We present in vivo tomographic 125I imaging of a mouse thyroid acquired with MediSPECT, a scanner developed at University & INFN Napoli, for SPECT studies on small animals with a small field of view (FoV) and high spatial resolution. MediSPECT is based on a fine pitch CdTe pixel detector, operating in single photon counting, (14×14 mm2, 256×256 square pixel of 55 μm side) and equipped with a high resolution collimators set. The 72 planar projections of a mouse thyroid (injected activity 31.8 MBq) for SPECT reconstruction have been acquired using a 300 μm tungsten pinhole (magnification 1.47 and a FoV of 9.6×9.6 mm2). A C software based on Ordered Subsets-Expectation Maximization (OSEM) algorithm has been used for SPECT reconstructions. The spatial resolution with the 300 μm pinhole is, in planar imaging, about 0.5 mm and, in tomographic imaging, about 1 mm. The MediSPECT scanner has a modular structure that allows for multimodal imaging: at present, a Fluorescence Reflectance Imaging head has been installed, for planar optical imaging in addition to SPECT imaging.
The MediSPECT Small Animal CdTe Scanner / Montesi, MARIA CRISTINA; Mettivier, Giovanni; S. A., Curion; Lauria, Adele; Russo, Paolo. - STAMPA. - 25/2:(2009), pp. 566-568. (Intervento presentato al convegno World Congress on Medical Physics and Biomedical Engineering tenutosi a Munich nel 7-12 Sep, 2009) [10.1007/978-3-642-03879-2_158].
The MediSPECT Small Animal CdTe Scanner
MONTESI, MARIA CRISTINA;METTIVIER, GIOVANNI;LAURIA, ADELE;RUSSO, PAOLO
2009
Abstract
We present in vivo tomographic 125I imaging of a mouse thyroid acquired with MediSPECT, a scanner developed at University & INFN Napoli, for SPECT studies on small animals with a small field of view (FoV) and high spatial resolution. MediSPECT is based on a fine pitch CdTe pixel detector, operating in single photon counting, (14×14 mm2, 256×256 square pixel of 55 μm side) and equipped with a high resolution collimators set. The 72 planar projections of a mouse thyroid (injected activity 31.8 MBq) for SPECT reconstruction have been acquired using a 300 μm tungsten pinhole (magnification 1.47 and a FoV of 9.6×9.6 mm2). A C software based on Ordered Subsets-Expectation Maximization (OSEM) algorithm has been used for SPECT reconstructions. The spatial resolution with the 300 μm pinhole is, in planar imaging, about 0.5 mm and, in tomographic imaging, about 1 mm. The MediSPECT scanner has a modular structure that allows for multimodal imaging: at present, a Fluorescence Reflectance Imaging head has been installed, for planar optical imaging in addition to SPECT imaging.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
