IRIS
LA PIETRA, VALERIA
 Distribuzione geografica
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Continente #
NA - Nord America 738
EU - Europa 416
AS - Asia 311
AF - Africa 30
Continente sconosciuto - Info sul continente non disponibili 1
SA - Sud America 1
Totale 1.497
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Nazione #
US - Stati Uniti d'America 718
IT - Italia 230
SG - Singapore 150
CN - Cina 127
NL - Olanda 58
IE - Irlanda 45
FI - Finlandia 38
CI - Costa d'Avorio 29
CA - Canada 20
DE - Germania 11
GB - Regno Unito 11
IN - India 8
VN - Vietnam 8
IR - Iran 6
RU - Federazione Russa 5
TR - Turchia 5
FR - Francia 4
HU - Ungheria 2
JP - Giappone 2
SE - Svezia 2
AE - Emirati Arabi Uniti 1
AT - Austria 1
BE - Belgio 1
CZ - Repubblica Ceca 1
EC - Ecuador 1
EE - Estonia 1
EG - Egitto 1
EU - Europa 1
HK - Hong Kong 1
IL - Israele 1
KH - Cambogia 1
KR - Corea 1
LT - Lituania 1
LV - Lettonia 1
MK - Macedonia 1
NO - Norvegia 1
PL - Polonia 1
RO - Romania 1
Totale 1.497
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Città #
Chandler 151
Singapore 126
Santa Clara 87
Amsterdam 57
Naples 54
Ashburn 47
Millbury 44
Napoli 41
Princeton 33
Beijing 32
Nanjing 31
Des Moines 22
Ottawa 20
Boston 15
Wilmington 10
Augusta 9
Dong Ket 8
Hebei 8
Lawrence 8
Milan 8
Nanchang 8
Santa Maria Capua Vetere 8
Shenyang 8
Rome 7
Seattle 7
San Mateo 6
Bologna 5
Dearborn 5
Helsinki 5
Tianjin 5
Changsha 4
Chicago 4
Filottrano 4
Jiaxing 4
Reggio Emilia 4
Caserta 3
Dublin 3
Hangzhou 3
Los Angeles 3
Munich 3
Orta di Atella 3
Pune 3
Ann Arbor 2
Ardabil 2
Arzano 2
Budapest 2
Custonaci 2
Edinburgh 2
Florence 2
Guangzhou 2
Houston 2
Jacksonville 2
Jinan 2
Kunming 2
Lappeenranta 2
Leawood 2
Mugnano di Napoli 2
Ningbo 2
Paulding 2
Quarto 2
San Biagio di Callalta 2
San Giuliano 2
Sandston 2
Taizhou 2
Tokyo 2
Torre del Greco 2
Washington 2
Woodbridge 2
Acerra 1
Altamura 1
Antwerp 1
Banstead 1
Binzhou 1
Brescia 1
Cagliari 1
Casoria 1
Castrop-rauxel 1
Ceppaloni 1
Chuncheon 1
Dallas 1
Darmstadt 1
Dezhou 1
Dubai 1
Falkenstein 1
Falls Church 1
Frankfurt am Main 1
Fremont 1
Greenwich 1
Guayaquil 1
Handan 1
Hong Kong 1
Ilford 1
Ischia 1
Islington 1
Istanbul 1
Jianning 1
London 1
Montesilvano Marina 1
Mountain View 1
New Kensington 1
Totale 1.000
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Nome #
Computer-Aided Identification and Lead Optimization of Dual Murine Double Minute 2 and 4 Binders: Structure-Activity Relationship Studies and Pharmacological Activity 74
Bax Activation Blocks Self-Renewal and Induces Apoptosis of Human Glioblastoma Stem Cells 60
Structure-based lead optimization and biological evaluation of BAX direct activators as novel potential anticancer agents 56
Exploring the N-Terminal Region of C-X-C Motif Chemokine 12 (CXCL12): Identification of Plasma-Stable Cyclic Peptides As Novel, Potent C-X-C Chemokine Receptor Type 4 (CXCR4) Antagonists 54
A more detailed picture of the interactions between virtual screening-derived hits and the DNA G-quadruplex: NMR, molecular modelling and ITC studies. 46
A more detailed picture of the interactions between Virtual Screening-derived Hits and the DNA G-Quadruplex: NMR, Molecular Modeling and ITC Studies 43
Benzothiopyranoindole- and pyridothiopyranoindole-based antiproliferative agents targeting topoisomerases 42
Discovery of Covalent Inhibitors of Glyceraldehyde-3-phosphate Dehydrogenase, A Target for the Treatment of Malaria 39
Long lasting inhibition of Mdm2-p53 interaction potentiates mesenchymal stem cell differentiation into osteoblasts 39
Enriching the arsenal of pharmacological tools against mical2 39
Novel peptidomimetics as BACE-1 inhibitors: synthesis, molecular modeling, and biological studies 38
Discovery of the First-in-Class GSK-3β/HDAC Dual Inhibitor as Disease-Modifying Agent to Combat Alzheimer's Disease 38
Interfering with the Tumor-Immune Interface: Making Way for Triazine-Based Small Molecules as Novel PD-L1 Inhibitors 38
State-of-the-art methodologies for the discovery and characterization of DNA G-Quadruplex binders 37
Human recombinant beta-secretase immobilized enzyme reactor for fast hits' selection and characterization from a virtual screening library 37
Apoptosis Therapy in Cancer: The First Single-molecule Co-activating p53 and the Translocator Protein in Glioblastoma 37
Challenging clinically unresponsive medullary thyroid cancer: Discovery and pharmacological activity of novel RET inhibitors 36
Non-nucleoside inhibitors of human adenosine kinase: synthesis, molecular modeling, and biological studies. 35
Identification of novel molecular scaffolds for the design of MMP-13 inhibitors: A first round of lead optimization. 35
Best Matching Protein Conformations and Docking Programs for a Virtual Screening Campaign Against SMO Receptor 35
Theoretical and experimental studies on the interaction of biphenyl ligands with human and murine PD-L1: Up-to-date clues for drug design 34
Arylsulfonamide inhibitors of aggrecanases as potential therapeutic agents for osteoarthritis: Synthesis and biological evaluation 33
A reverse translational approach reveals the protective roles of Mangifera indica in inflammatory bowel disease 32
N-O-ISOPROPYL SULFONAMIDO-BASED HYDROXAMATES: KINETIC CHARACTERISATION OF A SERIES OF MMP-12/MMP-13 DUAL TARGET INHIBITORS. 32
Progresses in the pursuit of aldose reductase inhibitors: the structure-based lead optimization step. 32
Receptor-bound conformation of cilengitide better represented by its solution-state structure than the solid-state structure 32
Development of novel dipeptide-like rhodesain inhibitors containing the 3-bromoisoxazoline warhead in a constrained conformation 32
Development and Nanoparticle-Mediated Delivery of Novel MDM2/MDM4 Heterodimer Peptide Inhibitors to Enhance 5-Fluorouracil Nucleolar Stress in Colorectal Cancer Cells 31
Identification of Glycogen Synthase Kinase-3 Inhibitors with a Selective Sting for Glycogen Synthase Kinase-3α 30
Identification of a Novel p53 Modulator Endowed with Antitumoural and Antibacterial Activity through a Scaffold Repurposing Approach 29
Simultaneous Targeting of RGD-Integrins and Dual Murine Double Minute Proteins in Glioblastoma Multiforme 29
Design, synthesis and biological evaluation of novel TRβ selective agonists sustained by ADME-toxicity analysis 29
p53 Functional Inhibitors Behaving Like Pifithrin-? Counteract the Alzheimer Peptide Non-?-amyloid Component Effects in Human SH-SY5Y Cells 28
Structure-Based Optimization of Tyrosine Kinase InhibitorCLM3. Design, Synthesis, Functional Evaluation, and Molecular Modeling Studies. 27
Lead Optimization of 2-Phenylindolylglyoxylyldipeptide Murine Double Minute (MDM)2/Translocator Protein (TSPO) Dual Inhibitors for the Treatment of Gliomas 27
Design, Synthesis, and Biological Evaluation of 1-Phenylpyrazolo[3,4-e]pyrrolo[3,4-g]indolizine-4,6(1H,5H)-diones as New Glycogen Synthase Kinase-3 beta Inhibitors 26
A novel cell-permeable, selective, and noncompetitive inhibitor of KAT3 histone acetyltransferases from a combined molecular pruning/classical isosterism approach 26
Site-directed Mutagenesis of Key Residues Unveiled a Novel Allosteric Site on Human Adenosine Kinase for Pyrrolobenzoxa(thia)zepinone Non-Nucleoside Inhibitors 26
A stereoselective approach to peptidomimetic BACE1 inhibitors 24
Protein Flexibility in Virtual Screening: The BACE-1 Case Study 24
CXCR4 antagonism sensitizes cancer cells to novel indole-based MDM2/4 inhibitors in glioblastoma multiforme 23
HuR-targeted agents: An insight into medicinal chemistry, biophysical, computational studies and pharmacological effects on cancer models 22
N-O-Isopropyl Sulfonamido-Based Hydroxamates: Design, Synthesis and Biological Evaluation of Selective Matrix Metalloproteinase-13 Inhibitors as Potential Therapeutic Agents for Osteoarthritis 21
HuR modulation counteracts lipopolysaccharide response in murine macrophages 20
Potent Arylsulfonamide Inhibitors of Tumor Necrosis Factor-alfa Converting Enzyme Able to Reduce Activated Leukocyte Cell Adhesion Molecule Shedding in Cancer Cell Models 20
Synthesis and biological evaluation in U87MG glioma cells of (ethynylthiophene)sulfonamido-based hydroxamates as matrix metalloproteinase inhibitors. 20
A combined approach of structure‐based virtual screening and NMR to interrupt the PD‐1/PD‐L1 axis: Biphenyl‐benzimidazole containing compounds as novel PD‐L1 inhibitors 18
Selective Arylsulfonamide Inhibitors of ADAM-17: Hit Optimization and Activity in Ovarian Cancer Cell Models 18
Combination of 5-FU and MDM2/4 peptide inhibitors as a promising strategy to enhance 5-FU induced nucleolar stress. 10
Editorial: Promising tools in targeted cancer therapy 6
Enhanced 5-FU-mediated activation of p53-dependent nucleolar stress by MDM2/4 peptide inhibitors in colon cancer cells 6
MDM2/4 inhibitors as novel therapeutic strategy to enhance 5-FU induced nucleolar stress and apoptosis in colon cancer cells 5
Development and Nanoparticle-Mediated Delivery of Novel MDM2/MDM4 Heterodimer Peptide Inhibitors to Enhance 5-Fluorouracil Nucleolar Stress in Colorectal Cancer Cells 3
Novel, soluble 3-heteroaryl-substituted tanshinone mimics attenuate the inflammatory response in murine macrophages 2
Protective effects of olive oil antioxidant phenols on mercury-induced phosphatidylserine externalization in erythrocyte membrane: Insights into scramblase and flippase activity 1
Totale 1.636
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Categoria #
all - tutte 7.804
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 7.804
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/202053 0 0 0 0 0 0 4 1 0 14 26 8
2020/2021106 5 1 4 1 2 32 2 10 13 1 25 10
2021/2022226 3 2 4 1 4 1 0 12 51 36 22 90
2022/2023360 41 15 13 34 40 44 0 28 55 58 27 5
2023/2024258 24 26 34 23 18 23 11 34 1 3 43 18
2024/2025366 66 93 4 38 27 136 2 0 0 0 0 0
Totale 1.636