IRIS
FRALDI, ALESSANDRO
 Distribuzione geografica
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Continente #
AS - Asia 2.293
EU - Europa 1.937
NA - Nord America 1.860
SA - Sud America 317
AF - Africa 63
OC - Oceania 7
Totale 6.477
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Nazione #
US - Stati Uniti d'America 1.788
SG - Singapore 997
IT - Italia 703
RU - Federazione Russa 664
VN - Vietnam 465
CN - Cina 401
BR - Brasile 254
HK - Hong Kong 175
NL - Olanda 115
DE - Germania 98
FR - Francia 92
FI - Finlandia 54
GB - Regno Unito 52
JP - Giappone 43
IN - India 38
CA - Canada 37
UA - Ucraina 36
KR - Corea 35
IE - Irlanda 32
BD - Bangladesh 24
AR - Argentina 22
MX - Messico 22
ZA - Sudafrica 20
ID - Indonesia 18
TR - Turchia 18
PH - Filippine 17
SE - Svezia 17
CH - Svizzera 14
PL - Polonia 14
AT - Austria 13
IQ - Iraq 12
EC - Ecuador 11
CI - Costa d'Avorio 9
PK - Pakistan 8
AU - Australia 7
MA - Marocco 7
PY - Paraguay 7
TH - Thailandia 7
UY - Uruguay 7
DZ - Algeria 6
ES - Italia 6
SA - Arabia Saudita 6
BE - Belgio 5
KE - Kenya 5
AL - Albania 4
BO - Bolivia 4
LB - Libano 4
LT - Lituania 4
NG - Nigeria 4
PE - Perù 4
TW - Taiwan 4
AZ - Azerbaigian 3
CL - Cile 3
CO - Colombia 3
IR - Iran 3
MY - Malesia 3
NP - Nepal 3
RO - Romania 3
AE - Emirati Arabi Uniti 2
BF - Burkina Faso 2
BG - Bulgaria 2
BH - Bahrain 2
BY - Bielorussia 2
BZ - Belize 2
CR - Costa Rica 2
EG - Egitto 2
ET - Etiopia 2
PA - Panama 2
SN - Senegal 2
TN - Tunisia 2
TT - Trinidad e Tobago 2
VE - Venezuela 2
CU - Cuba 1
CY - Cipro 1
CZ - Repubblica Ceca 1
DK - Danimarca 1
GA - Gabon 1
GE - Georgia 1
GR - Grecia 1
HN - Honduras 1
HR - Croazia 1
IL - Israele 1
KZ - Kazakistan 1
LI - Liechtenstein 1
MD - Moldavia 1
NI - Nicaragua 1
PR - Porto Rico 1
PT - Portogallo 1
SC - Seychelles 1
SY - Repubblica araba siriana 1
VC - Saint Vincent e Grenadine 1
Totale 6.477
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Città #
Singapore 462
San Jose 306
Naples 255
Chandler 167
Hong Kong 161
Moscow 138
Ho Chi Minh City 137
Ashburn 134
Beijing 114
Santa Clara 103
Hanoi 90
Amsterdam 81
Hefei 62
Lauterbourg 49
Napoli 49
Los Angeles 47
Boston 45
The Dalles 38
Tokyo 38
Council Bluffs 37
Jacksonville 37
Princeton 31
São Paulo 31
Millbury 28
Rome 28
New York 26
Milan 25
Munich 25
Buffalo 23
Des Moines 22
Nanjing 22
Dearborn 20
Haiphong 20
Orem 20
Frankfurt am Main 19
Redondo Beach 17
Nuremberg 16
Da Nang 15
Helsinki 15
Johannesburg 15
Lawrence 15
Dallas 14
London 14
Brooklyn 12
Chicago 12
Dong Ket 12
Montreal 12
Ottawa 12
Seoul 12
Houston 11
Biên Hòa 10
Denver 10
Wilmington 10
Atlanta 9
Acerra 8
Fairfield 8
Hải Dương 8
Mexico City 8
Poplar 8
Warsaw 8
Brasília 7
Chennai 7
Falkenstein 7
Phoenix 7
Ribeirão Preto 7
Seo-gu 7
Shenyang 7
Vienna 7
Manchester 6
Nanchang 6
Padova 6
Quảng Ngãi 6
Rio de Janeiro 6
Sarno 6
Seattle 6
Toronto 6
Bangkok 5
Can Tho 5
Domicella 5
Formia 5
Guayaquil 5
Hebei 5
Jeddah 5
Lappeenranta 5
Norwalk 5
Padua 5
Redwood City 5
Salerno 5
Zurich 5
Aversa 4
Belo Horizonte 4
Bengaluru 4
Busan 4
Bắc Giang 4
Capaccio 4
Casablanca 4
Casaluce 4
Caxias do Sul 4
Chengdu 4
Dhaka 4
Totale 3.394
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Nome #
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 598
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) 269
Retinal Degeneration in MPS-IIIA Mouse Model 218
Anti-amyloid treatment is broadly effective in neuronopathic mucopolysaccharidoses and synergizes with gene therapy in MPS-IIIA 192
Treatment of lysosomal storage disorders 175
Phosphorylation-regulated degradation of the tumor-suppressor form of PED by chaperone-mediated autophagy in lung cancer cells 152
Transcription-dependent association of multiple P-TEFb units to a hexim multimer. 148
Brain Targeting in MPS-IIIA 147
Lysosomal dysfunction disrupts presynaptic maintenance and restoration of presynaptic function prevents neurodegeneration in lysosomal storage diseases 146
Inhibition of lipofuscin aggregation by molecular tweezers 145
Multistep, sequential control of the trafficking and function of the multiple sulfatase deficiency gene product, SUMF1 by PDI, ERGIC-53 and ERp44. 143
Functional inactivation of Cdk9 through oligomerization chain reaction. 139
Enhanced Version of Human Sulfamidase Significantly Ameliorates CNS Pathology When Delivered to the MPS-IIIA Mice by AAV-Mediated Intra-CSF Injection 134
Transdermal spinal catheter placement in piglets: Description and validation of the technique. 131
Functional inactivation of Cdk9 through oligomerization chain reaction 129
Access to cerebrospinal fluid in piglets via the cisterna magna: Optimization and description of the technique 129
Altered heparan sulfate metabolism during development triggers dopamine-dependent autistic-behaviours in models of lysosomal storage disorders 127
Glycosaminoglycan levels and structure in a mucopolysaccharidosis IIIA mice and the effect of a highly secreted sulfamidase engineered to cross the blood-brain barrier 126
Cell trafficking of SUMF1 described by functional proteomics experiments 125
Lysosomal fusion and SNARE function are impaired by cholesterol accumulation in lysosomal storage disorders 123
Targeting neuronal proteostasis to treat the CNS in lysosomal storage diseases 121
A highly secreted sulphamidase engineered to cross the blood-brain barrier corrects brain lesions of mice with mucopolysaccharidoses type IIIA. 120
Inhibition of Tat activity by the HEXIM1 protein. 119
A comprehensive map of CNS transduction by eight recombinant adeno-associated virus serotypes upon cerebrospinal fluid administration in pigs 118
MAQ1 and 7K RNA interact with CDK9/Cyclin T complexes in a transcription-dependent manner 115
Intracerebral Administration of Adeno-Associated Viral Vector Serotype rh.10 Carrying Human SGSH and SUMF1 cDNAs in Children with Mucopolysaccharidosis Type IIIA Disease: Results of a Phase I/II Trial. 115
The Amyloid Inhibitor CLR01 Relieves Autophagy and Ameliorates Neuropathology in a Severe Lysosomal Storage Disease 115
A Block of Autophagy in Lysosomal Storage Disorders 114
Therapy of sulfatase deficiencies 108
Impaired parkin-mediated mitochondrial targeting to autophagosomes differentially contributes to tissue pathology in lysosomal storage diseases 107
Distinct regions of cyclinT1 are required for binding to CDK9 and for recruitment to the HIV-1 Tat/TAR complex. 107
Transcriptional activation of lysosomal exocytosis promotes cellular clearance. 105
Enhancing the Therapeutic Potential of Sulfamidase for the Treatment of Mucopolysaccharidosis IIIA 105
Protein aggregation and autophagy dysfunction: new lessons from mucopolysaccharidoses 105
Transcription-dependent association of multiple positive transcription elongation factor units to a HEXIM multimer. 104
Autophagy contributes to inflammation in patients with TNFR-associated periodic syndrome (TRAPS). 99
Gene therapy for mucopolysaccharidoses: in vivo and ex vivo approaches 97
Efficacy of a combined intracerebral and systemic gene delivery approach for the treatment of a severe lysosomal storage disorder. 96
Un giorno alla volta, un'ora alla volta 93
The Amyloid Inhibitor CLR01 Relieves Autophagy and Ameliorates Neuropathology in a Severe Lysosomal Storage Disease 93
Lysosomal storage diseases as disorders of autophagy 85
Sulphatase activities are regulated by the interaction of sulphatase-modifying factor 1 with SUMF2 79
Inhibition of Lipofuscin Aggregation by Molecular Tweezers. 79
Functional correction of CNS lesions in an MPS-IIIA mouse model by intracerebral AAV-mediated delivery of sulfamidase and SUMF1 genes. 77
Sulfatase activities are regulated by the interaction of the sulfatase-modifying factor 1 with SUMF2 77
Signals from the lysosome: a control centre for cellular clearance and energy metabolism. 70
In vivo Gene Therapy to the Liver and Nervous System: Promises and Challenges 70
Binding of the 7SK snRNA turns the HEXIM1 protein into a P-TEFb (CDK9/cyclin T) inhibitor 69
Brain Disorders Due to Lysomal Dysfunction 65
SUMF1 enhances sulfatase activities in vivo in five sulfatase deficiencies. 64
Therapeutic strategies to treat CNS pathology in Mucopolysaccharidoses 62
Zinc-α2-glycoprotein hinders cell proliferation and reduces cdc2 expression 54
LET’Sanfilippo FIGHTers - Mucopolysaccharidosis 3 Workshop 48
Istologia Umana 42
Protein Aggregation and Dysfunction of Autophagy-Lysosomal Pathway: A Vicious Cycle in Lysosomal Storage Diseases 41
Progressive activation of the astrocyte A1 phenotype underlies microglia-astroglia crosstalk and contributes to neuroinflammation in neuronopathic MPS 33
Istologia 31
Commentary: Lysosomal enzymes engineered to cross the blood-brain barrier are reshaping the therapeutic landscape of neuronopathic mucopolysaccharidoses 17
Totale 6.715
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Categoria #
all - tutte 18.844
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 18.844
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/202122 0 0 0 0 0 0 0 0 0 1 6 15
2021/2022280 11 4 2 9 16 8 3 10 35 15 57 110
2022/2023395 55 55 8 18 47 35 5 34 49 64 21 4
2023/2024302 26 31 81 13 13 22 13 14 11 17 40 21
2024/20251.625 68 104 9 20 42 84 196 109 91 160 559 183
2025/20263.489 354 306 372 420 603 195 377 272 410 180 0 0
Totale 6.715