A series of 1-acyl-4-sulfonylpiperazine derivatives has been prepared. The antiproliferative effect of these compounds was evaluated in vitro against human prostate cancer cell line C4-2, several among them exhibited interesting growth inhibitory against this particular cell line. Finally, a molecular modeling study was employed to analyze the structure/activity relationships (SAR) of these novel compounds
Synthesis, Anticancer Activity and Computational SAR Analysis of Acylsulfonylpiperazines Derivatives / Benfodda, Zohra; Fritz, Vanessa; Henriquet, Corinne; Fattorusso, Caterina; Torrejon, Gerardo Cebrian; Persico, Marco; Dato, Antonio Di; Menna, Marialuisa; Blancou, Hubert; Fajas, Lluis. - In: MEDICINAL CHEMISTRY. - ISSN 2161-0444. - 07:09(2017), pp. 257-267. [10.4172/2161-0444.1000466]
Synthesis, Anticancer Activity and Computational SAR Analysis of Acylsulfonylpiperazines Derivatives
Fattorusso, Caterina;Persico, Marco;Dato, Antonio Di;Menna, Marialuisa;
2017
Abstract
A series of 1-acyl-4-sulfonylpiperazine derivatives has been prepared. The antiproliferative effect of these compounds was evaluated in vitro against human prostate cancer cell line C4-2, several among them exhibited interesting growth inhibitory against this particular cell line. Finally, a molecular modeling study was employed to analyze the structure/activity relationships (SAR) of these novel compoundsI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
