Zoledronic acid (ZOL), a third generation aminobisphosphonate (A-BP), is a drug whose potent anticancer activity is limited by its short plasma half-life and rapid uptake and accumulation within bone. We have recently proposed new delivery systems to avoid ZOL accumulation into the bone, thus improving extra-skeletal bioavailability. In this work, we have developed selfassembly PEGylated nanoparticles (NPs) containing ZOL. ZOL-containing NPs showed good technological characteristics and the possibility to be prepared before use. These NPs showed a higher anti-cancer activity, evaluated in nude mice xenografted with prostate cancer PC3 cells, compared with that induced by free ZOL. In addition, NPs induced, in a significant number of animals, the complete remission of tumour xenografts and an increase of survival time.
New self-assembling nanoparticles for bisphosphonate delivery in cancer / Salzano, Giuseppina; M., Marra; S., Zappavigna; M., Caraglia; M., Porru; C., Leonetti; A., Abbruzzese; LA ROTONDA, MARIA IMMACOLATA; DE ROSA, Giuseppe. - (2011), pp. 0-0. (Intervento presentato al convegno Annual workshop CRS Italy Chapter Nanostructured devices for drug delivery: From small molecules to biotech drugs. tenutosi a Roma nel 17-19 novembre 2011).
New self-assembling nanoparticles for bisphosphonate delivery in cancer.
SALZANO, GIUSEPPINA;LA ROTONDA, MARIA IMMACOLATA;DE ROSA, GIUSEPPE
2011
Abstract
Zoledronic acid (ZOL), a third generation aminobisphosphonate (A-BP), is a drug whose potent anticancer activity is limited by its short plasma half-life and rapid uptake and accumulation within bone. We have recently proposed new delivery systems to avoid ZOL accumulation into the bone, thus improving extra-skeletal bioavailability. In this work, we have developed selfassembly PEGylated nanoparticles (NPs) containing ZOL. ZOL-containing NPs showed good technological characteristics and the possibility to be prepared before use. These NPs showed a higher anti-cancer activity, evaluated in nude mice xenografted with prostate cancer PC3 cells, compared with that induced by free ZOL. In addition, NPs induced, in a significant number of animals, the complete remission of tumour xenografts and an increase of survival time.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
