosidases GBA1 and GBA2. In order to assess the effect of chirality and lipophilicity of alkylated iminosugars on the activity/selectivity of such enzymes, some D and L-alkylated iminosugars as 1 and ent-1, in particular those having a gluco-configured pseudo-saccharide moiety (DNJ derivatives) have been synthesizedI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
