We have synthesized several cIDPR analogues. In particular, the analogue with the “northern” ribose replaced by a pentyl chain (cpIDP) showed interesting Ca2+ mobilizing activity in the neuronal PC12 cell line. We report here on the total synthesis of a new stable cADPR analogue, in which the “northern” ribose is replaced by a 2”S,3”R dihydroxy pentyl chain. The new mimic elicites Ca2+ ions from intracellular stores in primary cortical neurons as effectively as cADPR.
Total Synthesis of a New Stable Cyclic ADP-Ribose Mimic / D'Errico, S., Greco, F., Falanga, A.P., Tedeschi, V., Piccialli, I., Marzano, M., Terracciano, M., Secondo, A., Roviello Giovanni, N., Borbone, N., Oliviero, G.. - (2021). (The 7th International Electronic Conference on Medicinal Chemistry (ECMC 2021) on line 01-30/11/2021).
Total Synthesis of a New Stable Cyclic ADP-Ribose Mimic
D'Errico Stefano
;Falanga Andrea Patrizia;Piccialli Ilaria;Marzano Maria;Terracciano Monica;Secondo Agnese;Borbone Nicola;Oliviero Giorgia
2021
Abstract
We have synthesized several cIDPR analogues. In particular, the analogue with the “northern” ribose replaced by a pentyl chain (cpIDP) showed interesting Ca2+ mobilizing activity in the neuronal PC12 cell line. We report here on the total synthesis of a new stable cADPR analogue, in which the “northern” ribose is replaced by a 2”S,3”R dihydroxy pentyl chain. The new mimic elicites Ca2+ ions from intracellular stores in primary cortical neurons as effectively as cADPR.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
