IRIS
LA PIETRA, VALERIA
 Distribuzione geografica
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Continente #
AS - Asia 2.132
NA - Nord America 1.923
EU - Europa 1.527
SA - Sud America 259
Continente sconosciuto - Info sul continente non disponibili 141
AF - Africa 68
OC - Oceania 3
Totale 6.053
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Nazione #
US - Stati Uniti d'America 1.832
SG - Singapore 895
RU - Federazione Russa 685
CN - Cina 446
IT - Italia 385
VN - Vietnam 372
BR - Brasile 204
HK - Hong Kong 147
DE - Germania 83
NL - Olanda 74
FR - Francia 70
FI - Finlandia 66
CA - Canada 56
IN - India 49
IE - Irlanda 48
JP - Giappone 42
BD - Bangladesh 37
GB - Regno Unito 36
CI - Costa d'Avorio 30
AR - Argentina 26
KR - Corea 22
IQ - Iraq 21
MX - Messico 19
PL - Polonia 16
TR - Turchia 14
PH - Filippine 13
EC - Ecuador 10
ES - Italia 10
TH - Thailandia 10
MA - Marocco 9
SE - Svezia 9
ID - Indonesia 8
PK - Pakistan 8
TW - Taiwan 8
ZA - Sudafrica 8
AT - Austria 7
UA - Ucraina 7
IR - Iran 6
JM - Giamaica 6
BE - Belgio 5
VE - Venezuela 5
LB - Libano 4
LT - Lituania 4
PY - Paraguay 4
UZ - Uzbekistan 4
AE - Emirati Arabi Uniti 3
AZ - Azerbaigian 3
CL - Cile 3
CR - Costa Rica 3
ET - Etiopia 3
NP - Nepal 3
PE - Perù 3
RO - Romania 3
TN - Tunisia 3
AL - Albania 2
AU - Australia 2
CG - Congo 2
CO - Colombia 2
DZ - Algeria 2
EE - Estonia 2
EG - Egitto 2
GF - Guiana Francese 2
HN - Honduras 2
HU - Ungheria 2
IL - Israele 2
JO - Giordania 2
KZ - Kazakistan 2
LU - Lussemburgo 2
NE - Niger 2
PA - Panama 2
SY - Repubblica araba siriana 2
BN - Brunei Darussalam 1
CZ - Repubblica Ceca 1
DO - Repubblica Dominicana 1
EU - Europa 1
GA - Gabon 1
GE - Georgia 1
GH - Ghana 1
GN - Guinea 1
GR - Grecia 1
HR - Croazia 1
IS - Islanda 1
KH - Cambogia 1
KW - Kuwait 1
LV - Lettonia 1
MD - Moldavia 1
MK - Macedonia 1
MN - Mongolia 1
MY - Malesia 1
NG - Nigeria 1
NO - Norvegia 1
NZ - Nuova Zelanda 1
PR - Porto Rico 1
PS - Palestinian Territory 1
PT - Portogallo 1
QA - Qatar 1
RS - Serbia 1
SA - Arabia Saudita 1
SD - Sudan 1
SK - Slovacchia (Repubblica Slovacca) 1
Totale 5.910
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Città #
Singapore 424
San Jose 372
Moscow 163
Ashburn 155
Chandler 151
Beijing 150
Hong Kong 139
Naples 102
Santa Clara 102
Ho Chi Minh City 101
Hanoi 99
Dallas 92
Hefei 80
Amsterdam 64
Council Bluffs 50
The Dalles 49
Lauterbourg 47
Los Angeles 46
Millbury 44
Napoli 41
Tokyo 34
Princeton 33
Nanjing 31
Munich 28
Des Moines 24
Rome 24
Boston 20
Buffalo 20
Chicago 20
Ottawa 20
Redondo Beach 20
Phoenix 19
Haiphong 18
New York 18
Düsseldorf 16
São Paulo 16
Turku 16
Da Nang 15
Orem 15
Milan 14
Seattle 14
Seoul 14
Frankfurt am Main 13
Warsaw 13
Mexico City 11
Brooklyn 10
Helsinki 10
Wilmington 10
Augusta 9
Falkenstein 9
Kochi 9
Lappeenranta 9
Montreal 9
Atlanta 8
Bagnoli Irpino 8
Bologna 8
Chennai 8
Dong Ket 8
Hebei 8
Lawrence 8
Nanchang 8
Santa Maria Capua Vetere 8
Shenyang 8
Denver 7
Houston 7
Nuremberg 7
Rio de Janeiro 7
San Mateo 7
Secaucus 7
Stockholm 7
Toronto 7
Ankara 6
Baghdad 6
Changsha 6
Kingston 6
Quận Bình Thạnh 6
Tianjin 6
Belo Horizonte 5
Bắc Giang 5
Casablanca 5
Dearborn 5
Dublin 5
Hải Dương 5
Nha Trang 5
Pisa 5
Tân Tiến 5
Can Tho 4
Charlotte 4
Filottrano 4
Florence 4
Guangzhou 4
Ha Long 4
Jacksonville 4
Jiaxing 4
Johannesburg 4
Las Vegas 4
London 4
Madrid 4
Reggio Emilia 4
San Francisco 4
Totale 3.305
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Nome #
A reverse translational approach reveals the protective roles of Mangifera indica in inflammatory bowel disease 210
Computer-Aided Identification and Lead Optimization of Dual Murine Double Minute 2 and 4 Binders: Structure-Activity Relationship Studies and Pharmacological Activity 201
Interfering with the Tumor-Immune Interface: Making Way for Triazine-Based Small Molecules as Novel PD-L1 Inhibitors 177
Development and Nanoparticle-Mediated Delivery of Novel MDM2/MDM4 Heterodimer Peptide Inhibitors to Enhance 5-Fluorouracil Nucleolar Stress in Colorectal Cancer Cells 173
Exploring the N-Terminal Region of C-X-C Motif Chemokine 12 (CXCL12): Identification of Plasma-Stable Cyclic Peptides As Novel, Potent C-X-C Chemokine Receptor Type 4 (CXCR4) Antagonists 168
A more detailed picture of the interactions between Virtual Screening-derived Hits and the DNA G-Quadruplex: NMR, Molecular Modeling and ITC Studies 148
State-of-the-art methodologies for the discovery and characterization of DNA G-Quadruplex binders 147
Theoretical and experimental studies on the interaction of biphenyl ligands with human and murine PD-L1: Up-to-date clues for drug design 146
Structure-based lead optimization and biological evaluation of BAX direct activators as novel potential anticancer agents 144
Enriching the arsenal of pharmacological tools against mical2 142
A combined approach of structure‐based virtual screening and NMR to interrupt the PD‐1/PD‐L1 axis: Biphenyl‐benzimidazole containing compounds as novel PD‐L1 inhibitors 139
Simultaneous Targeting of RGD-Integrins and Dual Murine Double Minute Proteins in Glioblastoma Multiforme 136
Progresses in the pursuit of aldose reductase inhibitors: the structure-based lead optimization step. 133
Design, synthesis and biological evaluation of novel TRβ selective agonists sustained by ADME-toxicity analysis 131
Identification of a Novel p53 Modulator Endowed with Antitumoural and Antibacterial Activity through a Scaffold Repurposing Approach 130
Novel peptidomimetics as BACE-1 inhibitors: synthesis, molecular modeling, and biological studies 130
Protective effects of olive oil antioxidant phenols on mercury-induced phosphatidylserine externalization in erythrocyte membrane: Insights into scramblase and flippase activity 129
Enhanced 5-FU-mediated activation of p53-dependent nucleolar stress by MDM2/4 peptide inhibitors in colon cancer cells 128
Discovery of the First-in-Class GSK-3β/HDAC Dual Inhibitor as Disease-Modifying Agent to Combat Alzheimer's Disease 128
A more detailed picture of the interactions between virtual screening-derived hits and the DNA G-quadruplex: NMR, molecular modelling and ITC studies. 127
Combination of 5-FU and MDM2/4 peptide inhibitors as a promising strategy to enhance 5-FU induced nucleolar stress. 123
MDM2/4 inhibitors as novel therapeutic strategy to enhance 5-FU induced nucleolar stress and apoptosis in colon cancer cells 122
N-O-ISOPROPYL SULFONAMIDO-BASED HYDROXAMATES: KINETIC CHARACTERISATION OF A SERIES OF MMP-12/MMP-13 DUAL TARGET INHIBITORS. 120
A stereoselective approach to peptidomimetic BACE1 inhibitors 120
CXCR4 antagonism sensitizes cancer cells to novel indole-based MDM2/4 inhibitors in glioblastoma multiforme 118
Long lasting inhibition of Mdm2-p53 interaction potentiates mesenchymal stem cell differentiation into osteoblasts 117
Best Matching Protein Conformations and Docking Programs for a Virtual Screening Campaign Against SMO Receptor 114
Bax Activation Blocks Self-Renewal and Induces Apoptosis of Human Glioblastoma Stem Cells 113
Design, Synthesis, and Biological Evaluation of 1-Phenylpyrazolo[3,4-e]pyrrolo[3,4-g]indolizine-4,6(1H,5H)-diones as New Glycogen Synthase Kinase-3 beta Inhibitors 112
Protein Flexibility in Virtual Screening: The BACE-1 Case Study 111
Identification of novel molecular scaffolds for the design of MMP-13 inhibitors: A first round of lead optimization. 107
Challenging clinically unresponsive medullary thyroid cancer: Discovery and pharmacological activity of novel RET inhibitors 106
Human recombinant beta-secretase immobilized enzyme reactor for fast hits' selection and characterization from a virtual screening library 105
Site-directed Mutagenesis of Key Residues Unveiled a Novel Allosteric Site on Human Adenosine Kinase for Pyrrolobenzoxa(thia)zepinone Non-Nucleoside Inhibitors 102
Selective Arylsulfonamide Inhibitors of ADAM-17: Hit Optimization and Activity in Ovarian Cancer Cell Models 97
Structure-Based Optimization of Tyrosine Kinase InhibitorCLM3. Design, Synthesis, Functional Evaluation, and Molecular Modeling Studies. 97
Discovery of Covalent Inhibitors of Glyceraldehyde-3-phosphate Dehydrogenase, A Target for the Treatment of Malaria 97
Lead Optimization of 2-Phenylindolylglyoxylyldipeptide Murine Double Minute (MDM)2/Translocator Protein (TSPO) Dual Inhibitors for the Treatment of Gliomas 92
Benzothiopyranoindole- and pyridothiopyranoindole-based antiproliferative agents targeting topoisomerases 89
Receptor-bound conformation of cilengitide better represented by its solution-state structure than the solid-state structure 88
Potent Arylsulfonamide Inhibitors of Tumor Necrosis Factor-alfa Converting Enzyme Able to Reduce Activated Leukocyte Cell Adhesion Molecule Shedding in Cancer Cell Models 84
Non-nucleoside inhibitors of human adenosine kinase: synthesis, molecular modeling, and biological studies. 73
Apoptosis Therapy in Cancer: The First Single-molecule Co-activating p53 and the Translocator Protein in Glioblastoma 73
HuR modulation counteracts lipopolysaccharide response in murine macrophages 72
Development of novel dipeptide-like rhodesain inhibitors containing the 3-bromoisoxazoline warhead in a constrained conformation 72
Identification of Glycogen Synthase Kinase-3 Inhibitors with a Selective Sting for Glycogen Synthase Kinase-3α 71
HuR-targeted agents: An insight into medicinal chemistry, biophysical, computational studies and pharmacological effects on cancer models 70
A novel cell-permeable, selective, and noncompetitive inhibitor of KAT3 histone acetyltransferases from a combined molecular pruning/classical isosterism approach 66
Editorial: Promising tools in targeted cancer therapy 64
Arylsulfonamide inhibitors of aggrecanases as potential therapeutic agents for osteoarthritis: Synthesis and biological evaluation 63
p53 Functional Inhibitors Behaving Like Pifithrin-? Counteract the Alzheimer Peptide Non-?-amyloid Component Effects in Human SH-SY5Y Cells 60
Novel, soluble 3-heteroaryl-substituted tanshinone mimics attenuate the inflammatory response in murine macrophages 59
Synthesis and biological evaluation in U87MG glioma cells of (ethynylthiophene)sulfonamido-based hydroxamates as matrix metalloproteinase inhibitors. 58
N-O-Isopropyl Sulfonamido-Based Hydroxamates: Design, Synthesis and Biological Evaluation of Selective Matrix Metalloproteinase-13 Inhibitors as Potential Therapeutic Agents for Osteoarthritis 51
Totale 6.053
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Categoria #
all - tutte 20.057
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 20.057
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022221 0 0 4 1 4 1 0 12 51 36 22 90
2022/2023360 41 15 13 34 40 44 0 28 55 58 27 5
2023/2024258 24 26 34 23 18 23 11 34 1 3 43 18
2024/20251.583 66 93 4 38 27 133 172 136 91 153 542 128
2025/20262.982 311 235 378 254 498 106 314 202 338 187 96 63
2026/2027218 44 102 72 0 0 0 0 0 0 0 0 0
Totale 6.053