A series of prenylated quinones and corresponding thiazinoquinones ispired to the marine natural product Aplidinone have been synthesised to broaden the knowledge on the antiproliferative effects of these scaffolds. This study afforded a compound with significant cytostatic activity through induction of cell cycle arrest with a significant segregation of cells into G0/G1 phase
Antiproliferative effects of synthetic prenylated quinones and thiazinoquinones inspired by marine natural products / Casertano, M.; Imperatore, C.; Della Sala, G.; Aiello, A.; Menna, M.. - (2020). (Intervento presentato al convegno 1st Virtual Symposium for Young Organic Chemists of Società Chimica Italiana tenutosi a Italy, online nel 3-6 November 2020).
Antiproliferative effects of synthetic prenylated quinones and thiazinoquinones inspired by marine natural products
M. Casertano
;C. Imperatore;G. Della Sala;A. Aiello;M. Menna
2020
Abstract
A series of prenylated quinones and corresponding thiazinoquinones ispired to the marine natural product Aplidinone have been synthesised to broaden the knowledge on the antiproliferative effects of these scaffolds. This study afforded a compound with significant cytostatic activity through induction of cell cycle arrest with a significant segregation of cells into G0/G1 phaseI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
