Neurosporacrassa has revealed to be an excellent genetic, biochemical and cell biological model for studying almost any aspect of fungal and higher eukaryotic biology such as growth and development, enhanced by the recent availability of a fully sequenced and annotated genome. In the frame of our study to assess the sphingolipid profile of N. crassa and their relevance to its biology, we found a novel tetraglycosylatedglycosphingolipid, neurosporaside, characterized by a sugar portion whose structure is unique in that the sugar moiety linked to the ceramide is formed by a chain of three β-galactopyranoside residues, with a glucopyranoside α-linked to the outer galactopyranoside. Its unique structure was elucidated by extensive spectroscopic analysis.
Neurosporaside, a new tetraglycosilated sphingolipid from the fungus Neurospora crassa / Costantino, Valeria; Mangoni, Alfonso; Teta, Roberta; G., Kra Oz; O., Yarden. - STAMPA. - (2010), pp. P115-P115. (Intervento presentato al convegno XXXIII Convegno Nazionale della Divisione di Chimica Organica Società Chimica Italiana tenutosi a San Benedetto del Tronto (AP) nel 12-16 Settembre 2010).
Neurosporaside, a new tetraglycosilated sphingolipid from the fungus Neurospora crassa
COSTANTINO, VALERIA;MANGONI, ALFONSO;TETA, ROBERTA;
2010
Abstract
Neurosporacrassa has revealed to be an excellent genetic, biochemical and cell biological model for studying almost any aspect of fungal and higher eukaryotic biology such as growth and development, enhanced by the recent availability of a fully sequenced and annotated genome. In the frame of our study to assess the sphingolipid profile of N. crassa and their relevance to its biology, we found a novel tetraglycosylatedglycosphingolipid, neurosporaside, characterized by a sugar portion whose structure is unique in that the sugar moiety linked to the ceramide is formed by a chain of three β-galactopyranoside residues, with a glucopyranoside α-linked to the outer galactopyranoside. Its unique structure was elucidated by extensive spectroscopic analysis.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
