lntrodiiction: Human Mesenchymal stem cells (MSC) are gaining large attention in Tissue Engineering (TE) owing to their characteristics of selfrenewal and multipotentiality. In order to effectively use stem cells within a TE context novei strategies for controlling thieir behaviour are required. This of course needs a deeper understanding of what signals can trigger specific actions, the biological pinciples governing celi-sigiial interactions. Chemotaxis, for example, has been implicated in many physiological phenornena such as wound healing and morphogenesis. lndeed, one of the strategies of TE consists in recapitulating such phenomena. Therefore, it is of paramount importance to provide the correct bioactive signals in order to recruit specific cell types from the surroundings and instruct them to synthersize matrix according to a pre-deterrnined scheme. In this work we have designed an experimental set up in order io assess the role of stromal cell-derived Factor- I (SDF-I) on the migratory behaviour of MSC in a 3D environment.
The effect of sdf1 on the migratory behaviour of mesechymal stem cells in 3D collagen gel / Lannone, M; Ventre, Maurizio; Giannoni, P; Scaglione, S; Quarto, R; Netti, PAOLO ANTONIO. - (2009). (Intervento presentato al convegno International Society for Stem Cell Research, 7th annual meeting tenutosi a Centre Convencions Internacional Barcelona, Barcelona, Spagna (E) nel 8-11 Lugio, 2009).
The effect of sdf1 on the migratory behaviour of mesechymal stem cells in 3D collagen gel
VENTRE, MAURIZIO;NETTI, PAOLO ANTONIO
2009
Abstract
lntrodiiction: Human Mesenchymal stem cells (MSC) are gaining large attention in Tissue Engineering (TE) owing to their characteristics of selfrenewal and multipotentiality. In order to effectively use stem cells within a TE context novei strategies for controlling thieir behaviour are required. This of course needs a deeper understanding of what signals can trigger specific actions, the biological pinciples governing celi-sigiial interactions. Chemotaxis, for example, has been implicated in many physiological phenornena such as wound healing and morphogenesis. lndeed, one of the strategies of TE consists in recapitulating such phenomena. Therefore, it is of paramount importance to provide the correct bioactive signals in order to recruit specific cell types from the surroundings and instruct them to synthersize matrix according to a pre-deterrnined scheme. In this work we have designed an experimental set up in order io assess the role of stromal cell-derived Factor- I (SDF-I) on the migratory behaviour of MSC in a 3D environment.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
