Benzodiazepine Derivatives and Uses Thereof in Medical Field

The invention concerns benzodiazepine derivatives of formula wherein Y it is SO2 or NR, wherein R is H or C1-C6 alkyl; X is H, C1-C12 alkyl, -CO, -SO, -SO2, or -CO-R2, SO-R2, SO2-R2, wherein R2 is selected from H, C1-C12 alkyl, (C3-C8 cycloalkyl) C0-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C2-C6 alkoxycarbonyl, phenyl, benzyl, naphtyl, biphenyl, or heterocycle, each para-, meta- or ortho-substituted independently of each other with 0 to 3 substituents selected from halogen, -CN, -NH2, -OH, -NO2, COOR3, wherein R3 is selected from H, C1-C12 alkyl, (C3-C8 cycloalkyl) C0-C6 alkyl, C1-C6 alkoxy, C2-C6 alkenyl, C2-C6 alkynyl, or C2-C6 alkoxy carbonyl; phenyl, benzyl, naphtyl, biphenyl, or heterocycle n is 0-6; R4 is selected from H, OH, COOH, CN, C1-C6 alkyl, C1-C6 alkoxy, C2-C6 alkenyl, C2-C6 alkynyl, C2-C6 alkoxycarbonyl, -CO, -SO, -SO2, or -CO-R5, SO-R5, SO2-R2, -OCO-R5, OSO-R5, SO2-R5, COOR5, SOOR5, SO2OR5, NHR5, NHCOR5, NHSO2R5, SR5, SCOR5, wherein R5 is selected from H, C1-C6 alkyl, C1-C6 alkoxy, C2-C6 alkenyl, C2-C6 alkynyl, or C2-C6 alkoxycarbonyl, phenyl, benzyl, naphtyl, biphenyl, or heterocycle, each para-, meta- or ortho-substituted independently of each other with 0 to 3 substituents selected from halogen, -CN, -NH2, OH, -NO2, COOR5', wherein R5 is selected from H, C1-C12 alkyl, (C3-C8 cycloalkyl) C0-C6 alkyl, phenyl, benzyl, naphtyl, biphenyl, or heterocycle, C1-C6 alkyl, C1-C6 alkoxy, C2-C6 alkenyl, C2-C6 alkynyl, or C2-C6 alkoxy carbonyl; R6 and R7 independently of each other are selected from the group consisting of H, OH, halogen, CN, NH2, NO2, COOR3, C1-C6 alkyl, C1-C6 alkoxy, C2-C6 alkenyl, C2-C6 alkynyl, and C2-C6 alkoxy carbonyl; R3 is H, C1-C6 alkyl C2-C6 alkenyl, C2-C6 alkynyl or physiologically acceptable salts and uses thereof in medical field, particularly as anti-tumoral agents.