: The molecular mechanisms underlying SARS-CoV-2 host cell invasion and life cycle have been studied extensively in recent years, with a primary focus on viral entry and internalization with the aim of identifying antiviral therapies. By contrast, our understanding of the molecular mechanisms involved in the later steps of the coronavirus life cycle is relatively limited. In this review, we describe what is known about the host factors and viral proteins involved in the replication, assembly, and egress phases of SARS-CoV-2, which induce significant host membrane rearrangements. We also discuss the limits of the current approaches and the knowledge gaps still to be addressed.
Membrane remodeling and trafficking piloted by SARS-CoV-2 / Sergio, M. C.; Ricciardi, S.; Guarino, A. M.; Giaquinto, L.; De Matteis, M. A.. - In: TRENDS IN CELL BIOLOGY. - ISSN 0962-8924. - (2024). [10.1016/j.tcb.2023.12.006]
Membrane remodeling and trafficking piloted by SARS-CoV-2
Sergio M. C.Writing – Original Draft Preparation
;Ricciardi S.Writing – Original Draft Preparation
;Guarino A. M.Writing – Original Draft Preparation
;Giaquinto L.Writing – Original Draft Preparation
;De Matteis M. A.
2024
Abstract
: The molecular mechanisms underlying SARS-CoV-2 host cell invasion and life cycle have been studied extensively in recent years, with a primary focus on viral entry and internalization with the aim of identifying antiviral therapies. By contrast, our understanding of the molecular mechanisms involved in the later steps of the coronavirus life cycle is relatively limited. In this review, we describe what is known about the host factors and viral proteins involved in the replication, assembly, and egress phases of SARS-CoV-2, which induce significant host membrane rearrangements. We also discuss the limits of the current approaches and the knowledge gaps still to be addressed.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
