Natural killer cells are an essential component of the innate immune system and play a crucial role in immunity against malignancies, without, at difference with T cells, requiring antigen priming or inducing graft-versus-host-disease. Hence, Natural Killer cells can provide a valuable source of allogeneic “off-the-shelf” adoptive therapy and mediate major antileukemia effects, without inducing potentially lethal alloreactivity. Several cell sources have been used for producing and expanding large numbers of clinical-grade natural killer cells. In this review, we will discuss the advantages and challenges of Natural Killer cell-based therapeutic approaches for hematological malignancies, also exploring different strategies to potentiate their clinical application.
NK cells as adoptive cellular therapy for hematological malignancies: Advantages and hurdles / Caruso, Simona; De Angelis, Biagio; Carlomagno, Simona; Del Bufalo, Francesca; Sivori, Simona; Locatelli, Franco; Quintarelli, Concetta. - In: SEMINARS IN HEMATOLOGY. - ISSN 0037-1963. - 57:4(2020), pp. 175-184. [10.1053/j.seminhematol.2020.10.004]
NK cells as adoptive cellular therapy for hematological malignancies: Advantages and hurdles
Caruso, Simona;De Angelis, Biagio;Carlomagno, Simona;Locatelli, Franco;Quintarelli, Concetta
Ultimo
2020
Abstract
Natural killer cells are an essential component of the innate immune system and play a crucial role in immunity against malignancies, without, at difference with T cells, requiring antigen priming or inducing graft-versus-host-disease. Hence, Natural Killer cells can provide a valuable source of allogeneic “off-the-shelf” adoptive therapy and mediate major antileukemia effects, without inducing potentially lethal alloreactivity. Several cell sources have been used for producing and expanding large numbers of clinical-grade natural killer cells. In this review, we will discuss the advantages and challenges of Natural Killer cell-based therapeutic approaches for hematological malignancies, also exploring different strategies to potentiate their clinical application.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
