An experimental procedure for measuring the drug absorbed by a biological tissue in laboratory emulation of dermatological topical treatments is proposed. Laboratory emulation is based on the analysis of the eggplant electrical reaction to the injection of drug. Eggplant and human tissue are both well modeled by a distributed circuit model described by the ColeCole empirical equation. An exploratory measurement campaign aimed at investigating the relationship between the injected drug amount and the measured impedance is reported. The basic ideas, the measurement system design, and the proposed measurement procedure are illustrated. Then, its feasibility is proved experimentally and the results of the metrological characterization are reported and discussed. Results point out that, by a simple measurement of the impedance module (and not a spectroscopy), the amount of injected drug can be assessed by acceptable uncertainty.
Measuring the drug absorbed by biological tissues in laboratory emulation of dermatological topical treatments / Arpaia, P.; Cesaro, U.; Moccaldi, N.. - (2016), pp. 1-5. (Intervento presentato al convegno 11th IEEE International Symposium on Medical Measurements and Applications, MeMeA 2016 tenutosi a University of Sannio, ita nel 2016) [10.1109/MeMeA.2016.7533794].
Measuring the drug absorbed by biological tissues in laboratory emulation of dermatological topical treatments
Arpaia P.;Cesaro U.;Moccaldi N.
2016
Abstract
An experimental procedure for measuring the drug absorbed by a biological tissue in laboratory emulation of dermatological topical treatments is proposed. Laboratory emulation is based on the analysis of the eggplant electrical reaction to the injection of drug. Eggplant and human tissue are both well modeled by a distributed circuit model described by the ColeCole empirical equation. An exploratory measurement campaign aimed at investigating the relationship between the injected drug amount and the measured impedance is reported. The basic ideas, the measurement system design, and the proposed measurement procedure are illustrated. Then, its feasibility is proved experimentally and the results of the metrological characterization are reported and discussed. Results point out that, by a simple measurement of the impedance module (and not a spectroscopy), the amount of injected drug can be assessed by acceptable uncertainty.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
