IRIS
MARINELLI, LUCIANA
 Distribuzione geografica
Salva come PNG Salva come JPEG
Continente #
AS - Asia 5.177
EU - Europa 4.667
NA - Nord America 4.230
SA - Sud America 770
AF - Africa 166
Continente sconosciuto - Info sul continente non disponibili 6
OC - Oceania 3
Totale 15.019
Salva come PNG Salva come JPEG
Nazione #
US - Stati Uniti d'America 4.052
SG - Singapore 2.862
RU - Federazione Russa 2.182
CN - Cina 1.176
IT - Italia 990
BR - Brasile 631
HK - Hong Kong 436
VN - Vietnam 362
DE - Germania 339
NL - Olanda 241
FI - Finlandia 196
IE - Irlanda 164
GB - Regno Unito 124
CA - Canada 115
UA - Ucraina 100
IN - India 80
SE - Svezia 77
CI - Costa d'Avorio 70
FR - Francia 70
AR - Argentina 68
MX - Messico 40
ZA - Sudafrica 38
BD - Bangladesh 37
TR - Turchia 35
JP - Giappone 32
KR - Corea 32
PL - Polonia 32
IQ - Iraq 29
ES - Italia 27
AT - Austria 26
BE - Belgio 24
EC - Ecuador 21
ID - Indonesia 20
VE - Venezuela 15
LT - Lituania 12
MA - Marocco 11
CH - Svizzera 10
PY - Paraguay 10
CO - Colombia 9
IR - Iran 9
BG - Bulgaria 7
CL - Cile 7
ET - Etiopia 7
AZ - Azerbaigian 6
IL - Israele 6
MY - Malesia 6
UZ - Uzbekistan 6
AE - Emirati Arabi Uniti 5
CZ - Repubblica Ceca 5
EE - Estonia 5
EG - Egitto 5
HR - Croazia 5
JO - Giordania 5
PK - Pakistan 5
DZ - Algeria 4
EU - Europa 4
PA - Panama 4
PE - Perù 4
PT - Portogallo 4
TN - Tunisia 4
TT - Trinidad e Tobago 4
DO - Repubblica Dominicana 3
GR - Grecia 3
KE - Kenya 3
LU - Lussemburgo 3
NE - Niger 3
NG - Nigeria 3
NI - Nicaragua 3
NP - Nepal 3
PS - Palestinian Territory 3
RS - Serbia 3
SN - Senegal 3
UY - Uruguay 3
AF - Afghanistan, Repubblica islamica di 2
AL - Albania 2
BN - Brunei Darussalam 2
CG - Congo 2
GE - Georgia 2
GF - Guiana Francese 2
HU - Ungheria 2
IS - Islanda 2
JM - Giamaica 2
LB - Libano 2
MD - Moldavia 2
ME - Montenegro 2
MK - Macedonia 2
NO - Norvegia 2
PH - Filippine 2
RO - Romania 2
SA - Arabia Saudita 2
TH - Thailandia 2
TW - Taiwan 2
ZM - Zambia 2
ZW - Zimbabwe 2
AO - Angola 1
BH - Bahrain 1
BJ - Benin 1
BZ - Belize 1
CW - ???statistics.table.value.countryCode.CW??? 1
CY - Cipro 1
Totale 14.996
Salva come PNG Salva come JPEG
Città #
Singapore 1.309
Moscow 546
Chandler 524
Hong Kong 434
Beijing 370
Ashburn 323
Naples 233
Dallas 221
Amsterdam 220
Santa Clara 211
Hefei 174
Millbury 173
Napoli 149
Princeton 142
Nanjing 141
Ho Chi Minh City 118
Los Angeles 116
Jacksonville 103
Boston 97
Ottawa 75
Munich 73
Buffalo 70
Hanoi 70
Woodbridge 67
Des Moines 62
Redondo Beach 58
Wilmington 57
São Paulo 56
San Jose 52
New York 49
Chicago 42
Houston 39
The Dalles 38
Rome 37
Seattle 37
Milan 36
Dong Ket 34
Nanchang 34
Helsinki 32
Tokyo 31
Seoul 28
Warsaw 27
Düsseldorf 26
Hebei 26
Shenyang 26
Turku 26
Brooklyn 25
Tianjin 25
Jiaxing 24
Frankfurt am Main 23
Brussels 22
Falkenstein 22
Mexico City 22
Nürnberg 19
Poplar 19
Dearborn 18
Lawrence 18
Changsha 17
Denver 17
Ann Arbor 16
Augusta 16
Johannesburg 16
Norwalk 16
Baghdad 15
Nuremberg 15
Rio de Janeiro 15
Atlanta 14
Boardman 14
Da Nang 14
Dublin 14
Stockholm 14
Toronto 14
Ankara 13
Belo Horizonte 13
Guangzhou 13
Kronberg 13
Leawood 13
London 13
Orem 13
Shanghai 13
Florence 12
Porto Alegre 12
San Francisco 12
Campinas 11
Kochi 11
Lappeenranta 11
Ninh Bình 11
Vienna 11
Chennai 10
Kunming 10
Lauterbourg 10
Pune 10
Redwood City 10
Secaucus 10
Bologna 9
Curitiba 9
Falls Church 9
Manchester 9
Montreal 9
San Mateo 9
Totale 7.585
Salva come PNG Salva come JPEG
Nome #
Annurca (Malus pumila Miller cv. Annurca) apple as a functional food for the contribution to a healthy balance of plasma cholesterol levels: results of a randomized clinical trial 206
Functional Selectivity Revealed by N-Methylation Scanning of Human Urotensin II and Related Peptides 204
Pharmacophoric Modifications Lead to Superpotent avb3 Integrin Ligands with Suppressed a5b1 Activity 193
A Healthy Balance of Plasma Cholesterol by a Novel Annurca Apple-Based Nutraceutical Formulation: Results of a Randomized Trial 181
Screening Platform toward New Anti-HIV Aptamers Set on Molecular Docking and Fluorescence Quenching Techniques 163
A reverse translational approach reveals the protective roles of Mangifera indica in inflammatory bowel disease 158
Computer-Aided Identification and Lead Optimization of Dual Murine Double Minute 2 and 4 Binders: Structure-Activity Relationship Studies and Pharmacological Activity 155
Structural and conformational requisites in DNA quadruplex groove binding: Another piece to the puzzle 152
Endogenous vs Exogenous Allosteric Modulators in GPCRs: A dispute for shuttling CB1 among different membrane microenvironments 149
Pharmacological folding chaperones act as allosteric ligands of Frizzled4 142
Discovery of 2,3-Diaminoindole Derivatives as a Novel Class of NOD Antagonists 141
Shooting for selective drug-like DNA G-quadruplex binders 141
Click-Chemistry (CuAAC) Trimerization of an αvβ6 Integrin Targeting Ga-68-Peptide: Enhanced Contrast for in-Vivo PET Imaging of Human Lung Adenocarcinoma Xenografts 141
Interfering with the Tumor-Immune Interface: Making Way for Triazine-Based Small Molecules as Novel PD-L1 Inhibitors 137
Analysis of quadruplex ligands by displacement isothermal titration calorimetry 133
Development and Nanoparticle-Mediated Delivery of Novel MDM2/MDM4 Heterodimer Peptide Inhibitors to Enhance 5-Fluorouracil Nucleolar Stress in Colorectal Cancer Cells 132
Exploring the N-Terminal Region of C-X-C Motif Chemokine 12 (CXCL12): Identification of Plasma-Stable Cyclic Peptides As Novel, Potent C-X-C Chemokine Receptor Type 4 (CXCR4) Antagonists 127
Targeting CXCR4 reverts the suppressive activity of T-regulatory cells in renal cancer 127
Beyond radio-displacement techniques for Identification of CB1 Ligands: The First Application of a Fluorescence-quenching Assay 126
Theoretical and experimental studies on the interaction of biphenyl ligands with human and murine PD-L1: Up-to-date clues for drug design 123
Targeting the Human Telomeric G-Quadruplex Through Virtual Screening Calculations 121
Long non-coding RNA containing ultraconserved genomic region 8 promotes bladder cancer tumorigenesis 120
Dual MET and SMO Negative Modulators Overcome Resistance to EGFR Inhibitors in Human Nonsmall Cell Lung Cancer 120
Paper-based electrochemical device for early detection of integrin αvβ6 expressing tumors 118
Structural and conformational requisites in DNA quadruplex groove binding: Another piece to the puzzle 116
Structure-Activity Relationships and Biological Characterization of a Novel, Potent, and Serum Stable C-X-C Chemokine Receptor Type 4 (CXCR4) Antagonist 115
Probing integrin selectivity: rational design of highly active and selective ligands for the alpha5beta1 and alphavbeta3 integrin receptor. 114
Structure-based lead optimization and biological evaluation of BAX direct activators as novel potential anticancer agents 113
Structural and Conformational Requisites in DNA Quadruplex Groove Binding 109
3-Aryl-[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-one: a novel template for the design of highly selective A2B adenosine receptor antagonists 109
A New DNA Structural Motif: The G-Triplex 109
A more detailed picture of the interactions between Virtual Screening-derived Hits and the DNA G-Quadruplex: NMR, Molecular Modeling and ITC Studies 109
Shooting for selective drug-like G-quadruplex binders: Evidence for telomeric DNA damage and tumor cell death 109
A combined approach of structure‐based virtual screening and NMR to interrupt the PD‐1/PD‐L1 axis: Biphenyl‐benzimidazole containing compounds as novel PD‐L1 inhibitors 108
Shooting for selective druglike G-quadruplex binders: evidence for telomeric DNA damage and tumor cell death 108
From a Helix to a Small Cycle: Metadynamics-Inspired αvβ6 Integrin Selective Ligands 108
Disulfide bond replacement with 1,4‐ and 1,5‐disubstituted [1,2,3]‐triazole on C‐X‐C chemokine receptor type 4 (CXCR4) peptide ligands: small changes that make big differences 108
Enriching the arsenal of pharmacological tools against mical2 107
Novel Quinolinonyl Diketo Acid Derivatives as HIV-1 Integrase Inhibitors: Design, Synthesis, and Biological Activities 106
Progresses in the pursuit of aldose reductase inhibitors: the structure-based lead optimization step. 106
Ligand-Based NMR Study of C-X-C Chemokine Receptor Type 4 (CXCR4)-Ligand Interactions on Living Cancer Cells 106
New Indole Tubulin Assembly Inhibitors Cause Stable Arrest of Mitotic Progression, Enhanced Stimulation of Natural Killer Cell Cytotoxic Activity, and Repression of Hedgehog-Dependent Cancer 105
A more detailed picture of the interactions between virtual screening-derived hits and the DNA G-quadruplex: NMR, molecular modelling and ITC studies. 104
State-of-the-art methodologies for the discovery and characterization of DNA G-Quadruplex binders 104
Identification of a Novel p53 Modulator Endowed with Antitumoural and Antibacterial Activity through a Scaffold Repurposing Approach 103
Shooting for Selective Drug-Like DNA G-Quadruplex Binders 103
Chemical modifications in the seed region of miRNAs 221/222 increase the silencing performances in gastrointestinal stromal tumor cells 103
Novel peptidomimetics as BACE-1 inhibitors: synthesis, molecular modeling, and biological studies 101
Boosting Fmoc Solid-Phase Peptide Synthesis by Ultrasonication 100
Ensemble-docking approach on BACE-1: pharmacophore perception and guidelines for drug design 97
Long lasting inhibition of Mdm2-p53 interaction potentiates mesenchymal stem cell differentiation into osteoblasts 97
Simultaneous Targeting of RGD-Integrins and Dual Murine Double Minute Proteins in Glioblastoma Multiforme 96
Deepening bis-(thio)carbohydrazones conformational dynamics and hydrogen bond interactions in a non-protic solvent: DFT, molecular dynamics, NMR, and Raman investigations 95
Specific Targeting of Highly Conserved Residues in the HIV-1 Reverse Transcriptase Primer Grip Region. 2. Stereoselective Interaction to Overcome the Effects of Drug Resistant Mutations 95
New 2-Heterocyclyl-imidazo[2,1-i]purin-5-one Derivatives as Potent and Selective Human A3Adenosine Receptor Antagonists 95
Benzofuroxane Derivatives as Multi-Effective Agents for the Treatment of Cardiovascular Diabetic Complications. Synthesis, Functional Evaluation, and Molecular Modeling Studies 94
Elucidating the Binding Behavior of Highly Potent COX-2 Selective Inhibitors 94
Targeting the KRAS oncogene: Synthesis, physicochemical and biological evaluation of novel G-Quadruplex DNA binders 94
Design, synthesis and biological evaluation of novel TRβ selective agonists sustained by ADME-toxicity analysis 93
Breaking the dogma of the metal-coordinating carboxylate group in integrin ligands: introducing hydroxamic acids to the MIDAS to tune potency and selectivity 92
Bax Activation Blocks Self-Renewal and Induces Apoptosis of Human Glioblastoma Stem Cells 92
Pharmacological targeting of smoothened receptor cysteine-rich domain by Budesonide promotes in vitro myelination 91
Acetic Acid Aldose Reductase Inhibitors Bearing a Five-Membered Heterocyclic Core with Potent Topical Activity in a Visual Impairment Rat Model. 90
Deepening the Topology of the Translocator Protein Binding Site by Novel N,N-Dialkyl-2-arylindol-3-ylglyoxylamides 90
Minute-timescale free-energy calculations reveal a pseudo-active state in the adenosine A2A receptor activation mechanism 89
Human integrin αvβ5: homology modeling and ligand binding. 89
A stereoselective approach to peptidomimetic BACE1 inhibitors 89
Basic Quinolinonyl Diketo Acid Derivatives as Inhibitors of HIV Integrase and their Activity against RNase H Function of Reverse Transcriptase 89
Halting the Spread of Herpes Simplex Virus-1: The Discovery of an Effective Dual αvβ6/αvβ8 Integrin Ligand 89
Applicazione di Metodologie Computazionali nella Scoperta e Sviluppo di Nuovi Agenti per il Trattamento delle Malattie Parassitarie 87
Water-Soluble Pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines as Human A(3) Adenosine Receptor Antagonists 86
Design, Synthesis, and Biological Evaluation of 1-Phenylpyrazolo[3,4-e]pyrrolo[3,4-g]indolizine-4,6(1H,5H)-diones as New Glycogen Synthase Kinase-3 beta Inhibitors 86
Challenging clinically unresponsive medullary thyroid cancer: Discovery and pharmacological activity of novel RET inhibitors 86
Human recombinant beta-secretase immobilized enzyme reactor for fast hits' selection and characterization from a virtual screening library 85
N-O-ISOPROPYL SULFONAMIDO-BASED HYDROXAMATES: KINETIC CHARACTERISATION OF A SERIES OF MMP-12/MMP-13 DUAL TARGET INHIBITORS. 85
3-Aryl-[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-one: a novel template for the design of highly selective A2B adenosine receptor antagonists 85
Stable Peptides Instead of Stapled Peptides: Highly Potent αvβ6-Selective Integrin Ligands 85
Novel N2-substituted pyrazolo[3,4-d]pyrimidine adenosine A3 receptor antagonists: inhibition of A3-mediated human glioblastoma cell proliferation 84
Identification of novel molecular scaffolds for the design of MMP-13 inhibitors: A first round of lead optimization. 84
Biselectivity of isoDGR Peptides for Fibronectin Binding Integrin Subtypes α5β1 and αvβ6: Conformational Control through Flanking Amino Acids 84
The G-triplex DNA 83
Ex.50.T aptamer impairs tumor–stroma cross-talk in breast cancer by targeting gremlin-1 82
Design, Synthesis, and Biological Evaluation of Novel Aminobisphosphonates Possessing an in Vivo Antitumor Activity Through a γδ -T Lymphocytes-Mediated Activation Mechanism. 82
Tandem Application of Virtual Screening and NMR Experiments in the Discovery of Brand New DNA Quaduplex Groove Binders 82
UT RECEPTOR LIGANDS. SWITCHING FROM AGONIST TO ANTAGONIST ACTIVITY 82
Protein Flexibility in Virtual Screening: The BACE-1 Case Study 82
Discovery of Covalent Inhibitors of Glyceraldehyde-3-phosphate Dehydrogenase, A Target for the Treatment of Malaria 82
Overcoming the Lack of Oral Availability of Cyclic Hexapeptides: Design of a Selective and Orally Available Ligand for the Integrin αvβ3 82
Conformational Control of Integrin-Subtype Selectivity in isoDGR Peptide Motifs: A Biological Switch. 81
Phenylpyrazolo[1,5-a]quinazolin-5(4H)-one: a suitable scaffold for the development of non-camptothecin Topoisomerase I (Top1) inhibitors. 81
The ring residue proline 8 is crucial for the thermal stability of the lasso peptide caulosegnin II 81
Isocyanides as Catalytic Electron Acceptors in the Visible Light Promoted Oxidative Formation of Benzyl and Acyl Radicals 80
Dual binding mode of SC-558 in COX-2: A new frontier in COX inhibition 80
Homology Modeling of NR2B Modulatory Domain of NMDA Receptor and Analysis of Ifenprodil Binding. 79
Synthesis, Molecular Modeling and mu-Opioid Receptor Affinity of 9,10-Diazatricyclo[4.2.1.12,5] decanes and 2,7-Diazatricyclo[4.4.0.03,8]decanes Structurally Related to 3,8-Diazabicyclo[3.2.1]octanes 79
Dual binding mode of SC-558 in COX-2: A new frontier in COX inhibition 79
Interfering with HuR-RNA Interaction: Design, Synthesis and Biological Characterization of Tanshinone Mimics as Novel, Effective HuR Inhibitors 79
Synthesis, biological activity and molecular modeling of new biphenylic carboxamides as potent and selective CB2 receptor ligands 78
The organometallic ferrocene exhibits amplified anti-tumor activity by targeted delivery via highly selective ligands to αvβ3, αvβ6, or α5β1 integrins 77
CXCR4 antagonism sensitizes cancer cells to novel indole-based MDM2/4 inhibitors in glioblastoma multiforme 77
Totale 10.588
Salva come PNG Salva come JPEG
Categoria #
all - tutte 51.551
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 51.551
Salva come PNG Salva come JPEG


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021277 0 0 0 0 0 0 42 27 67 17 79 45
2021/2022854 16 3 8 8 16 22 15 41 177 75 94 379
2022/20231.334 173 77 35 146 138 146 0 127 179 209 74 30
2023/2024799 50 106 119 54 43 53 34 119 12 15 133 61
2024/20254.813 218 301 27 73 101 284 487 338 366 453 1.707 458
2025/20265.534 1.015 692 1.086 765 1.558 364 54 0 0 0 0 0
Totale 15.409