As a part of our systematic study on secondary metabolites from marine organisms collected at Solomon Islands, we found a single specimen of the sponge Theonella swinhoei as an extraordinary source of anti-inflammatory cyclic cyclopeptides, such as perthamides C-K and solomonamides. Perthamides C-K are endowed of promising anti-inflammatory activity. The isolation of this small library of peptides allowed us to delineate a structure-activity relationship.
Theonella swinhoei as a source of anti-inflammatory cyclopeptides / Festa, Carmen; DE MARINO, Simona; D'Auria, MARIA VALERIA; Monti, M. C.; Bucci, Mariarosaria; Vellecco, Valentina; Debitus, C.; Zampella, Angela. - (2012). (Intervento presentato al convegno XXXIV CONVEGNO NAZIONALE DIVISIONE DI CHIMICA ORGANICA tenutosi a Pavia nel 10-14 settembre).
Theonella swinhoei as a source of anti-inflammatory cyclopeptides
FESTA, CARMEN;DE MARINO, SIMONA;D'AURIA, MARIA VALERIA;M. C. Monti;BUCCI, MARIAROSARIA;VELLECCO, VALENTINA;ZAMPELLA, ANGELA
2012
Abstract
As a part of our systematic study on secondary metabolites from marine organisms collected at Solomon Islands, we found a single specimen of the sponge Theonella swinhoei as an extraordinary source of anti-inflammatory cyclic cyclopeptides, such as perthamides C-K and solomonamides. Perthamides C-K are endowed of promising anti-inflammatory activity. The isolation of this small library of peptides allowed us to delineate a structure-activity relationship.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
