Solids in continuous flow reactors for specialty and pharmaceutical syntheses

Synthetic chemistry is performed almost exclusively in solution phase, with very few solid-phase or gas–solid reactions. However, the limits of solubility of the final products, which are frequently large molecules, as well as the desire to produce the final product in solid form necessitates the issue of handling solids. This is a specific issue for continuous flow reactor technology that has seen rapid development of novel approaches as well as of the fundamental understanding of the underpinning physics. This chapter provides an overview on the topic and links the developed tools with greenness of the continuous flow syntheses.