A growing body of data supports the hypothesis that probiotics can exert psychotropic effects. Recently, it has been demonstrated that in mice the probiotic Lactobacillus rhamnosus impacts behavior and produces neuroactive substances such as GABA and serotonin, which act on the brain-gut axis. We tested the effects of L. rhamnosus on behavioural and swimming performance in zebrafish (Danio rerio), a well known model organism in translational neuroscience and behavioural research. Adult zebrafish were treated for 28 days with L. rhamnosus, and parameters were measured weekly. Spontaneous activity of fish was evaluated with a video-tracker software, while maximal swimming performance was individually evaluated in a swimming tunnel. Compared with control fishes, treated animals displayed an increase in growth rate and mean spontaneous swimming speed, as well as a change in the shoaling behavior. On the other end, no effect was observed in the maximal swimming speed in a sprint swimming protocol.
CAN PROBIOTICS MODULATE ZEBRAFISH BEHAVIOUR? / Borrelli, Luca; Fioretti, Alessandro; Leggieri, E.; Dipineto, Ludovico; Agnisola, Claudio. - (2014), pp. 58-59. (Intervento presentato al convegno International Congress on the Biology of Fish tenutosi a Heriot - Watt University, Edinburgh nel 3 - 7 August, 2014).
CAN PROBIOTICS MODULATE ZEBRAFISH BEHAVIOUR?
BORRELLI, LUCA;FIORETTI, ALESSANDRO;DIPINETO, LUDOVICO;AGNISOLA, CLAUDIO
2014
Abstract
A growing body of data supports the hypothesis that probiotics can exert psychotropic effects. Recently, it has been demonstrated that in mice the probiotic Lactobacillus rhamnosus impacts behavior and produces neuroactive substances such as GABA and serotonin, which act on the brain-gut axis. We tested the effects of L. rhamnosus on behavioural and swimming performance in zebrafish (Danio rerio), a well known model organism in translational neuroscience and behavioural research. Adult zebrafish were treated for 28 days with L. rhamnosus, and parameters were measured weekly. Spontaneous activity of fish was evaluated with a video-tracker software, while maximal swimming performance was individually evaluated in a swimming tunnel. Compared with control fishes, treated animals displayed an increase in growth rate and mean spontaneous swimming speed, as well as a change in the shoaling behavior. On the other end, no effect was observed in the maximal swimming speed in a sprint swimming protocol.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
