Nanoparticles offered unique properties respect to their bulk counterpart that make them promising vehicles for diagnosis and therapy in cancer. However, only the 0.7 % of administered NPs effectively reach the tumour site. This limited efficacy is mainly due to filtration exerted on NPs by the biological barriers, encountered in their in vivo journey. To improve these nano-bio interactions, we present an optima design of hybrid nanovector, Lipid-Polymer NPs, through an innovative microfluidic process defined as coupled Hydrodynamic Flow Focusing (cHFF). We co-entrapped in the NPs, Gd-DTPA and Atto 633 for MRI and optical imaging, while the Gd-DTPA and Irinotecan for theranostics.
coupled Hydrodynamic Flow Focusing to design Lipid-Polymer NPs (LiPoNs) for theranostics / Roffo, F.; Ponsiglione, A. M.; Netti, P. A.; Torino, E.. - (2023). (Intervento presentato al convegno 8th National Congress of Bioengineering, GNB 2023 tenutosi a ita nel 2023).
coupled Hydrodynamic Flow Focusing to design Lipid-Polymer NPs (LiPoNs) for theranostics
Roffo F.;Ponsiglione A. M.;Netti P. A.;Torino E.
2023
Abstract
Nanoparticles offered unique properties respect to their bulk counterpart that make them promising vehicles for diagnosis and therapy in cancer. However, only the 0.7 % of administered NPs effectively reach the tumour site. This limited efficacy is mainly due to filtration exerted on NPs by the biological barriers, encountered in their in vivo journey. To improve these nano-bio interactions, we present an optima design of hybrid nanovector, Lipid-Polymer NPs, through an innovative microfluidic process defined as coupled Hydrodynamic Flow Focusing (cHFF). We co-entrapped in the NPs, Gd-DTPA and Atto 633 for MRI and optical imaging, while the Gd-DTPA and Irinotecan for theranostics.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
