Cholinergic signaling takes place at synapses to mediate neurotransmission in animals, but is also implicated in different cell-to-cell communication mechanisms that operate in non-neuronal tissues and play important roles for the maintenance of physiological homeostasis. In humans, acetylcholine is involved in the regulation of immune functions, but information about its immunomodulatory potential in invertebrates is still limited. Since neonicotinoids, neurotoxic insecticides that are able to target insect nicotinic acetylcholine receptors (nAChRs), impair the immune response in both Apis mellifera and Drosophila melanogaster, we decided to investigate the role of acetylcholine signaling in insect defense against pathogens. By using a Gal4-UAS expression system, we altered nAChR function in Drosophila immune tissues and tested if and how these manipulations affected fly survival to systemic infection. The obtained results support the occurrence of acetylcholine-based immune regulation in Drosophila, whose impact may differ depending on the species of invading bacteria.
Investigating the role of cholinergic signaling in Drosophila melanogaster defense against bacterial pathogens / DI LELIO, Ilaria; Becchimanzi, Andrea; DE LEVA, Giovanna; Giordani, Giorgia; Cattabriga, Giulia; Cavaliere, Valeria; Gargiulo, Giuseppe; Pennacchio, Francesco; Gigliotti, Silvia. - (2023). (Intervento presentato al convegno XXVII Congresso Nazionale Italiano di Entomologia 2023).
Investigating the role of cholinergic signaling in Drosophila melanogaster defense against bacterial pathogens
Ilaria Di Lelio;Andrea Becchimanzi;Giovanna De Leva;Valeria Cavaliere;Giuseppe Gargiulo;Francesco Pennacchio;Silvia Gigliotti
2023
Abstract
Cholinergic signaling takes place at synapses to mediate neurotransmission in animals, but is also implicated in different cell-to-cell communication mechanisms that operate in non-neuronal tissues and play important roles for the maintenance of physiological homeostasis. In humans, acetylcholine is involved in the regulation of immune functions, but information about its immunomodulatory potential in invertebrates is still limited. Since neonicotinoids, neurotoxic insecticides that are able to target insect nicotinic acetylcholine receptors (nAChRs), impair the immune response in both Apis mellifera and Drosophila melanogaster, we decided to investigate the role of acetylcholine signaling in insect defense against pathogens. By using a Gal4-UAS expression system, we altered nAChR function in Drosophila immune tissues and tested if and how these manipulations affected fly survival to systemic infection. The obtained results support the occurrence of acetylcholine-based immune regulation in Drosophila, whose impact may differ depending on the species of invading bacteria.File | Dimensione | Formato | |
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