Constitutive activation of NF-κB occurs in a significant percentage of human cancers, including melanoma. Aberrant NF-κB activation sustains cancer survival, contributes to tumor invasion and accounts for therapy resistance. Several studies support a role for FKBP51 in NF-κB activation, however, mechanisms by which FKBP51 controls NF- κB pathway are still not known. FKBP51 has been previously found to interact with IKKα. We studied FKBP51 interactions with a wide number of-κB proteins
FKBP51 sustains the constitutive NF-κB activation in melanoma / Romano, Simona; Sun, Shao Cong; D'Angelillo, Anna; D'Arrigo, Paolo; Bisogni, Rita; Romano, MARIA FIAMMETTA. - In: ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH PROCEEDINGS. - ISSN 0197-016X. - 74:19 supplement(2014), pp. 482-482. [10.1158/1538-7445.AM2014-482]
FKBP51 sustains the constitutive NF-κB activation in melanoma
ROMANO, SIMONA;D'ANGELILLO, ANNA;BISOGNI, RITA;ROMANO, MARIA FIAMMETTA
2014
Abstract
Constitutive activation of NF-κB occurs in a significant percentage of human cancers, including melanoma. Aberrant NF-κB activation sustains cancer survival, contributes to tumor invasion and accounts for therapy resistance. Several studies support a role for FKBP51 in NF-κB activation, however, mechanisms by which FKBP51 controls NF- κB pathway are still not known. FKBP51 has been previously found to interact with IKKα. We studied FKBP51 interactions with a wide number of-κB proteinsI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
