1H-MRSI can provide in vivo information about specific metabolites in biological tissues. Main applications of this technique concern brain studies. However, routine clinical applications are still limited by a variety of factors such as the long acquisition time, the poor spatial resolution, the presence of undesired signals coming from water and fat, the difficulties in data-processing. These problems can be addressed with two different approaches: the design of new excitation pulses sequences, and the improvement of data-processing techniques. In this preliminary study the latter approach has been adopted. Echoes are acquired without any suppression pulses sequence: the undesired signal coming from water is attenuated by means of an opportune processing, using a filtering technique based on SVD. A specific algorithm for peaks detection based upon iterative fitting (VARPRO) was developed. Maps relative to the four main metabolites in the brain are reconstructed and presented
Use of Different Time Domain Techniques for Metabolite Maps Reconstruction in 1H MRSI / Sansone, Mario; Cesarelli, Mario; Bifulco, Paolo; Bracale, Marcello; G., Tedeschi; S., Bonavita; F., DI SALLE. - World Congress on Medical Physics and Biomedical Engineering:(2000), pp. WE-206-WE-207. (Intervento presentato al convegno World Congress on Medical Physics and Biomedical Engineering tenutosi a CHICAGO (USA) nel 22-27 luglio).
Use of Different Time Domain Techniques for Metabolite Maps Reconstruction in 1H MRSI
SANSONE, MARIO;CESARELLI, MARIO;BIFULCO, PAOLO;BRACALE, MARCELLO;
2000
Abstract
1H-MRSI can provide in vivo information about specific metabolites in biological tissues. Main applications of this technique concern brain studies. However, routine clinical applications are still limited by a variety of factors such as the long acquisition time, the poor spatial resolution, the presence of undesired signals coming from water and fat, the difficulties in data-processing. These problems can be addressed with two different approaches: the design of new excitation pulses sequences, and the improvement of data-processing techniques. In this preliminary study the latter approach has been adopted. Echoes are acquired without any suppression pulses sequence: the undesired signal coming from water is attenuated by means of an opportune processing, using a filtering technique based on SVD. A specific algorithm for peaks detection based upon iterative fitting (VARPRO) was developed. Maps relative to the four main metabolites in the brain are reconstructed and presentedI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
