IRIS
BRINDISI, MARGHERITA
 Distribuzione geografica
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Continente #
AS - Asia 2.780
EU - Europa 2.018
NA - Nord America 1.967
SA - Sud America 324
AF - Africa 60
OC - Oceania 2
Continente sconosciuto - Info sul continente non disponibili 1
Totale 7.152
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Nazione #
US - Stati Uniti d'America 1.893
SG - Singapore 1.707
RU - Federazione Russa 985
IT - Italia 552
CN - Cina 463
HK - Hong Kong 307
BR - Brasile 268
VN - Vietnam 126
IE - Irlanda 90
DE - Germania 89
FI - Finlandia 62
GB - Regno Unito 49
CA - Canada 45
NL - Olanda 43
FR - Francia 35
IN - India 29
AR - Argentina 27
MX - Messico 20
BE - Belgio 19
KR - Corea 19
IQ - Iraq 18
CI - Costa d'Avorio 17
JP - Giappone 17
SE - Svezia 17
BD - Bangladesh 15
UA - Ucraina 15
ZA - Sudafrica 15
TR - Turchia 12
ID - Indonesia 11
PL - Polonia 11
AT - Austria 9
ES - Italia 8
RS - Serbia 7
TW - Taiwan 7
EC - Ecuador 6
JO - Giordania 6
PT - Portogallo 6
KE - Kenya 5
LT - Lituania 5
PK - Pakistan 5
CO - Colombia 4
DK - Danimarca 4
EG - Egitto 4
IR - Iran 4
PY - Paraguay 4
TN - Tunisia 4
VE - Venezuela 4
AL - Albania 3
BF - Burkina Faso 3
KG - Kirghizistan 3
KZ - Kazakistan 3
MA - Marocco 3
MY - Malesia 3
NP - Nepal 3
UY - Uruguay 3
UZ - Uzbekistan 3
AE - Emirati Arabi Uniti 2
AU - Australia 2
AZ - Azerbaigian 2
CL - Cile 2
CR - Costa Rica 2
DO - Repubblica Dominicana 2
GE - Georgia 2
GF - Guiana Francese 2
GR - Grecia 2
IL - Israele 2
PE - Perù 2
PS - Palestinian Territory 2
SK - Slovacchia (Repubblica Slovacca) 2
AM - Armenia 1
AO - Angola 1
BB - Barbados 1
BG - Bulgaria 1
BO - Bolivia 1
BW - Botswana 1
CY - Cipro 1
DM - Dominica 1
ET - Etiopia 1
EU - Europa 1
GH - Ghana 1
GY - Guiana 1
IS - Islanda 1
LA - Repubblica Popolare Democratica del Laos 1
LC - Santa Lucia 1
LU - Lussemburgo 1
LV - Lettonia 1
MD - Moldavia 1
MM - Myanmar 1
MN - Mongolia 1
NA - Namibia 1
NE - Niger 1
PA - Panama 1
PH - Filippine 1
SA - Arabia Saudita 1
SN - Senegal 1
SY - Repubblica araba siriana 1
TH - Thailandia 1
TT - Trinidad e Tobago 1
TZ - Tanzania 1
ZM - Zambia 1
Totale 7.152
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Città #
Singapore 774
Hong Kong 300
Moscow 263
Chandler 237
Santa Clara 187
Naples 173
Beijing 163
Millbury 147
Hefei 112
Ashburn 111
Lawrence 72
Des Moines 62
Los Angeles 52
Redondo Beach 46
Ho Chi Minh City 37
Dublin 35
Hanoi 35
Buffalo 34
Napoli 31
Wilmington 30
Princeton 28
San Jose 28
Dallas 27
Düsseldorf 27
Ottawa 27
The Dalles 27
Nanjing 26
Boston 25
Amsterdam 23
Rome 21
Seattle 20
Brussels 19
Seoul 19
São Paulo 18
Jacksonville 17
Lappeenranta 17
Frankfurt am Main 16
New York 16
Lauterbourg 13
Tokyo 12
Helsinki 11
Mexico City 11
Falkenstein 10
Milan 10
Woodbridge 10
Baghdad 9
Belo Horizonte 9
Bologna 9
Chicago 9
Lucca 9
Nanchang 9
Salerno 9
Torre del Greco 9
Munich 8
Orem 8
Phoenix 8
Portsmouth 8
Rio de Janeiro 8
San Francisco 8
San Giorgio a Cremano 8
Warsaw 8
Denver 7
Haiphong 7
Marigliano 7
Palermo 7
Pomigliano d'Arco 7
Amman 6
Ankara 6
Changsha 6
Chennai 6
Delhi 6
Guangzhou 6
Houston 6
Tianjin 6
Toronto 6
Turku 6
Brasília 5
Cesano Boscone 5
Curitiba 5
Elk Grove Village 5
Falls Church 5
Florence 5
London 5
Marcianise 5
Nairobi 5
Norwalk 5
Ribeirão Preto 5
Siena 5
Ann Arbor 4
Biên Hòa 4
Brooklyn 4
Cape Town 4
Casoria 4
Dong Ket 4
Emeryville 4
Enfield 4
Fairfield 4
Fremont 4
Kunming 4
Miami 4
Totale 3.718
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Nome #
Broad-spectrum coronavirus 3C-like protease peptidomimetic inhibitors effectively block SARS-CoV-2 replication in cells: Design, synthesis, biological evaluation, and X-ray structure determination 145
Continuous-Flow Technology for Chemical Rearrangements: A Powerful Tool to Generate Pharmaceutically Relevant Compounds 136
Tackling triple negative breast cancer with HDAC inhibitors: 6 is the isoform! 135
Harnessing interrupted Fischer in continuous flow: sustainable synthesis of (spiro)indolenine and (spiro)indoline privileged scaffolds 127
A First-in-Class Pyrazole-isoxazole Enhanced Antifungal Activity of Voriconazole: Synergy Studies in an Azole-Resistant Candida albicans Strain, Computational Investigation and in Vivo Validation in a Galleria mellonella Fungal Infection Model 123
Rejuvenating the [1, 2, 3]-triazolo [1,5-a]quinoxalin-4(5H)-one scaffold: Synthesis and derivatization in a sustainable guise and preliminary antimicrobial evaluation 113
Photo-Flow Technology for Chemical Rearrangements: A Powerful Tool to Generate Pharmaceutically Relevant Compounds 112
Urea Derivatives in Modern Drug Discovery and Medicinal Chemistry 111
Chasing a Breath of Fresh Air in Cystic Fibrosis (CF): Therapeutic Potential of Selective HDAC6 Inhibitors to Tackle Multiple Pathways in CF Pathophysiology 106
Synthesis and biological evaluation of fluorinated 1,5-diarylpyrrole-3-alkoxyethyl ether derivatives as selective COX-2 inhibitors endowed with anti-inflammatory activity 105
Novel peptidomimetics as BACE-1 inhibitors: synthesis, molecular modeling, and biological studies 101
Unveiling the modulation of Pseudomonas aeruginosa virulence and biofilm formation by selective histone deacetylase 6 inhibitors 97
Specific Targeting of Highly Conserved Residues in the HIV-1 Reverse Transcriptase Primer Grip Region. 2. Stereoselective Interaction to Overcome the Effects of Drug Resistant Mutations 96
Novel, Potent, and Selective Quinoxaline-Based 5-HT3 Receptor Ligands. 1: Further Structure-Activity Relationships and Pharmacological Characterization 96
Easy access to α-ketoamides as SARS-CoV-2 and MERS Mpro inhibitors via the PADAM oxidation route 95
Methyl-Transferase-Like Protein 16 (METTL16): The Intriguing Journey of a Key Epitranscriptomic Player Becoming an Emerging Biological Target 93
A stereoselective approach to peptidomimetic BACE1 inhibitors 92
Efficacy of selective histone deacetylase 6 inhibition in mouse models of Pseudomonas aeruginosa infection: A new glimpse for reducing inflammation and infection in cystic fibrosis 88
An efficient approach to chiral C8/C9-piperazino-substituted 1,4-benzodiazepin-2-ones as peptidomimetic scaffolds. 86
Exploiting protein fluctuation at human cholinesterase active-sites. New Perspectives 85
Disease-Modifying Anti-Alzheimer's Drugs: Inhibitors of Human Cholinesterases Interfering with?-Amyloid Aggregation 84
Breakthroughs in medicinal chemistry: New targets and mechanisms, new drugs, new hopes-7 83
Flow synthesis approaches to privileged scaffolds - recent routes reviewed for green and sustainable aspects 83
Pyrroloquinoxaline hydrazones as fluorescent probes for amyloid fibrils 82
Synthesis and Antiplasmodial Activity of Bicyclic Dioxanes as Simplified Dihydroplakortin Analogues 82
The Structural Evolution of beta-Secretase Inhibitors: A Focus on the Development of Small-Molecule Inhibitors 80
Coupling Interrupted Fischer and Multicomponent Joullié-Ugi to Chase Chemical Diversity: from Batch to Sustainable Flow Synthesis of Peptidomimetics 80
Enantioselective binding of second generation pyrrolobenzoxazepinones to the catalytic ternary complex of HIV-1 RT wild-type and L100I and K103N drug resistant mutants 78
A synthetic strategy to bridged 2,3,8-trioxabicyclo[3,3,1]nonane endoperoxides 76
Selective Kainate Receptor (GluK1) Ligands Structurally Based upon 1H-Cyclopentapyrimidin-2,4(1H,3H)-dione: Synthesis, Molecular Modeling, and Pharmacological and Biostructural Characterization 76
Site-directed Mutagenesis of Key Residues Unveiled a Novel Allosteric Site on Human Adenosine Kinase for Pyrrolobenzoxa(thia)zepinone Non-Nucleoside Inhibitors 76
Discovery of potent nucleotide-mimicking competitive inhibitors of hepatitis C virus NS3 helicase. 75
Multifunctional Cholinesterase and Amyloid Beta Fibrillization Modulators. Synthesis and Biological Investigation 75
A stereoselective route to 6-substituted pyrrolo-1,5-benzoxazepinones and their analogues 74
Mimicking the Intramolecular Hydrogen Bond: Synthesis, Biological Evaluation, and Molecular Modeling of Benzoxazines and Quinazolines as Potential Antimalarial Agents 74
From (+)-epigallocatechin gallate to a simplified synthetic analogue as a cytoadherence inhibitor for P. falciparum 74
Development of Potent Inhibitors of the Mycobacterium tuberculosis Virulence Factor Zmp1 and Evaluation of Their Effect on Mycobacterial Survival inside Macrophages 72
Design, Synthesis and Structure-Activity Relationship Studies of 4-Quinolinyl- and 9-Acrydinylhydrazones as Potent Antimalarial Agents 71
Quinolylhydrazones as novel inhibitors of Plasmodium falciparum serine protease PfSUB1 70
Enantioselective catalytic Strecker reaction on cyclic (Z)-aldimines in flow: reaction optimization and sustainability aspects 68
Editorial: Multi-target directed ligands for the treatment of cancer 67
Development of novel multipotent compounds modulating endocannabinoid and dopaminergic systems 67
HCV-targeted Antivirals: Current Status and Future Challenges 66
Structure-based discovery of the first non-covalent inhibitors of Leishmania major tryparedoxin peroxidase by high throughput docking 64
Non-nucleoside inhibitors of human adenosine kinase: synthesis, molecular modeling, and biological studies. 62
Raising the bar in anticancer therapy: recent advances in, and perspectives on, telomerase inhibitors 61
Exploiting Protein Fluctuations at the Active-Site Gorge of Human Cholinesterases: Further Optimization of the Design Strategy to Develop Extremely Potent Inhibitors. 60
Antimalarial agents against both sexual and asexual parasites stages: structure-activity relationships and biological studies of the Malaria Box compound 1-[5-(4-bromo-2-chlorophenyl)furan-2-yl]- N -[(piperidin-4-yl)methyl]methanamine (MMV019918) and analogues 60
Design, synthesis, X-ray studies, and biological evaluation of novel macrocyclic HIV-1 protease inhibitors involving the P1'-P2' ligands 60
Design and Synthesis of Highly Potent HIV-1 Protease Inhibitors Containing Tricyclic Fused Ring Systems as Novel P2 Ligands: Structure-Activity Studies, Biological and X-ray Structural Analysis 59
Old but Gold: Tracking the New Guise of Histone Deacetylase 6 (HDAC6) Enzyme as a Biomarker and Therapeutic Target in Rare Diseases 58
Mechanochemical Fischer indolisation: an eco-friendly design for a timeless reaction 57
Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain 57
Asymmetric Diels-Alder reaction of 3-(acyloxy)acryloyl oxazolidinones: Optically active synthesis of a high-affinity ligand for potent HIV-1 protease inhibitors 57
Novel spiroindoline HDAC inhibitors: Synthesis, molecular modelling and biological studies 56
Design of novel HIV-1 protease inhibitors incorporating isophthalamide-derived P2-P3 ligands: Synthesis, biological evaluation and X-ray structural studies of inhibitor-HIV-1 protease complex 56
Design, synthesis, X-ray studies, and biological evaluation of novel BACE1 inhibitors with bicyclic isoxazoline carboxamides as the P3 ligand 55
Autophagy modulators for the treatment of oral and esophageal squamous cell carcinomas 55
Spiroindoline-Capped Selective HDAC6 Inhibitors: Design, Synthesis, Structural Analysis, and Biological Evaluation 55
A green Heck reaction protocol towards trisubstituted alkenes, versatile pharmaceutical intermediates 54
Design, Synthesis, Biological Evaluation, and X‐ray Studies of HIV‐1 Protease Inhibitors with Modified P2′ Ligands of Darunavir 54
Exploring clotrimazole-based pharmacophore: 3D-QSAR studies and synthesis of novel antiplasmodial agents 54
Bridged bicyclic 2,3-dioxabicyclo[3.3.1]nonanes as antiplasmodial agents: Synthesis, structure-activity relationships and studies on their biomimetic reaction with Fe(II) 54
Telomerase-based cancer therapeutics: A review on their clinical trials 54
Amide Bonds Meet Flow Chemistry: A Journey into Methodologies and Sustainable Evolution 54
Design of Highly Potent, Dual-Acting and Central-Nervous-System-Penetrating HIV-1 Protease Inhibitors with Excellent Potency against Multidrug-Resistant HIV-1 Variants 53
iPSC-derived neurons profiling reveals GABAergic circuit disruption and acetylated α-tubulin defect which improves after iHDAC6 treatment in Rett syndrome 52
Achmatowicz reaction and its application in the syntheses of bioactive molecules 52
Synthetic studies toward bicyclic endoperoxides presenting polar side chains 52
Harnessing the pyrroloquinoxaline scaffold for FAAH and MAGL interaction: Definition of the structural determinants for enzyme inhibition 51
Development of a practical and scalable route for the preparation of the deacetoxytubuvaline (dTuv) fragment of pretubulysin and analogs 51
Phenylpyrrole-based HDAC inhibitors: synthesis, molecular modeling and biological studies 51
Organic Carbamates in Drug Design and Medicinal Chemistry 51
Dealing with schistosomiasis: Current drug discovery strategies 51
The Curtius Rearrangement: Applications in Modern Drug Discovery and Medicinal Chemistry 50
Drug Development and Medicinal Chemistry Efforts toward SARS-Coronavirus and Covid-19 Therapeutics 50
Novel quinolone-based potent and selective HDAC6 inhibitors: Synthesis, molecular modeling studies and biological investigation 50
Targeting clinically-relevant metallo-β-lactamases: from high-throughput docking to broad-spectrum inhibitors 49
In silico study of subtilisin-like protease 1 (SUB1) from different Plasmodium species in complex with peptidyl-difluorostatones and characterization of potent pan-SUB1 inhibitors 49
Polypharmacology of dopamine receptor ligands 49
The Curtius rearrangement: mechanistic insight and recent applications in natural product syntheses 49
A Jocic-type approach for a practical and scalable synthesis of pyrrolonaphthoxazepine (PNOX)-based potent proapoptotic agents 49
Developing β-secretase inhibitors for treatment of Alzheimer’s disease 48
Allosteric Modulation of Ionotropic Glutamate Receptors: An Outlook on New Therapeutic Approaches To Treat Central Nervous System Disorders 48
Development of Potent Inhibitors of Fatty Acid Amide Hydrolase Useful for the Treatment of Neuropathic Pain 48
Design, synthesis, and X-ray structural studies of BACE-1 inhibitors containing substituted 2-oxopiperazines as P1 '-P2 ' ligands 48
Development of novel cyclic peptides as pro-apoptotic agents 48
Highly Selective and Potent Human β-Secretase 2 (BACE2) Inhibitors against Type 2 Diabetes: Design, Synthesis, X-ray Structure and Structure–Activity Relationship Studies 47
First dual AK/GSK-3β inhibitors endowed with antioxidant properties as multifunctional, potential neuroprotective agents 46
Identification of Novel 3-Hydroxy-pyran-4-One Derivatives as Potent HIV-1 Integrase Inhibitors Using in silico Structure-Based Combinatorial Library Design Approach 46
Identification of a novel arylpiperazine scaffold for fatty acid amide hydrolase inhibition with improved drug disposition properties 45
A light in the dark: State of the art and perspectives in optogenetics and optopharmacology for restoring vision 45
Computational tool for fast in silico evaluation of hERG K+ channel affinity 45
The novel pyrrolo-1,5-benzoxazepine, PBOX-21, potentiates the apoptotic efficacy of STI571 (imatinib mesylate) in human chronic myeloid leukaemia cells 44
Identification of novel fluorescent probes preventing PrP(Sc) replication in prion diseases 44
Activation of the Wnt pathway by small peptides: rational design, synthesis and biological evaluation 44
Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents 44
Nature Inspired Molecular Design: Stereoselective Synthesis of Bicyclic and Polycyclic Ethers for Potent HIV-1 Protease Inhibitors 43
Multitarget compounds bearing tacrine- and donepezil-like structural and functional motifs for the potential treatment of Alzheimer's disease 43
Selective targeting of the HIV-1 reverse transcriptase catalytic complex through interaction with the "primer grip" region by pyrrolobenzoxazepinone non-nucleoside inhibitors correlates with increased activity towards drug-resistant mutants 42
Totale 6.808
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Categoria #
all - tutte 26.415
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 26.415
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021112 0 0 0 0 0 0 11 16 39 31 11 4
2021/2022452 1 0 9 1 6 23 2 17 49 34 51 259
2022/2023646 108 17 8 60 77 66 11 73 131 25 45 25
2023/2024469 20 56 79 92 12 12 8 23 7 19 107 34
2024/20252.638 159 208 8 57 47 211 341 135 249 226 786 211
2025/20262.598 424 441 439 346 703 203 42 0 0 0 0 0
Totale 7.360