Calixarenes meet (TG4T)4 G-quadruplex: Exploring reciprocal interactions to develop innovative biotechnological applications

This study investigates, for the first time, the ability of calixarene ligands to interact with G-quadruplex (GQ) DNA assemblies, which play a critical role in many biological processes, including gene expression regulation, telomere maintenance, and the surveillance of genome stability and DNA repair mechanisms. Specifically, the interaction between two calix[4]arene compounds, featuring cationic or zwitterionic functional groups on their upper rim, and the parallel tetramolecular (TG4T)4 G-...

Can an active lifestyle maintain cognitive efficiency in older adults? A pilot study of the relationship between physical activity and graphic fluency

Background Physical activity (PA) significantly impacts brain function and counteracts age-related changes in cognitive and motor abilities. Methods This pilot study delved into exploring the cognitive benefits of PA in older adults, focusing on their fluency abilities. We assessed verbal and graphic fluency in 45 older participants (mean age = 68.11 ± 3.34 years) using the Fluency Test (FAS) and modified Five-Points Test (m-FPT). They were divided into Active and Sedentary based on Inte...

Seismic-resistant CFS walls braced with pre-tensioned UHS steel bars: Design and construction of a building mockup

The paper presents the design and the construction of a real mock-up two-story exhibition building having a load bearing cold-formed steel (CFS) structure, where the lateral force resisting system (LFRS) is represented by an innovative hybrid wall made of CFS studs and tracks laterally braced by ultra-high strength (UHS) steel pretensioned diagonal bars. The hybrid CFS wall represents the result of the Italian research project, named ECCELSA, aimed to develop a CFS LFRS wall capable to be use...

La posizione e il comune. Due studi sulla modernità