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FROECHLICH, GUENDALINA

FROECHLICH, GUENDALINA  

DIPARTIMENTO DI MEDICINA MOLECOLARE E BIOTECNOLOGIE MEDICHE  

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A long non-coding SINEUP RNA boosts semi-stable production of fully human monoclonal antibodies in HEK293E cells 1.1 Articolo in rivista 2018 Sasso, Emanuele; Latino, Debora; Froechlich, Guendalina; Succoio, Mariangela; Passariello, Margherita; De Lorenzo, Claudia; Nicosia, Alfredo; Zambrano, Nicola
Novel Human Anti-PD-L1 mAbs Inhibit Immune-Independent Tumor Cell Growth and PD-L1 Associated Intracellular Signalling 1.1 Articolo in rivista 2019 Passariello, M; D'Alise, Am; Esposito, A; Vetrei, C; Froechlich, Guendalina; Scarselli, E; Nicosia, A; De Lorenzo, C.
Generation of a novel mesothelin-targeted oncolytic herpes virus and implemented strategies for manufacturing 1.1 Articolo in rivista 2021 Froechlich, G.; Gentile, C.; Infante, L.; Caiazza, C.; Pagano, P.; Scatigna, S.; Cotugno, G.; D'Alise, A. M.; Lahm, A.; Scarselli, E.; Nicosia, A.; Mallardo, M.; Sasso, E.; Zambrano, N.
Integrity of the antiviral STING-mediated DNA sensing in tumor cells is required to sustain the immunotherapeutic efficacy of herpes simplex oncolytic virus 1.1 Articolo in rivista 2020 Froechlich, G.; Caiazza, C.; Gentile, C.; D'Alise, A. M.; De Lucia, M.; Langone, F.; Leoni, G.; Cotugno, G.; Scisciola, V.; Nicosia, A.; Scarselli, E.; Mallardo, M.; Sasso, E.; Zambrano, N.
Retargeted and Multi-cytokine-Armed Herpes Virus Is a Potent Cancer Endovaccine for Local and Systemic Anti-tumor Treatment 1.1 Articolo in rivista 2020 De Lucia, M.; Cotugno, G.; Bignone, V.; Garzia, I.; Nocchi, L.; Langone, F.; Petrovic, B.; Sasso, E.; Pepe, S.; Froechlich, G.; Gentile, C.; Zambrano, N.; Campadelli-Fiume, G.; Nicosia, A.; Scarselli, E.; D'Alise, A. M.
Replicative conditioning of Herpes simplex type 1 virus by Survivin promoter, combined to ERBB2 retargeting, improves tumour cell-restricted oncolysis 1.1 Articolo in rivista 2020 Sasso, E.; Froechlich, G.; Cotugno, G.; D'Alise, A. M.; Gentile, C.; Bignone, V.; De Lucia, M.; Petrovic, B.; Campadelli-Fiume, G.; Scarselli, E.; Nicosia, A.; Zambrano, N.
Isolation of Two Novel Human Anti-CTLA-4 mAbs with Intriguing Biological Properties on Tumor and NK Cells 1.1 Articolo in rivista 2020 Passariello, M; Vetrei, C; Sasso, E; Froechlich, G; Gentile, C; D'Alise, Am; Zambrano, N; Scarselli, E; Nicosia, A; De Lorenzo, C.
Generation of a retargeted oncolytic herpes virus encoding adenosine deaminase for tumor adenosine clearance 1.1 Articolo in rivista 2021 Gentile, C.; Finizio, A.; Froechlich, G.; D'Alise, A. M.; Cotugno, G.; Amiranda, S.; Nicosia, A.; Scarselli, E.; Zambrano, N.; Sasso, E.
High-Throughput Monoclonal Antibody Discovery from Phage Libraries: Challenging the Current Preclinical Pipeline to Keep the Pace with the Increasing mAb Demand 1.1 Articolo in rivista 2022 Zambrano, Nicola; Froechlich, Guendalina; Lazarevic, Dejan; Passariello, Margherita; Nicosia, Alfredo; De Lorenzo, Claudia; Morelli, Marco J.; Sasso, Emanuele
Immunomodulatory mabs as tools to investigate on cis-interaction of pd-1/pd-l1 on tumor cells and to set up methods for early screening of safe and potent combinatorial treatments 1.1 Articolo in rivista 2021 Vetrei, C.; Passariello, M.; Froechlich, G.; Lembo, R. R.; Zambrano, N.; De Lorenzo, C.
Novel combinations of human immunomodulatory mAbs lacking cardiotoxic effects for therapy of TNBC 1.1 Articolo in rivista 2022 Vetrei, C.; Passariello, M.; Froechlich, G.; Lembo, R. R.; Sasso, E.; Zambrano, N.; De Lorenzo, C.
New Insights on the Role of Anti-PD-L1 and Anti-CTLA-4 mAbs on Different Lymphocytes Subpopulations in TNBC 1.1 Articolo in rivista 2022 Lembo, R. R.; Manna, L.; Froechlich, G.; Sasso, E.; Passariello, M.; De Lorenzo, C.
Massive parallel screening of phage libraries for the generation of repertoires of human immunomodulatory monoclonal antibodies. 1.1 Articolo in rivista 2018 Sasso, E; D'Avino, C; Passariello, M; D'Alise, Am; Siciliano, D; Esposito, Ml; Froechlich, Guendalina; Cortese, R; Scarselli, E; Zambrano, N; Nicosia, A; De Lorenzo, C.
The common H232 STING allele shows impaired activities in DNA sensing, susceptibility to viral infection, and in monocyte cell function, while the HAQ variant possesses wild-type properties 1.1 Articolo in rivista 2023 Froechlich, Guendalina; Finizio, Arianna; Napolano, Alessandra; Amiranda, Sara; De Chiara, Arianna; Pagano, Pasqualina; Mallardo, Massimo; Leoni, Guido; Zambrano, Nicola; Sasso, Emanuele
Prime and pull of Tcell responses against cancer-exogenous antigens is effective against CPI-resistant tumors 1.1 Articolo in rivista 2024 Troise, Fulvia; Leoni, Guido; Sasso, Emanuele; Del Sorbo, Mariarosaria; Esposito, Marialuisa; Romano, Giuseppina; Allocca, Simona; Froechlich, Guendalina; Cotugno, Gabriella; Capone, Stefania; Folgori, Antonella; Scarselli, Elisa; Morena D’Alise, Anna; Nicosia, Alfredo
Integrating system biology and intratumor gene therapy by trans-complementing the appropriate co-stimulatory molecule as payload in oncolytic herpes virus 1.1 Articolo in rivista 2024 Finizio, A.; Pagano, P.; Napolano, A.; Froechlich, G.; Infante, L.; De Chiara, A.; Amiranda, S.; Vitiello, E.; Totaro, S.; Capasso, C.; Raia, M.; D’Alise, A. M.; de Candia, P.; Zambrano, N.; Sasso, E.