IRIS
LA PIETRA, VALERIA
 Distribuzione geografica
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Continente #
AS - Asia 2.125
NA - Nord America 1.762
EU - Europa 1.513
SA - Sud America 258
AF - Africa 67
OC - Oceania 3
Continente sconosciuto - Info sul continente non disponibili 1
Totale 5.729
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Nazione #
US - Stati Uniti d'America 1.684
SG - Singapore 895
RU - Federazione Russa 685
CN - Cina 443
VN - Vietnam 372
IT - Italia 371
BR - Brasile 203
HK - Hong Kong 146
DE - Germania 83
NL - Olanda 74
FR - Francia 70
FI - Finlandia 66
IN - India 49
IE - Irlanda 48
CA - Canada 47
JP - Giappone 42
GB - Regno Unito 36
BD - Bangladesh 35
CI - Costa d'Avorio 30
AR - Argentina 26
KR - Corea 22
IQ - Iraq 21
MX - Messico 18
PL - Polonia 16
TR - Turchia 14
PH - Filippine 13
EC - Ecuador 10
ES - Italia 10
TH - Thailandia 10
MA - Marocco 9
SE - Svezia 9
ID - Indonesia 8
PK - Pakistan 8
TW - Taiwan 8
ZA - Sudafrica 8
AT - Austria 7
UA - Ucraina 7
IR - Iran 6
BE - Belgio 5
VE - Venezuela 5
JM - Giamaica 4
LB - Libano 4
LT - Lituania 4
PY - Paraguay 4
UZ - Uzbekistan 4
AE - Emirati Arabi Uniti 3
AZ - Azerbaigian 3
CL - Cile 3
ET - Etiopia 3
NP - Nepal 3
PE - Perù 3
RO - Romania 3
TN - Tunisia 3
AL - Albania 2
AU - Australia 2
CO - Colombia 2
CR - Costa Rica 2
DZ - Algeria 2
EE - Estonia 2
EG - Egitto 2
GF - Guiana Francese 2
HN - Honduras 2
HU - Ungheria 2
IL - Israele 2
JO - Giordania 2
KZ - Kazakistan 2
LU - Lussemburgo 2
NE - Niger 2
PA - Panama 2
SY - Repubblica araba siriana 2
BN - Brunei Darussalam 1
CG - Congo 1
CZ - Repubblica Ceca 1
DO - Repubblica Dominicana 1
EU - Europa 1
GA - Gabon 1
GE - Georgia 1
GH - Ghana 1
GN - Guinea 1
GR - Grecia 1
HR - Croazia 1
IS - Islanda 1
KH - Cambogia 1
KW - Kuwait 1
LV - Lettonia 1
MD - Moldavia 1
MK - Macedonia 1
MN - Mongolia 1
MY - Malesia 1
NG - Nigeria 1
NO - Norvegia 1
NZ - Nuova Zelanda 1
PR - Porto Rico 1
PS - Palestinian Territory 1
PT - Portogallo 1
RS - Serbia 1
SA - Arabia Saudita 1
SD - Sudan 1
SK - Slovacchia (Repubblica Slovacca) 1
TT - Trinidad e Tobago 1
Totale 5.727
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Città #
Singapore 424
San Jose 325
Moscow 163
Chandler 151
Beijing 148
Ashburn 144
Hong Kong 139
Ho Chi Minh City 101
Naples 100
Hanoi 99
Santa Clara 97
Dallas 92
Hefei 80
Amsterdam 64
The Dalles 49
Lauterbourg 47
Los Angeles 46
Millbury 44
Napoli 41
Tokyo 34
Princeton 33
Nanjing 31
Munich 28
Des Moines 24
Rome 24
Buffalo 20
Ottawa 20
Redondo Beach 20
Boston 19
Chicago 18
Haiphong 18
Düsseldorf 16
New York 16
São Paulo 16
Turku 16
Da Nang 15
Orem 15
Seoul 14
Frankfurt am Main 13
Milan 13
Seattle 13
Warsaw 13
Council Bluffs 11
Mexico City 11
Brooklyn 10
Helsinki 10
Wilmington 10
Augusta 9
Falkenstein 9
Kochi 9
Lappeenranta 9
Bagnoli Irpino 8
Bologna 8
Chennai 8
Dong Ket 8
Hebei 8
Lawrence 8
Nanchang 8
Santa Maria Capua Vetere 8
Shenyang 8
Atlanta 7
Denver 7
Houston 7
Nuremberg 7
San Mateo 7
Secaucus 7
Stockholm 7
Toronto 7
Ankara 6
Baghdad 6
Changsha 6
Montreal 6
Quận Bình Thạnh 6
Rio de Janeiro 6
Tianjin 6
Belo Horizonte 5
Bắc Giang 5
Casablanca 5
Dearborn 5
Dublin 5
Hải Dương 5
Nha Trang 5
Pisa 5
Tân Tiến 5
Can Tho 4
Charlotte 4
Filottrano 4
Florence 4
Guangzhou 4
Ha Long 4
Jacksonville 4
Jiaxing 4
Johannesburg 4
Kingston 4
London 4
Madrid 4
Reggio Emilia 4
San Francisco 4
Vienna 4
Woodbridge 4
Totale 3.170
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Nome #
A reverse translational approach reveals the protective roles of Mangifera indica in inflammatory bowel disease 208
Computer-Aided Identification and Lead Optimization of Dual Murine Double Minute 2 and 4 Binders: Structure-Activity Relationship Studies and Pharmacological Activity 197
Interfering with the Tumor-Immune Interface: Making Way for Triazine-Based Small Molecules as Novel PD-L1 Inhibitors 173
Development and Nanoparticle-Mediated Delivery of Novel MDM2/MDM4 Heterodimer Peptide Inhibitors to Enhance 5-Fluorouracil Nucleolar Stress in Colorectal Cancer Cells 167
Exploring the N-Terminal Region of C-X-C Motif Chemokine 12 (CXCL12): Identification of Plasma-Stable Cyclic Peptides As Novel, Potent C-X-C Chemokine Receptor Type 4 (CXCR4) Antagonists 162
A more detailed picture of the interactions between Virtual Screening-derived Hits and the DNA G-Quadruplex: NMR, Molecular Modeling and ITC Studies 145
State-of-the-art methodologies for the discovery and characterization of DNA G-Quadruplex binders 142
Theoretical and experimental studies on the interaction of biphenyl ligands with human and murine PD-L1: Up-to-date clues for drug design 141
Structure-based lead optimization and biological evaluation of BAX direct activators as novel potential anticancer agents 138
Enriching the arsenal of pharmacological tools against mical2 137
A combined approach of structure‐based virtual screening and NMR to interrupt the PD‐1/PD‐L1 axis: Biphenyl‐benzimidazole containing compounds as novel PD‐L1 inhibitors 135
Simultaneous Targeting of RGD-Integrins and Dual Murine Double Minute Proteins in Glioblastoma Multiforme 132
Progresses in the pursuit of aldose reductase inhibitors: the structure-based lead optimization step. 131
Protective effects of olive oil antioxidant phenols on mercury-induced phosphatidylserine externalization in erythrocyte membrane: Insights into scramblase and flippase activity 126
Novel peptidomimetics as BACE-1 inhibitors: synthesis, molecular modeling, and biological studies 126
Identification of a Novel p53 Modulator Endowed with Antitumoural and Antibacterial Activity through a Scaffold Repurposing Approach 125
Enhanced 5-FU-mediated activation of p53-dependent nucleolar stress by MDM2/4 peptide inhibitors in colon cancer cells 123
A more detailed picture of the interactions between virtual screening-derived hits and the DNA G-quadruplex: NMR, molecular modelling and ITC studies. 122
Combination of 5-FU and MDM2/4 peptide inhibitors as a promising strategy to enhance 5-FU induced nucleolar stress. 121
Discovery of the First-in-Class GSK-3β/HDAC Dual Inhibitor as Disease-Modifying Agent to Combat Alzheimer's Disease 120
A stereoselective approach to peptidomimetic BACE1 inhibitors 119
Design, synthesis and biological evaluation of novel TRβ selective agonists sustained by ADME-toxicity analysis 119
MDM2/4 inhibitors as novel therapeutic strategy to enhance 5-FU induced nucleolar stress and apoptosis in colon cancer cells 118
N-O-ISOPROPYL SULFONAMIDO-BASED HYDROXAMATES: KINETIC CHARACTERISATION OF A SERIES OF MMP-12/MMP-13 DUAL TARGET INHIBITORS. 118
Long lasting inhibition of Mdm2-p53 interaction potentiates mesenchymal stem cell differentiation into osteoblasts 114
CXCR4 antagonism sensitizes cancer cells to novel indole-based MDM2/4 inhibitors in glioblastoma multiforme 112
Bax Activation Blocks Self-Renewal and Induces Apoptosis of Human Glioblastoma Stem Cells 109
Best Matching Protein Conformations and Docking Programs for a Virtual Screening Campaign Against SMO Receptor 109
Design, Synthesis, and Biological Evaluation of 1-Phenylpyrazolo[3,4-e]pyrrolo[3,4-g]indolizine-4,6(1H,5H)-diones as New Glycogen Synthase Kinase-3 beta Inhibitors 108
Protein Flexibility in Virtual Screening: The BACE-1 Case Study 107
Identification of novel molecular scaffolds for the design of MMP-13 inhibitors: A first round of lead optimization. 105
Human recombinant beta-secretase immobilized enzyme reactor for fast hits' selection and characterization from a virtual screening library 104
Challenging clinically unresponsive medullary thyroid cancer: Discovery and pharmacological activity of novel RET inhibitors 102
Site-directed Mutagenesis of Key Residues Unveiled a Novel Allosteric Site on Human Adenosine Kinase for Pyrrolobenzoxa(thia)zepinone Non-Nucleoside Inhibitors 100
Discovery of Covalent Inhibitors of Glyceraldehyde-3-phosphate Dehydrogenase, A Target for the Treatment of Malaria 96
Selective Arylsulfonamide Inhibitors of ADAM-17: Hit Optimization and Activity in Ovarian Cancer Cell Models 94
Structure-Based Optimization of Tyrosine Kinase InhibitorCLM3. Design, Synthesis, Functional Evaluation, and Molecular Modeling Studies. 93
Lead Optimization of 2-Phenylindolylglyoxylyldipeptide Murine Double Minute (MDM)2/Translocator Protein (TSPO) Dual Inhibitors for the Treatment of Gliomas 90
Receptor-bound conformation of cilengitide better represented by its solution-state structure than the solid-state structure 87
Benzothiopyranoindole- and pyridothiopyranoindole-based antiproliferative agents targeting topoisomerases 85
Potent Arylsulfonamide Inhibitors of Tumor Necrosis Factor-alfa Converting Enzyme Able to Reduce Activated Leukocyte Cell Adhesion Molecule Shedding in Cancer Cell Models 81
Apoptosis Therapy in Cancer: The First Single-molecule Co-activating p53 and the Translocator Protein in Glioblastoma 72
Non-nucleoside inhibitors of human adenosine kinase: synthesis, molecular modeling, and biological studies. 71
Development of novel dipeptide-like rhodesain inhibitors containing the 3-bromoisoxazoline warhead in a constrained conformation 71
Identification of Glycogen Synthase Kinase-3 Inhibitors with a Selective Sting for Glycogen Synthase Kinase-3α 70
HuR modulation counteracts lipopolysaccharide response in murine macrophages 69
HuR-targeted agents: An insight into medicinal chemistry, biophysical, computational studies and pharmacological effects on cancer models 66
A novel cell-permeable, selective, and noncompetitive inhibitor of KAT3 histone acetyltransferases from a combined molecular pruning/classical isosterism approach 64
Arylsulfonamide inhibitors of aggrecanases as potential therapeutic agents for osteoarthritis: Synthesis and biological evaluation 62
Editorial: Promising tools in targeted cancer therapy 61
p53 Functional Inhibitors Behaving Like Pifithrin-? Counteract the Alzheimer Peptide Non-?-amyloid Component Effects in Human SH-SY5Y Cells 59
Novel, soluble 3-heteroaryl-substituted tanshinone mimics attenuate the inflammatory response in murine macrophages 57
Synthesis and biological evaluation in U87MG glioma cells of (ethynylthiophene)sulfonamido-based hydroxamates as matrix metalloproteinase inhibitors. 57
N-O-Isopropyl Sulfonamido-Based Hydroxamates: Design, Synthesis and Biological Evaluation of Selective Matrix Metalloproteinase-13 Inhibitors as Potential Therapeutic Agents for Osteoarthritis 49
Totale 5.869
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Categoria #
all - tutte 18.701
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 18.701
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022226 3 2 4 1 4 1 0 12 51 36 22 90
2022/2023360 41 15 13 34 40 44 0 28 55 58 27 5
2023/2024258 24 26 34 23 18 23 11 34 1 3 43 18
2024/20251.583 66 93 4 38 27 133 172 136 91 153 542 128
2025/20262.982 311 235 378 254 498 106 314 202 338 187 96 63
2026/202734 34 0 0 0 0 0 0 0 0 0 0 0
Totale 5.869