IRIS
BRINDISI, MARGHERITA
 Distribuzione geografica
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Continente #
AS - Asia 3.670
NA - Nord America 2.869
EU - Europa 2.351
SA - Sud America 364
Continente sconosciuto - Info sul continente non disponibili 219
AF - Africa 77
OC - Oceania 5
Totale 9.555
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Nazione #
US - Stati Uniti d'America 2.749
SG - Singapore 1.773
RU - Federazione Russa 986
IT - Italia 720
CN - Cina 611
VN - Vietnam 543
HK - Hong Kong 337
BR - Brasile 287
FR - Francia 148
DE - Germania 94
IE - Irlanda 92
CA - Canada 67
FI - Finlandia 66
IN - India 66
JP - Giappone 65
BD - Bangladesh 61
GB - Regno Unito 59
NL - Olanda 53
IQ - Iraq 34
AR - Argentina 32
MX - Messico 28
KR - Corea 26
BE - Belgio 20
TH - Thailandia 20
UA - Ucraina 20
PH - Filippine 18
SE - Svezia 18
CI - Costa d'Avorio 17
PK - Pakistan 16
TR - Turchia 16
ZA - Sudafrica 16
TW - Taiwan 15
ES - Italia 12
ID - Indonesia 12
PL - Polonia 12
JO - Giordania 10
AT - Austria 9
CO - Colombia 8
EC - Ecuador 8
RS - Serbia 8
PT - Portogallo 7
VE - Venezuela 7
CR - Costa Rica 6
JM - Giamaica 6
MA - Marocco 6
TN - Tunisia 6
UZ - Uzbekistan 6
AU - Australia 5
CL - Cile 5
KE - Kenya 5
LT - Lituania 5
NP - Nepal 5
UY - Uruguay 5
DK - Danimarca 4
EG - Egitto 4
IR - Iran 4
KZ - Kazakistan 4
PY - Paraguay 4
SC - Seychelles 4
AL - Albania 3
BF - Burkina Faso 3
CH - Svizzera 3
ET - Etiopia 3
KG - Kirghizistan 3
MY - Malesia 3
PE - Perù 3
AE - Emirati Arabi Uniti 2
AZ - Azerbaigian 2
BO - Bolivia 2
BW - Botswana 2
DO - Repubblica Dominicana 2
DZ - Algeria 2
GE - Georgia 2
GF - Guiana Francese 2
GR - Grecia 2
IL - Israele 2
LB - Libano 2
MD - Moldavia 2
MN - Mongolia 2
PR - Porto Rico 2
PS - Palestinian Territory 2
SK - Slovacchia (Repubblica Slovacca) 2
AM - Armenia 1
AO - Angola 1
AW - Aruba 1
BB - Barbados 1
BG - Bulgaria 1
CY - Cipro 1
CZ - Repubblica Ceca 1
DM - Dominica 1
EU - Europa 1
GH - Ghana 1
GT - Guatemala 1
GY - Guiana 1
HT - Haiti 1
IS - Islanda 1
KW - Kuwait 1
LA - Repubblica Popolare Democratica del Laos 1
LC - Santa Lucia 1
LU - Lussemburgo 1
Totale 9.321
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Città #
Singapore 824
San Jose 415
Hong Kong 318
Naples 268
Moscow 263
Chandler 237
Ashburn 220
Santa Clara 209
Beijing 180
Millbury 147
Ho Chi Minh City 145
Hanoi 135
Lauterbourg 116
Hefei 112
The Dalles 94
Lawrence 72
Los Angeles 64
Des Moines 63
Tokyo 55
Redondo Beach 46
Buffalo 39
Dublin 37
Dallas 36
Napoli 31
New York 31
Wilmington 31
Haiphong 30
Ottawa 28
Princeton 28
Düsseldorf 27
Boston 26
Nanjing 26
Orem 26
Amsterdam 24
São Paulo 24
Rome 23
Brussels 20
Da Nang 20
Frankfurt am Main 20
Lappeenranta 20
Milan 20
Seattle 20
Seoul 20
Jacksonville 18
Baghdad 17
Chennai 16
Council Bluffs 13
Denver 13
Toronto 13
Helsinki 12
Mexico City 12
Chicago 11
Belo Horizonte 10
Brooklyn 10
Falkenstein 10
Guangzhou 10
Phoenix 10
Woodbridge 10
Bologna 9
Florence 9
Lucca 9
Montreal 9
Nanchang 9
Palermo 9
Rio de Janeiro 9
Salerno 9
San Francisco 9
Torre del Greco 9
Warsaw 9
Amman 8
Bangkok 8
Biên Hòa 8
Houston 8
London 8
Munich 8
Portsmouth 8
San Giorgio a Cremano 8
Atlanta 7
Delhi 7
Marigliano 7
Pomigliano d'Arco 7
Tianjin 7
Ankara 6
Changsha 6
Curitiba 6
Manchester 6
New Delhi 6
Ninh Bình 6
Shanghai 6
Thái Bình 6
Turku 6
Wuhan 6
Brasília 5
Cape Town 5
Cesano Boscone 5
Elk Grove Village 5
Falls Church 5
Lahore 5
Marcianise 5
Mercato San Severino 5
Totale 5.073
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Nome #
Broad-spectrum coronavirus 3C-like protease peptidomimetic inhibitors effectively block SARS-CoV-2 replication in cells: Design, synthesis, biological evaluation, and X-ray structure determination 177
Tackling triple negative breast cancer with HDAC inhibitors: 6 is the isoform! 169
A First-in-Class Pyrazole-isoxazole Enhanced Antifungal Activity of Voriconazole: Synergy Studies in an Azole-Resistant Candida albicans Strain, Computational Investigation and in Vivo Validation in a Galleria mellonella Fungal Infection Model 159
Continuous-Flow Technology for Chemical Rearrangements: A Powerful Tool to Generate Pharmaceutically Relevant Compounds 154
Harnessing interrupted Fischer in continuous flow: sustainable synthesis of (spiro)indolenine and (spiro)indoline privileged scaffolds 143
Urea Derivatives in Modern Drug Discovery and Medicinal Chemistry 140
Unveiling the modulation of Pseudomonas aeruginosa virulence and biofilm formation by selective histone deacetylase 6 inhibitors 139
Rejuvenating the [1, 2, 3]-triazolo [1,5-a]quinoxalin-4(5H)-one scaffold: Synthesis and derivatization in a sustainable guise and preliminary antimicrobial evaluation 136
Photo-Flow Technology for Chemical Rearrangements: A Powerful Tool to Generate Pharmaceutically Relevant Compounds 132
Novel peptidomimetics as BACE-1 inhibitors: synthesis, molecular modeling, and biological studies 128
Chasing a Breath of Fresh Air in Cystic Fibrosis (CF): Therapeutic Potential of Selective HDAC6 Inhibitors to Tackle Multiple Pathways in CF Pathophysiology 128
Synthesis and biological evaluation of fluorinated 1,5-diarylpyrrole-3-alkoxyethyl ether derivatives as selective COX-2 inhibitors endowed with anti-inflammatory activity 127
A stereoselective approach to peptidomimetic BACE1 inhibitors 119
Efficacy of selective histone deacetylase 6 inhibition in mouse models of Pseudomonas aeruginosa infection: A new glimpse for reducing inflammation and infection in cystic fibrosis 118
Novel, Potent, and Selective Quinoxaline-Based 5-HT3 Receptor Ligands. 1: Further Structure-Activity Relationships and Pharmacological Characterization 112
Specific Targeting of Highly Conserved Residues in the HIV-1 Reverse Transcriptase Primer Grip Region. 2. Stereoselective Interaction to Overcome the Effects of Drug Resistant Mutations 110
Methyl-Transferase-Like Protein 16 (METTL16): The Intriguing Journey of a Key Epitranscriptomic Player Becoming an Emerging Biological Target 109
Exploiting protein fluctuation at human cholinesterase active-sites. New Perspectives 108
Breakthroughs in medicinal chemistry: New targets and mechanisms, new drugs, new hopes-7 107
Easy access to α-ketoamides as SARS-CoV-2 and MERS Mpro inhibitors via the PADAM oxidation route 105
Flow synthesis approaches to privileged scaffolds - recent routes reviewed for green and sustainable aspects 103
Site-directed Mutagenesis of Key Residues Unveiled a Novel Allosteric Site on Human Adenosine Kinase for Pyrrolobenzoxa(thia)zepinone Non-Nucleoside Inhibitors 100
Coupling Interrupted Fischer and Multicomponent Joullié-Ugi to Chase Chemical Diversity: from Batch to Sustainable Flow Synthesis of Peptidomimetics 100
An efficient approach to chiral C8/C9-piperazino-substituted 1,4-benzodiazepin-2-ones as peptidomimetic scaffolds. 99
Synthesis and Antiplasmodial Activity of Bicyclic Dioxanes as Simplified Dihydroplakortin Analogues 97
A stereoselective route to 6-substituted pyrrolo-1,5-benzoxazepinones and their analogues 94
Multifunctional Cholinesterase and Amyloid Beta Fibrillization Modulators. Synthesis and Biological Investigation 94
Disease-Modifying Anti-Alzheimer's Drugs: Inhibitors of Human Cholinesterases Interfering with?-Amyloid Aggregation 93
Quinolylhydrazones as novel inhibitors of Plasmodium falciparum serine protease PfSUB1 91
Selective Kainate Receptor (GluK1) Ligands Structurally Based upon 1H-Cyclopentapyrimidin-2,4(1H,3H)-dione: Synthesis, Molecular Modeling, and Pharmacological and Biostructural Characterization 91
Pyrroloquinoxaline hydrazones as fluorescent probes for amyloid fibrils 90
A synthetic strategy to bridged 2,3,8-trioxabicyclo[3,3,1]nonane endoperoxides 90
Development of Potent Inhibitors of the Mycobacterium tuberculosis Virulence Factor Zmp1 and Evaluation of Their Effect on Mycobacterial Survival inside Macrophages 90
Enantioselective binding of second generation pyrrolobenzoxazepinones to the catalytic ternary complex of HIV-1 RT wild-type and L100I and K103N drug resistant mutants 89
From (+)-epigallocatechin gallate to a simplified synthetic analogue as a cytoadherence inhibitor for P. falciparum 89
The Structural Evolution of beta-Secretase Inhibitors: A Focus on the Development of Small-Molecule Inhibitors 89
Enantioselective catalytic Strecker reaction on cyclic (Z)-aldimines in flow: reaction optimization and sustainability aspects 88
Mimicking the Intramolecular Hydrogen Bond: Synthesis, Biological Evaluation, and Molecular Modeling of Benzoxazines and Quinazolines as Potential Antimalarial Agents 88
Discovery of potent nucleotide-mimicking competitive inhibitors of hepatitis C virus NS3 helicase. 87
Antimalarial agents against both sexual and asexual parasites stages: structure-activity relationships and biological studies of the Malaria Box compound 1-[5-(4-bromo-2-chlorophenyl)furan-2-yl]- N -[(piperidin-4-yl)methyl]methanamine (MMV019918) and analogues 87
Design, Synthesis and Structure-Activity Relationship Studies of 4-Quinolinyl- and 9-Acrydinylhydrazones as Potent Antimalarial Agents 85
Old but Gold: Tracking the New Guise of Histone Deacetylase 6 (HDAC6) Enzyme as a Biomarker and Therapeutic Target in Rare Diseases 79
Structure-based discovery of the first non-covalent inhibitors of Leishmania major tryparedoxin peroxidase by high throughput docking 79
Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain 79
Development of novel multipotent compounds modulating endocannabinoid and dopaminergic systems 78
Exploiting Protein Fluctuations at the Active-Site Gorge of Human Cholinesterases: Further Optimization of the Design Strategy to Develop Extremely Potent Inhibitors. 77
HCV-targeted Antivirals: Current Status and Future Challenges 77
Spiroindoline-Capped Selective HDAC6 Inhibitors: Design, Synthesis, Structural Analysis, and Biological Evaluation 77
Editorial: Multi-target directed ligands for the treatment of cancer 76
Raising the bar in anticancer therapy: recent advances in, and perspectives on, telomerase inhibitors 76
Mechanochemical Fischer indolisation: an eco-friendly design for a timeless reaction 75
Design, synthesis, X-ray studies, and biological evaluation of novel macrocyclic HIV-1 protease inhibitors involving the P1'-P2' ligands 74
The Curtius rearrangement: mechanistic insight and recent applications in natural product syntheses 74
Novel spiroindoline HDAC inhibitors: Synthesis, molecular modelling and biological studies 73
Design and Synthesis of Highly Potent HIV-1 Protease Inhibitors Containing Tricyclic Fused Ring Systems as Novel P2 Ligands: Structure-Activity Studies, Biological and X-ray Structural Analysis 73
Achmatowicz reaction and its application in the syntheses of bioactive molecules 72
Design of novel HIV-1 protease inhibitors incorporating isophthalamide-derived P2-P3 ligands: Synthesis, biological evaluation and X-ray structural studies of inhibitor-HIV-1 protease complex 72
Highly Selective and Potent Human β-Secretase 2 (BACE2) Inhibitors against Type 2 Diabetes: Design, Synthesis, X-ray Structure and Structure–Activity Relationship Studies 72
Non-nucleoside inhibitors of human adenosine kinase: synthesis, molecular modeling, and biological studies. 71
Design, synthesis, X-ray studies, and biological evaluation of novel BACE1 inhibitors with bicyclic isoxazoline carboxamides as the P3 ligand 71
Exploring clotrimazole-based pharmacophore: 3D-QSAR studies and synthesis of novel antiplasmodial agents 71
Telomerase-based cancer therapeutics: A review on their clinical trials 71
Design, Synthesis, Biological Evaluation, and X‐ray Studies of HIV‐1 Protease Inhibitors with Modified P2′ Ligands of Darunavir 70
Targeting clinically-relevant metallo-β-lactamases: from high-throughput docking to broad-spectrum inhibitors 70
Development of a practical and scalable route for the preparation of the deacetoxytubuvaline (dTuv) fragment of pretubulysin and analogs 70
Amide Bonds Meet Flow Chemistry: A Journey into Methodologies and Sustainable Evolution 70
Asymmetric Diels-Alder reaction of 3-(acyloxy)acryloyl oxazolidinones: Optically active synthesis of a high-affinity ligand for potent HIV-1 protease inhibitors 69
Phenylpyrrole-based HDAC inhibitors: synthesis, molecular modeling and biological studies 68
Bridged bicyclic 2,3-dioxabicyclo[3.3.1]nonanes as antiplasmodial agents: Synthesis, structure-activity relationships and studies on their biomimetic reaction with Fe(II) 68
Autophagy modulators for the treatment of oral and esophageal squamous cell carcinomas 68
Design of Highly Potent, Dual-Acting and Central-Nervous-System-Penetrating HIV-1 Protease Inhibitors with Excellent Potency against Multidrug-Resistant HIV-1 Variants 67
Novel quinolone-based potent and selective HDAC6 inhibitors: Synthesis, molecular modeling studies and biological investigation 67
Polypharmacology of dopamine receptor ligands 66
Allosteric Modulation of Ionotropic Glutamate Receptors: An Outlook on New Therapeutic Approaches To Treat Central Nervous System Disorders 66
The Curtius Rearrangement: Applications in Modern Drug Discovery and Medicinal Chemistry 66
A green Heck reaction protocol towards trisubstituted alkenes, versatile pharmaceutical intermediates 65
Development of Potent Inhibitors of Fatty Acid Amide Hydrolase Useful for the Treatment of Neuropathic Pain 65
Design, synthesis, and X-ray structural studies of BACE-1 inhibitors containing substituted 2-oxopiperazines as P1 '-P2 ' ligands 65
Synthetic studies toward bicyclic endoperoxides presenting polar side chains 63
A Jocic-type approach for a practical and scalable synthesis of pyrrolonaphthoxazepine (PNOX)-based potent proapoptotic agents 63
Organic Carbamates in Drug Design and Medicinal Chemistry 63
Development of novel cyclic peptides as pro-apoptotic agents 63
Drug Development and Medicinal Chemistry Efforts toward SARS-Coronavirus and Covid-19 Therapeutics 63
Challenging triple negative breast cancer through HDAC6 selective inhibition: Novel cap-group identification, structure-activity relationships, computational and biological studies 62
The novel pyrrolo-1,5-benzoxazepine, PBOX-21, potentiates the apoptotic efficacy of STI571 (imatinib mesylate) in human chronic myeloid leukaemia cells 62
Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents 62
Computational tool for fast in silico evaluation of hERG K+ channel affinity 62
iPSC-derived neurons profiling reveals GABAergic circuit disruption and acetylated α-tubulin defect which improves after iHDAC6 treatment in Rett syndrome 61
In silico study of subtilisin-like protease 1 (SUB1) from different Plasmodium species in complex with peptidyl-difluorostatones and characterization of potent pan-SUB1 inhibitors 61
Activation of the Wnt pathway by small peptides: rational design, synthesis and biological evaluation 61
Dealing with schistosomiasis: Current drug discovery strategies 61
Harnessing the pyrroloquinoxaline scaffold for FAAH and MAGL interaction: Definition of the structural determinants for enzyme inhibition 60
Identification of novel fluorescent probes preventing PrP(Sc) replication in prion diseases 60
Identification of Novel 3-Hydroxy-pyran-4-One Derivatives as Potent HIV-1 Integrase Inhibitors Using in silico Structure-Based Combinatorial Library Design Approach 59
Identification of a novel arylpiperazine scaffold for fatty acid amide hydrolase inhibition with improved drug disposition properties 58
Nature Inspired Molecular Design: Stereoselective Synthesis of Bicyclic and Polycyclic Ethers for Potent HIV-1 Protease Inhibitors 58
First dual AK/GSK-3β inhibitors endowed with antioxidant properties as multifunctional, potential neuroprotective agents 58
Developing β-secretase inhibitors for treatment of Alzheimer’s disease 58
Multitarget compounds bearing tacrine- and donepezil-like structural and functional motifs for the potential treatment of Alzheimer's disease 58
Targeting Dopamine D3and Serotonin 5-HT1Aand 5-HT2AReceptors for Developing Effective Antipsychotics: Synthesis, Biological Characterization, and Behavioral Studies 57
Totale 8.534
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Categoria #
all - tutte 33.482
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 33.482
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022451 0 0 9 1 6 23 2 17 49 34 51 259
2022/2023646 108 17 8 60 77 66 11 73 131 25 45 25
2023/2024469 20 56 79 92 12 12 8 23 7 19 107 34
2024/20252.638 159 208 8 57 47 211 341 135 249 226 786 211
2025/20264.592 424 441 439 346 703 203 447 333 679 262 128 187
2026/2027201 140 61 0 0 0 0 0 0 0 0 0 0
Totale 9.555