Some aspects concerning the mechanisms by which cyclodextrins (CD) affect the delivery features of polymer-based drug delivery systems were investigated. It was found that the addition of hydroxypropyl-??-cyclodextrin (HP??CD) affected the release rate of carvedilol (CAR) from hydrophilic matrices by acting on both matrix erosion rate and concentration profile of drug in the swollen layer. On the other hand, the co-encapsulation of insulin with HP??CD inside biodegradable microspheres decreased protein burst and release rate depending on formulation conditions.
Cyclodextrins as modulators of drug release from polymeric delivery systems / Quaglia, Fabiana; DE ROSA, Giuseppe; Ungaro, Francesca; Miro, Agnese; LA ROTONDA, MARIA IMMACOLATA. - (2004), pp. 745-748. ( 12th International Cyclodextrin Symposium Montpellier, France March 16-19, 2004).
Cyclodextrins as modulators of drug release from polymeric delivery systems
QUAGLIA, FABIANA;DE ROSA, GIUSEPPE;UNGARO, FRANCESCA;MIRO, AGNESE;LA ROTONDA, MARIA IMMACOLATA
2004
Abstract
Some aspects concerning the mechanisms by which cyclodextrins (CD) affect the delivery features of polymer-based drug delivery systems were investigated. It was found that the addition of hydroxypropyl-??-cyclodextrin (HP??CD) affected the release rate of carvedilol (CAR) from hydrophilic matrices by acting on both matrix erosion rate and concentration profile of drug in the swollen layer. On the other hand, the co-encapsulation of insulin with HP??CD inside biodegradable microspheres decreased protein burst and release rate depending on formulation conditions.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
