Hypertension causes several microvascular alterations, leading to inadequate blood supply to tissues and target-organ damage. The present study was aimed to investigate microvascular skin blood flow and related oscillations in hypertensive obese subjects. Twenty-eight controls and twenty-seven hypertensive patients were recruited from our Outpatient Clinics. Anthropometric measurements were evaluated and bioimpedance analysis was performed. Finally, skin microvascular blood flow was measured by a laser Doppler flowmeter and oscillations in blood flow were analyzed by power spectrum analysis. Newly diagnosed hypertensive subjects showed lower mean skin blood flow as well as lower related total power spectral density compared to the controls. In these patients, moreover, power spectral analysis of microvascular oscillations indicate a lower spectral density of the frequency component related to myogenic activity compared to controls. Therefore, hypertension appears to be associated to myogenic impairments, causing changes in microvascular modulation and tissue perfusion. ?????? 2014 IEEE.
Microvascular blood flow regulation impairments in hypertensive obese people / Mastantuono, T; Lapi, D; Battiloro, L; Cesarelli, Mario; D'Addio, Giovanni; Iuppariello, Luigi; Colantuoni, Antonio. - (2014), pp. 191-192. (Intervento presentato al convegno 8th Conference of the European Study Group on Cardiovascular Oscillations, ESGCO 2014 tenutosi a Trento nel 2014) [10.1109/ESGCO.2014.6847584].
Microvascular blood flow regulation impairments in hypertensive obese people
Lapi D;CESARELLI, MARIO;D'ADDIO, Giovanni;IUPPARIELLO, LUIGI;COLANTUONI, ANTONIO
2014
Abstract
Hypertension causes several microvascular alterations, leading to inadequate blood supply to tissues and target-organ damage. The present study was aimed to investigate microvascular skin blood flow and related oscillations in hypertensive obese subjects. Twenty-eight controls and twenty-seven hypertensive patients were recruited from our Outpatient Clinics. Anthropometric measurements were evaluated and bioimpedance analysis was performed. Finally, skin microvascular blood flow was measured by a laser Doppler flowmeter and oscillations in blood flow were analyzed by power spectrum analysis. Newly diagnosed hypertensive subjects showed lower mean skin blood flow as well as lower related total power spectral density compared to the controls. In these patients, moreover, power spectral analysis of microvascular oscillations indicate a lower spectral density of the frequency component related to myogenic activity compared to controls. Therefore, hypertension appears to be associated to myogenic impairments, causing changes in microvascular modulation and tissue perfusion. ?????? 2014 IEEE.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
