IRIS
BRINDISI, MARGHERITA
 Distribuzione geografica
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Continente #
NA - Nord America 1.436
EU - Europa 672
AS - Asia 472
AF - Africa 16
SA - Sud America 5
Continente sconosciuto - Info sul continente non disponibili 1
Totale 2.602
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Nazione #
US - Stati Uniti d'America 1.404
IT - Italia 394
SG - Singapore 328
CN - Cina 110
IE - Irlanda 90
FI - Finlandia 47
CA - Canada 32
NL - Olanda 26
GB - Regno Unito 23
DE - Germania 22
BE - Belgio 16
CI - Costa d'Avorio 15
SE - Svezia 12
UA - Ucraina 11
IN - India 10
RU - Federazione Russa 9
RS - Serbia 6
PT - Portogallo 5
HK - Hong Kong 4
IR - Iran 4
VN - Vietnam 4
BR - Brasile 3
FR - Francia 3
IQ - Iraq 3
JP - Giappone 3
AR - Argentina 2
ES - Italia 2
GR - Grecia 2
PL - Polonia 2
TR - Turchia 2
TW - Taiwan 2
EU - Europa 1
KG - Kirghizistan 1
LT - Lituania 1
LV - Lettonia 1
MM - Myanmar 1
ZM - Zambia 1
Totale 2.602
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Città #
Singapore 266
Chandler 237
Santa Clara 183
Millbury 147
Naples 111
Ashburn 74
Lawrence 72
Des Moines 62
Dublin 35
Beijing 33
Napoli 31
Wilmington 30
Princeton 28
Nanjing 26
Ottawa 26
Amsterdam 19
Boston 19
Lappeenranta 17
Brussels 16
Jacksonville 16
Rome 14
Seattle 11
Nanchang 9
Salerno 9
Woodbridge 9
Marigliano 7
Milan 7
Pomigliano d'Arco 7
Falls Church 5
Florence 5
Moscow 5
Norwalk 5
Palermo 5
Siena 5
Tianjin 5
Ann Arbor 4
Bologna 4
Delhi 4
Dong Ket 4
Emeryville 4
Enfield 4
Fairfield 4
Guangzhou 4
Houston 4
Kunming 4
Mugnano di Napoli 4
Porto 4
West Lafayette 4
Baronissi 3
Cagliari 3
Changsha 3
Hangzhou 3
Kronberg 3
Offanengo 3
Redwood City 3
Rimini 3
Shenyang 3
Waterford 3
Afragola 2
Belgrade 2
Belo Horizonte 2
Boardman 2
Cambridge 2
Catania 2
Genova 2
Hayes 2
Hebei 2
Helsinki 2
Hong Kong 2
Jiaxing 2
Koblenz 2
Madrid 2
Matera 2
Messina 2
Mohali 2
Munro 2
New Taipei City 2
Novi Sad 2
Qualiano 2
Romainville 2
San Francisco 2
San Valentino Torio 2
Seymour 2
Springfield 2
Taizhou 2
Tehran 2
Toronto 2
Torre Annunziata 2
Winnipeg 2
Zola Predosa 2
Aversa 1
Baghdad 1
Bishkek 1
Casoria 1
Castel Volturno 1
Como 1
Dallas 1
Darmstadt 1
Dearborn 1
Delta 1
Totale 1.712
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Nome #
Harnessing interrupted Fischer in continuous flow: sustainable synthesis of (spiro)indolenine and (spiro)indoline privileged scaffolds 59
Breakthroughs in medicinal chemistry: New targets and mechanisms, new drugs, new hopes-7 54
Design, Synthesis and Structure-Activity Relationship Studies of 4-Quinolinyl- and 9-Acrydinylhydrazones as Potent Antimalarial Agents 43
Easy access to α-ketoamides as SARS-CoV-2 and MERS Mpro inhibitors via the PADAM oxidation route 41
Broad-spectrum coronavirus 3C-like protease peptidomimetic inhibitors effectively block SARS-CoV-2 replication in cells: Design, synthesis, biological evaluation, and X-ray structure determination 40
Continuous-Flow Technology for Chemical Rearrangements: A Powerful Tool to Generate Pharmaceutically Relevant Compounds 39
Synthesis and biological evaluation of fluorinated 1,5-diarylpyrrole-3-alkoxyethyl ether derivatives as selective COX-2 inhibitors endowed with anti-inflammatory activity 39
Novel peptidomimetics as BACE-1 inhibitors: synthesis, molecular modeling, and biological studies 38
Urea Derivatives in Modern Drug Discovery and Medicinal Chemistry 38
Specific Targeting of Highly Conserved Residues in the HIV-1 Reverse Transcriptase Primer Grip Region. 2. Stereoselective Interaction to Overcome the Effects of Drug Resistant Mutations 37
Novel, Potent, and Selective Quinoxaline-Based 5-HT3 Receptor Ligands. 1: Further Structure-Activity Relationships and Pharmacological Characterization 36
Structure-based discovery of the first non-covalent inhibitors of Leishmania major tryparedoxin peroxidase by high throughput docking 36
Development of novel multipotent compounds modulating endocannabinoid and dopaminergic systems 36
Chasing a Breath of Fresh Air in Cystic Fibrosis (CF): Therapeutic Potential of Selective HDAC6 Inhibitors to Tackle Multiple Pathways in CF Pathophysiology 36
An efficient approach to chiral C8/C9-piperazino-substituted 1,4-benzodiazepin-2-ones as peptidomimetic scaffolds. 35
Non-nucleoside inhibitors of human adenosine kinase: synthesis, molecular modeling, and biological studies. 35
Raising the bar in anticancer therapy: recent advances in, and perspectives on, telomerase inhibitors 35
Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain 35
Tackling triple negative breast cancer with HDAC inhibitors: 6 is the isoform! 33
Rejuvenating the [1, 2, 3]-triazolo [1,5-a]quinoxalin-4(5H)-one scaffold: Synthesis and derivatization in a sustainable guise and preliminary antimicrobial evaluation 32
Editorial: Multi-target directed ligands for the treatment of cancer 32
Asymmetric Diels-Alder reaction of 3-(acyloxy)acryloyl oxazolidinones: Optically active synthesis of a high-affinity ligand for potent HIV-1 protease inhibitors 32
Photo-Flow Technology for Chemical Rearrangements: A Powerful Tool to Generate Pharmaceutically Relevant Compounds 30
Efficacy of selective histone deacetylase 6 inhibition in mouse models of Pseudomonas aeruginosa infection: A new glimpse for reducing inflammation and infection in cystic fibrosis 30
Exploiting Protein Fluctuations at the Active-Site Gorge of Human Cholinesterases: Further Optimization of the Design Strategy to Develop Extremely Potent Inhibitors. 30
Achmatowicz reaction and its application in the syntheses of bioactive molecules 30
Design, synthesis, X-ray studies, and biological evaluation of novel macrocyclic HIV-1 protease inhibitors involving the P1'-P2' ligands 30
Phenylpyrrole-based HDAC inhibitors: synthesis, molecular modeling and biological studies 30
Bridged bicyclic 2,3-dioxabicyclo[3.3.1]nonanes as antiplasmodial agents: Synthesis, structure-activity relationships and studies on their biomimetic reaction with Fe(II) 30
Autophagy modulators for the treatment of oral and esophageal squamous cell carcinomas 30
Antimalarial agents against both sexual and asexual parasites stages: structure-activity relationships and biological studies of the Malaria Box compound 1-[5-(4-bromo-2-chlorophenyl)furan-2-yl]- N -[(piperidin-4-yl)methyl]methanamine (MMV019918) and analogues 29
Novel spiroindoline HDAC inhibitors: Synthesis, molecular modelling and biological studies 29
Old but Gold: Tracking the New Guise of Histone Deacetylase 6 (HDAC6) Enzyme as a Biomarker and Therapeutic Target in Rare Diseases 29
Design, synthesis, X-ray studies, and biological evaluation of novel BACE1 inhibitors with bicyclic isoxazoline carboxamides as the P3 ligand 28
Synthetic studies toward bicyclic endoperoxides presenting polar side chains 28
Amide Bonds Meet Flow Chemistry: A Journey into Methodologies and Sustainable Evolution 28
Design, Synthesis, Biological Evaluation, and X‐ray Studies of HIV‐1 Protease Inhibitors with Modified P2′ Ligands of Darunavir 27
Exploring clotrimazole-based pharmacophore: 3D-QSAR studies and synthesis of novel antiplasmodial agents 27
Design of Highly Potent, Dual-Acting and Central-Nervous-System-Penetrating HIV-1 Protease Inhibitors with Excellent Potency against Multidrug-Resistant HIV-1 Variants 27
Drug Development and Medicinal Chemistry Efforts toward SARS-Coronavirus and Covid-19 Therapeutics 27
Pyrroloquinoxaline hydrazones as fluorescent probes for amyloid fibrils 26
Site-directed Mutagenesis of Key Residues Unveiled a Novel Allosteric Site on Human Adenosine Kinase for Pyrrolobenzoxa(thia)zepinone Non-Nucleoside Inhibitors 26
Development of a practical and scalable route for the preparation of the deacetoxytubuvaline (dTuv) fragment of pretubulysin and analogs 26
In silico study of subtilisin-like protease 1 (SUB1) from different Plasmodium species in complex with peptidyl-difluorostatones and characterization of potent pan-SUB1 inhibitors 26
Design and Synthesis of Highly Potent HIV-1 Protease Inhibitors Containing Tricyclic Fused Ring Systems as Novel P2 Ligands: Structure-Activity Studies, Biological and X-ray Structural Analysis 26
The Curtius Rearrangement: Applications in Modern Drug Discovery and Medicinal Chemistry 26
Synthesis and Antiplasmodial Activity of Bicyclic Dioxanes as Simplified Dihydroplakortin Analogues 25
Targeting clinically-relevant metallo-β-lactamases: from high-throughput docking to broad-spectrum inhibitors 25
The Curtius rearrangement: mechanistic insight and recent applications in natural product syntheses 25
Flow synthesis approaches to privileged scaffolds - recent routes reviewed for green and sustainable aspects 25
A stereoselective approach to peptidomimetic BACE1 inhibitors 24
From (+)-epigallocatechin gallate to a simplified synthetic analogue as a cytoadherence inhibitor for P. falciparum 24
The Structural Evolution of beta-Secretase Inhibitors: A Focus on the Development of Small-Molecule Inhibitors 24
Design of novel HIV-1 protease inhibitors incorporating isophthalamide-derived P2-P3 ligands: Synthesis, biological evaluation and X-ray structural studies of inhibitor-HIV-1 protease complex 24
Allosteric Modulation of Ionotropic Glutamate Receptors: An Outlook on New Therapeutic Approaches To Treat Central Nervous System Disorders 24
A Jocic-type approach for a practical and scalable synthesis of pyrrolonaphthoxazepine (PNOX)-based potent proapoptotic agents 24
Dealing with schistosomiasis: Current drug discovery strategies 24
Telomerase-based cancer therapeutics: A review on their clinical trials 24
Coupling Interrupted Fischer and Multicomponent Joullié-Ugi to Chase Chemical Diversity: from Batch to Sustainable Flow Synthesis of Peptidomimetics 24
Harnessing the pyrroloquinoxaline scaffold for FAAH and MAGL interaction: Definition of the structural determinants for enzyme inhibition 23
Exploiting protein fluctuation at human cholinesterase active-sites. New Perspectives 23
Identification of a novel arylpiperazine scaffold for fatty acid amide hydrolase inhibition with improved drug disposition properties 23
A light in the dark: State of the art and perspectives in optogenetics and optopharmacology for restoring vision 23
Activation of the Wnt pathway by small peptides: rational design, synthesis and biological evaluation 23
First dual AK/GSK-3β inhibitors endowed with antioxidant properties as multifunctional, potential neuroprotective agents 23
Development of Potent Inhibitors of the Mycobacterium tuberculosis Virulence Factor Zmp1 and Evaluation of Their Effect on Mycobacterial Survival inside Macrophages 23
Computational tool for fast in silico evaluation of hERG K+ channel affinity 23
Development of novel cyclic peptides as pro-apoptotic agents 23
A stereoselective route to 6-substituted pyrrolo-1,5-benzoxazepinones and their analogues 22
Disease-Modifying Anti-Alzheimer's Drugs: Inhibitors of Human Cholinesterases Interfering with?-Amyloid Aggregation 22
Development of Potent Inhibitors of Fatty Acid Amide Hydrolase Useful for the Treatment of Neuropathic Pain 22
Highly Selective and Potent Human β-Secretase 2 (BACE2) Inhibitors against Type 2 Diabetes: Design, Synthesis, X-ray Structure and Structure–Activity Relationship Studies 22
Organic Carbamates in Drug Design and Medicinal Chemistry 22
Novel quinolone-based potent and selective HDAC6 inhibitors: Synthesis, molecular modeling studies and biological investigation 22
Spiroindoline-Capped Selective HDAC6 Inhibitors: Design, Synthesis, Structural Analysis, and Biological Evaluation 22
Mechanochemical Fischer indolisation: an eco-friendly design for a timeless reaction 21
Selective Kainate Receptor (GluK1) Ligands Structurally Based upon 1H-Cyclopentapyrimidin-2,4(1H,3H)-dione: Synthesis, Molecular Modeling, and Pharmacological and Biostructural Characterization 21
Design, synthesis, and X-ray structural studies of BACE-1 inhibitors containing substituted 2-oxopiperazines as P1 '-P2 ' ligands 21
Enantioselective binding of second generation pyrrolobenzoxazepinones to the catalytic ternary complex of HIV-1 RT wild-type and L100I and K103N drug resistant mutants 20
Mimicking the Intramolecular Hydrogen Bond: Synthesis, Biological Evaluation, and Molecular Modeling of Benzoxazines and Quinazolines as Potential Antimalarial Agents 20
(S)-2-Amino-3-(5-methyl-3-hydroxyisoxazol-4-yl)propanoic Acid (AMPA) and Kainate Receptor Ligands: further exploration of bioisosteric replacements and structural and biological investigation 20
Selective targeting of the HIV-1 reverse transcriptase catalytic complex through interaction with the "primer grip" region by pyrrolobenzoxazepinone non-nucleoside inhibitors correlates with increased activity towards drug-resistant mutants 19
A synthetic strategy to bridged 2,3,8-trioxabicyclo[3,3,1]nonane endoperoxides 19
iPSC-derived neurons profiling reveals GABAergic circuit disruption and acetylated α-tubulin defect which improves after iHDAC6 treatment in Rett syndrome 19
Nature Inspired Molecular Design: Stereoselective Synthesis of Bicyclic and Polycyclic Ethers for Potent HIV-1 Protease Inhibitors 19
Developing β-secretase inhibitors for treatment of Alzheimer’s disease 19
Identification of Novel 3-Hydroxy-pyran-4-One Derivatives as Potent HIV-1 Integrase Inhibitors Using in silico Structure-Based Combinatorial Library Design Approach 19
Discovery of potent nucleotide-mimicking competitive inhibitors of hepatitis C virus NS3 helicase. 18
Quinolylhydrazones as novel inhibitors of Plasmodium falciparum serine protease PfSUB1 18
Multifunctional Cholinesterase and Amyloid Beta Fibrillization Modulators. Synthesis and Biological Investigation 18
Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents 18
HCV-targeted Antivirals: Current Status and Future Challenges 17
Structure-based design, synthesis and biological evaluation of novel β-secretase inhibitors containing a pyrazole or thiazole moiety as the P3 ligand 17
Multitarget compounds bearing tacrine- and donepezil-like structural and functional motifs for the potential treatment of Alzheimer's disease 17
Plasmodium falciparum subtilisin-like protease 1: Discovery of potent difluorostatone-based inhibitors 17
A First-in-Class Pyrazole-isoxazole Enhanced Antifungal Activity of Voriconazole: Synergy Studies in an Azole-Resistant Candida albicans Strain, Computational Investigation and in Vivo Validation in a Galleria mellonella Fungal Infection Model 16
Discovery of a New Class of Potential Multifunctional Atypical Antipsychotic Agents Targeting Dopamine D3 and Serotonin 5-HT1A and 5-HT2A Receptors: Design, Synthesis, and Effects on Behavior 16
The novel pyrrolo-1,5-benzoxazepine, PBOX-21, potentiates the apoptotic efficacy of STI571 (imatinib mesylate) in human chronic myeloid leukaemia cells 16
Identification of novel fluorescent probes preventing PrP(Sc) replication in prion diseases 16
Unconventional Knoevenagel-type indoles: Synthesis and cell-based studies for the identification of pro-apoptotic agents 15
Totale 2.649
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Categoria #
all - tutte 14.288
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 14.288
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/202066 0 0 0 0 0 5 1 1 2 17 30 10
2020/2021258 5 2 25 7 88 19 11 16 39 31 11 4
2021/2022452 1 0 9 1 6 23 2 17 49 34 51 259
2022/2023646 108 17 8 60 77 66 11 73 131 25 45 25
2023/2024469 20 56 79 92 12 12 8 23 7 19 107 34
2024/2025681 159 208 8 57 47 202 0 0 0 0 0 0
Totale 2.805