LA PROTEINA V DEL VIRUS LPMV (LA PIEDAD MICHOACAN MESSICO VIRUS) ANTAGONIZZA LA RISPOSTA DI TIPO I DELL’INTERFERONE LEGANDOSI ALLA PROTEINA STAT2 E PREVENENDONE LA TRASLOCAZIONE.

LPMV is the etiologic agent of “blue eye disease”, a disease endemic in Mexico, which mainly affects piglets and is characterized by meningoencephalitis and respiratory distress. The V protein, expressed by most Paramyxoviruses, evade the type I and type II IFN responses by targeting the signaling pathway. In this study we set out to determine if LPMV-V protein possesses IFN signaling antagonist activity, and to identify which signaling components if any are targeted by LPMV-V protein. We demonstrate that LPMV-V protein antagonizes type I but not type II IFN signaling by inhibiting STAT2. Our results indicate that the last 25 amino acids of LPMV-V protein bind endogenous STAT2