IRIS
PERSICO, MARCO
 Distribuzione geografica
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Continente #
NA - Nord America 2.038
EU - Europa 1.450
AS - Asia 992
AF - Africa 30
SA - Sud America 7
OC - Oceania 2
Continente sconosciuto - Info sul continente non disponibili 1
Totale 4.520
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Nazione #
US - Stati Uniti d'America 1.982
IT - Italia 899
SG - Singapore 338
CN - Cina 330
HK - Hong Kong 233
IE - Irlanda 112
FI - Finlandia 98
NL - Olanda 72
SE - Svezia 69
CA - Canada 55
RU - Federazione Russa 52
DE - Germania 51
UA - Ucraina 49
VN - Vietnam 47
GB - Regno Unito 27
CI - Costa d'Avorio 25
IN - India 18
FR - Francia 12
JP - Giappone 9
BR - Brasile 5
CY - Cipro 5
ID - Indonesia 3
TR - Turchia 3
CH - Svizzera 2
KR - Corea 2
PK - Pakistan 2
TH - Thailandia 2
ZA - Sudafrica 2
AU - Australia 1
BA - Bosnia-Erzegovina 1
CL - Cile 1
DK - Danimarca 1
EC - Ecuador 1
EG - Egitto 1
EU - Europa 1
KE - Kenya 1
MD - Moldavia 1
MX - Messico 1
NG - Nigeria 1
NZ - Nuova Zelanda 1
PL - Polonia 1
RO - Romania 1
RS - Serbia 1
SI - Slovenia 1
Totale 4.520
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Città #
Chandler 412
Singapore 269
Hong Kong 233
Napoli 194
Santa Clara 175
Ashburn 123
Millbury 106
Naples 105
Princeton 85
Nanjing 79
Rome 69
Amsterdam 63
Beijing 62
Jacksonville 59
Boston 51
Ottawa 48
Dong Ket 47
Des Moines 38
Dearborn 33
Ann Arbor 27
Nanchang 25
Shenyang 21
Wilmington 21
Lawrence 20
Hebei 19
Boardman 18
Seattle 16
Helsinki 15
Norwalk 15
Vietri Sul Mare 15
Los Angeles 14
Milan 14
Piombino 14
Washington 14
Kronberg 12
Pozzuoli 12
Falls Church 11
Jiaxing 10
Menlo Park 10
Metaponto 10
Tianjin 10
Changsha 9
Woodbridge 9
Mugnano di Napoli 8
Pune 8
Redwood City 8
Dublin 7
Falkenstein 7
Guangzhou 7
Houston 7
Moscow 7
Salerno 7
Cagliari 6
Fairfield 6
Kunming 6
Maletto 6
Oristano 6
Tokyo 6
Vancouver 6
Barano d'Ischia 5
Castenaso 5
Konstanz 5
Limassol 5
Palermo 5
Pescara 5
Capaccio 4
Caserta 4
Cava De' Tirreni 4
Fisciano 4
Hangzhou 4
Indiana 4
Kolkata 4
La Terrasse 4
Mountain View 4
Paris 4
Romano Di Lombardia 4
Battipaglia 3
Campodarsego 3
Centrale 3
Cercola 3
Cesa 3
Chieti 3
Edinburgh 3
Eindhoven 3
Formia 3
Lequile 3
Makassar 3
New York 3
Roccarainola 3
Shanghai 3
Acerra 2
Atella 2
Bari 2
Capodrise 2
Caposele 2
Carlentini 2
Casalnuovo Di Napoli 2
Changchun 2
Chengdu 2
Cosenza 2
Totale 2.856
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Nome #
New antimalarial 3-methoxy-1,2-dioxanes: optimization of cellular pharmacokinetic and pharmacodynamic properties by incorporation of amino and N-heterocyclic moieties at C4. 98
Synthesis, structural behaviors and biological properties of thrombin binding aptamers singly modified with chiral m-nitro-benzene glycidoyl moiety 94
Exploring the photodynamic properties of two antiproliferative benzodiazopyrrole derivatives 80
null 76
Outstanding effects on antithrombin activity of modified TBA diastereomers containing an optically pure acyclic nucleotide analogue 75
Marine inspired antiplasmodial thiazinoquinones: synthesis, computational studies and electrochemical assays 72
Exploring the antimalarial potential of the methoxy-​thiazinoquinone scaffold: Identification of a new lead candidate 72
Benzodiazepine Scaffold as Drug-like Molecular Simplification of FR235222: A Chemical Tool for Exploring HDAC Inhibition 71
ANTIMALARIAL POTENTIAL OF SYNTHETIC QUINONE DERIVATIVES DESIGNED ON THE MODEL OF THE APLIDINONES, NATURAL MARINE THIAZINOQUINONES 71
Antiplasmodial activity of p-substituted benzyl thiazinoquinone derivatives and their potential against parasitic infections 71
Development of Molecular Probes for the Identification of Extra Interaction Sites in the Mid-Gorge and Peripheral Sites of Butyrylcholinesterase (BuChE). Rational Design of Novel, Selective, and Highly Potent BuChE Inhibitors 65
Investigating the role of T7 and T12 residues on biological properties of Thrombin Binding Aptamer: enhancement of anticoagulant activity by a single nucleobase modification 65
Specific Targeting Highly Conserved Residues in the HIV-1 Reverse Transcriptase Primer Grip Region. Design, Synthesis, and Biological Evaluation of Novel, Potent, and Broad Spectrum NNRTIs with Antiviral Activity 64
Cationic porphyrins are tunable gatekeepers of the 20S proteasome 63
Development of piperazine-tethered heterodimers as potent antimalarials against chloroquine-resistant P. falciparum strains. Synthesis and molecular modeling 62
Synthesis, biological evaluation, and electrochemical studies of antiplasmodial thiazinoquinones inspired by marine natural products 62
Investigating the Role of T7 and T12 Residues on the Biological Properties of Thrombin-Binding Aptamer 62
Investigating the Neuroprotective Effects of Turmeric Extract: Structural Interactions of β-Amyloid Peptide with Single Curcuminoids 61
Investigating the antiparasitic potential of the marine sesquiterpene avarone, its reduced form avarol, and the novel semisynthetic thiazinoquinone analogue thiazoavarone 59
Hybrids between H2S-donors and betamethasone 17-valerate or triamcinolone acetonide inhibit mast cell degranulation and promote hyperpolarization of bronchial smooth muscle cells 59
Taxol: a Great Peptido Mimetic Produced byNature 57
Identification of new multi-stage thiazinoquinone compounds with activity against Schistosoma mansoni 56
Insight into the mechanism of action of marine cytotoxic thiazinoquinones 54
Fighting Multiparasitism, a Neglected Reality in Marginalised Community: New Tools from the Sea 54
3D-Structure Activity Relationships of New Simple Antimalarial Endoperoxides 52
Porphyrins, sometimes bolt and sometimes bump key of proteasome 50
3D-Structure Activity Relationships of New Simple Antimalarial Endoperoxides 49
The interaction of heme with plakortin and a synthetic endoperoxide analogue: new insights into the heme-activated antimalarial mechanism 49
A multidisciplinary approach to study the carboxyl-terminal portion of the excitatory amino acid transporter EAAT2:implications for the design of new neuroprotective agents. 48
Synthesis, Anticancer Activity and Computational SAR Analysis of Acylsulfonylpiperazines Derivatives 48
Design, Synthesis and Structure-Activity Relationship Studies of 4-Quinolinyl- and 9-Acrydinylhydrazones as Potent Antimalarial Agents 47
Clotrimazole Scaffold as an Innovative Pharmacophore Towards Potent Antimalarial Agents: Design, Synthesis, and Biological and Structure–Activity Relationship Studies 47
Antimalarial Endoperoxides Inspired by Plakortin 47
From Protein Communication to Drug Discovery 47
Thiazinoquinones as New Promising Multistage Schistosomicidal Compounds Impacting Schistosoma mansoni and Egg Viability 46
Paclitaxel Directly Binds to Bcl-2 and Functionally Mimics Activity of Nur77. 46
Use of Integrated Computational Approaches in the Search for New Therapeutic Agents 46
Specific Targeting of Hepatitis C Virus NS3 RNA Helicase. Discovery of the Potent and Selective Competitive Nucleotide-Mimicking Inhibitor QU663 45
A multidisciplinary approach for the investigation of the antimalarial activity of natural endoperoxides 45
A DFT Study on the Antimalarial Endoperoxides Mechanism of Action. Implications for the Design of New Antimalarial Agents 45
Electrostatic Map of Proteasome α-Rings Encodes the Design of Allosteric Porphyrin-Based Inhibitors Able to Affect 20S Conformation by Cooperative Binding 45
Antimalarial endoperoxides inspired by plakortin 44
Development of novel and potent atypical antipsychotic agents: from rational design to drug candidates 44
New Anticancer Agents Mimicking Protein Recognition Motifs. 43
GTP is an allosteric modulator of the interaction between the guanylate-binding protein 1 and the prosurvival kinase PIM1 43
Oxidative stress-mediated antimalarial activity of plakortin, a natural endoperoxide from the tropical sponge Plakortissimplex 43
Computer-Aided Drug Discovery from Marine Compounds: Identification of the Three-Dimensional Structural Features Responsible for Antimalarial Activity 43
New Insights into the Structure-Activity Relationship and Neuroprotective Profile of Benzodiazepinone Derivatives of Neurounina-1 as Modulators of the Na+/Ca2+Exchanger Isoforms 43
Discovery of Bishomo(hetero)arylpiperazines as Novel Multifunctional Ligands Targeting Dopamine D3 and Serotonin 5-HT1A and 5-HT2A Receptors. 42
Identification of the first inhibitor of the GBP1:PIM1 interaction. Implications for the development of a new class of anticancer agents against paclitaxel resistant cancer cells. 42
Cancer Chemoprevention and Dietary Polyphenols 42
The paradox of Bcl-2: How does paclitaxel convert Bcl-2 function from antiapoptotic to proapoptotic? 42
Manadoperoxides A-D from the Indonesian Sponge Plakortis cfr. simplex. Further insights on the structure-activity relationships of simple 1,2-dioxane antimalarials 41
A multidisciplinary approach for the investigation of the antimalarial activity of natural endoperoxides 41
Editorial (Thematic Issue: Protein Interfaces as Targets in Drug Discovery) 41
Cis-trans photodynamics of benzodiazopyrrole derivatives in view of biomedical applications 40
Design and Synthesis of Potent Antimalarial Agents Based on Clotrimazole Scaffold: Exploring an Innovative Pharmacophore. 40
DESIGN AND SYNTHESIS OF NOVEL ANTIMALARIAL AGENTSBASED ON A POLYAROMATIC SCAFFOLD 40
DESIGN, SYNTHESIS, AND IN VITRO BIOLOGICAL EVALUATIONOF 7-CHLORO-4-QUINOLYLHYDRAZONES AS PROMISING ANTIMALARIALAGENTS 40
Structural and biological studies on new TBA analogues: the role of TBA-quadruplex molecularity in the TBA-thrombin complex 40
A DFT Study on the Antimalarial Endoperoxides Mechanism of Action. Implications for the Design of New Antimalarial Agents 40
Antimalarial 1,2-dioxanes inspired by marine natural products. 40
HYBRIDS BETWEEN H2S-DONORS AND BETAMETHASONE 17-VALERATE OR TRIAMCINOLONE ACETONIDE: IN VITRO EFFECT IN ASTHMA TREATMENT 40
Endoperoxide Derivatives from Marine Organisms: 1,2-Dioxanes of the Plakortin Family as Novel Antimalarial Agents. 39
Antimalarials based on the dioxane scaffold of plakortin. A concise synthesis and SAR studies 39
Covalent Inhibitors of Plasmodium falciparum Glyceraldehyde 3-Phosphate Dehydrogenase with Antimalarial Activity in Vitro 39
Synthesis of N1-arylidene-N2-quinolyl- and N2-acrydinylhydrazones as potent antimalarial agents active against CQ-resistant P. falciparum strains 38
null 38
A multidisciplinary approach disclosing unexplored Aflatoxin B1 roles in severe impairment of vitamin D mechanisms of action 36
Preparation of 4-aminoquinoline derivatives as antimalaria drugs. 36
Antimalarial Potential Of Synthetic Thiazinoquinones 35
Silybins are stereospecific regulators of the 20S proteasome 35
Cooperative binding of the cationic porphyrin tris-t4 enhances catalytic activity of 20s proteasome unveiling a complex distribution of functional states 35
Elucidation of the action mechanism of new antimalarial endoperoxides: a dft investigation to support drug design. 3D-Structure Activity Relationships of new simple antimalarial endoperoxides. 34
Insight into the mechanism of the antimalarial action of plakortins, simple 1,2-dioxane antimalarials 33
Investigation of the Bcl-2 multimerisation process: Structural and functional implications. 33
Derivati 1,2-diossanici di origine marina ad attività antimalarica 33
Abstract C231: A great mime produced by nature: The case of paclitaxel 33
Exploiting Protein Fluctuations at the Active-Site Gorge of Human Cholinesterases: Further Optimization of the Design Strategy to Develop Extremely Potent Inhibitors. 32
The thiazinoquinone scaffold as chemical starting point for the design and synthesis of antiparasitic drugs 32
Specific targeting of peripheral serotonin 5-HT(3) receptors. Synthesis, biological investigation, and structure-activity relationships. 31
Investigating the Antimalarial Potential of Plakortin, a Marine Endoperoxide 31
Marine endoperoxides as antiprotozoan lead compounds 31
Design and synthesis of simple antimalarial endoperoxides. Toward the development of an innovative 3D pharmacophoric model 31
Investigation of a novel pharmacophore for the development ofinnovative antimalarial agents. 31
Derivati 1,2-diossanici di origine marina ad attività antimalarica 30
Tetrasubstituted Pyrrole Derivative Mimetics of Protein–Protein Interaction Hot-Spot Residues: A Promising Class of Anticancer Agents Targeting Melanoma Cells 29
Oxime amides as a novel zinc binding group in histone deacetylase inhibitors: synthesis, biological activity, and computational evaluation 29
Combining 4-Aminoquinoline- and Clotrimazole-Based Pharmacophores toward Innovative and Potent Hybrid Antimalarials. 29
Exploiting extra-interaction sites in the mid-gorge and peripheral site of cholinesterase: rational design of novel, selective, and highly potent inhibitors 29
Development of covalent inhibitors of Plasmodium falciparum glyceraldehyde-3-phosphate dehydrogenase with antiparasitic activity in vitro 29
Progettazione di nuovi agenti anti infettivi per il trattamento della malaria e delle infezioni causate dal virus dell' hiv e dell' hcv 28
Endoperoxide polyketides from a Chinese Plakortis simplex: further evidence of the impact of stereochemistry on antimalarial activity of simple 1,2-dioxanes. 28
Discovery of a spirocyclic 3-bromo-4,5-dihydroisoxazole covalent inhibitor of hGAPDH with antiproliferative activity against pancreatic cancer cells 27
Investigating the Antimalarial Potential of Plakortin, a Marine Endoperoxide 26
Design and synthesis of simple antimalarial endoperoxides. Toward the development of an innovative 3D pharmacophoric model 26
Modulation of the 20S Proteasome Activity by Porphyrin Derivatives Is Steered through Their Charge Distribution 25
Exploiting protein fluctuation at human cholinesterase active-sites. New Perspectives 25
Design and synthesis of simple antimalarial endoperoxides. Toward the development of an innovative 3D pharmacophoric model 24
Innovative approaches for the treatment of malaria: design and synthesis of potent antimalarials based on clotrimazole scaffold. 24
Totale 4.502
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Categoria #
all - tutte 19.475
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 19.475
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/2020202 0 0 0 0 0 0 22 24 16 37 70 33
2020/2021424 21 10 38 26 28 76 26 14 59 11 67 48
2021/2022768 14 4 3 36 10 26 4 81 107 75 153 255
2022/2023927 113 71 17 90 110 121 18 109 141 72 59 6
2023/2024580 25 70 64 61 43 67 21 54 9 22 94 50
2024/2025996 147 196 12 28 81 201 331 0 0 0 0 0
Totale 4.774