: The guanine base in nucleic acids is, among the other bases, the most susceptible to being converted into 8-Oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) when exposed to reactive oxygen species. In double-helix DNA, 8-oxodG can pair with adenine; hence, it may cause a G > T (C > A) mutation; it is frequently referred to as a form of DNA damage and promptly corrected by DNA repair mechanisms. Moreover, 8-oxodG has recently been redefined as an epigenetic factor that impacts transcriptional regulatory elements and other epigenetic modifications. It has been proposed that 8-oxodG exerts epigenetic control through interplay with the G-quadruplex (G4), a non-canonical DNA structure, in transcription regulatory regions. In this review, we focused on the epigenetic roles of 8-oxodG and the G4 and explored their interplay at the genomic level.

The Intertwined Role of 8-oxodG and G4 in Transcription Regulation / Gorini, Francesca; Ambrosio, Susanna; Lania, Luigi; Majello, Barbara; Amente, Stefano. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1422-0067. - 24:3(2023), p. 2031. [10.3390/ijms24032031]

The Intertwined Role of 8-oxodG and G4 in Transcription Regulation

Francesca Gorini
Primo
Writing – Original Draft Preparation
;
Susanna Ambrosio
Secondo
Writing – Review & Editing
;
Luigi Lania;Barbara Majello;Stefano Amente
Ultimo
Conceptualization
2023

Abstract

: The guanine base in nucleic acids is, among the other bases, the most susceptible to being converted into 8-Oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) when exposed to reactive oxygen species. In double-helix DNA, 8-oxodG can pair with adenine; hence, it may cause a G > T (C > A) mutation; it is frequently referred to as a form of DNA damage and promptly corrected by DNA repair mechanisms. Moreover, 8-oxodG has recently been redefined as an epigenetic factor that impacts transcriptional regulatory elements and other epigenetic modifications. It has been proposed that 8-oxodG exerts epigenetic control through interplay with the G-quadruplex (G4), a non-canonical DNA structure, in transcription regulatory regions. In this review, we focused on the epigenetic roles of 8-oxodG and the G4 and explored their interplay at the genomic level.
2023
The Intertwined Role of 8-oxodG and G4 in Transcription Regulation / Gorini, Francesca; Ambrosio, Susanna; Lania, Luigi; Majello, Barbara; Amente, Stefano. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1422-0067. - 24:3(2023), p. 2031. [10.3390/ijms24032031]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/920034
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