IRIS
LIMONGELLI, VITTORIO
 Distribuzione geografica
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Continente #
NA - Nord America 1.327
EU - Europa 823
AS - Asia 490
AF - Africa 23
Continente sconosciuto - Info sul continente non disponibili 3
SA - Sud America 2
Totale 2.668
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Nazione #
US - Stati Uniti d'America 1.283
IT - Italia 484
SG - Singapore 239
CN - Cina 200
NL - Olanda 70
IE - Irlanda 66
FI - Finlandia 53
CA - Canada 40
SE - Svezia 40
DE - Germania 27
UA - Ucraina 26
GB - Regno Unito 24
CI - Costa d'Avorio 22
IN - India 16
VN - Vietnam 12
CH - Svizzera 7
JP - Giappone 7
FR - Francia 5
HK - Hong Kong 5
ES - Italia 4
KR - Corea 4
MX - Messico 4
CZ - Repubblica Ceca 3
AR - Argentina 2
BE - Belgio 2
EU - Europa 2
IR - Iran 2
MT - Malta 2
PL - Polonia 2
TR - Turchia 2
A1 - Anonimo 1
AL - Albania 1
BY - Bielorussia 1
DK - Danimarca 1
EG - Egitto 1
IL - Israele 1
LT - Lituania 1
PK - Pakistan 1
RS - Serbia 1
RU - Federazione Russa 1
SI - Slovenia 1
SK - Slovacchia (Repubblica Slovacca) 1
TH - Thailandia 1
Totale 2.668
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Città #
Chandler 230
Singapore 185
Naples 105
Millbury 98
Napoli 83
Ashburn 69
Amsterdam 66
Princeton 60
Nanjing 58
Santa Clara 48
Des Moines 43
Beijing 39
Ottawa 38
Jacksonville 37
Boston 33
Wilmington 27
Lawrence 26
Seattle 22
Nanchang 16
Pune 15
Dong Ket 12
Hebei 12
Torre Annunziata 12
Woodbridge 12
Shenyang 11
Angri 10
Tianjin 10
Rome 9
Jiaxing 8
Houston 7
Milan 7
Sagrado 7
Salerno 7
Boardman 6
Changsha 6
Dublin 6
Formia 6
Kronberg 5
Augusta 4
Bologna 4
Fairfield 4
Falls Church 4
Frattamaggiore 4
Helsinki 4
Ikari 4
Kunming 4
Los Angeles 4
Norwalk 4
Perugia 4
Redwood City 4
Regensburg 4
San Mateo 4
Brescia 3
Caserta 3
Castellammare Di Stabia 3
Florence 3
Langhirano 3
Varedo 3
Bacoli 2
Brugherio 2
Brussels 2
Caltanissetta 2
Council Bluffs 2
Cuauhtémoc 2
Córdoba 2
Darmstadt 2
Edinburgh 2
Guangzhou 2
Hong Kong 2
Imsida 2
Lanzhou 2
Madrid 2
Miami 2
Monza 2
Moscow 2
Mugnano Di Napoli 2
Mugnano di Napoli 2
Niscemi 2
Phoenix 2
Poggiomarino 2
Redmond 2
San Francisco 2
Scuola 2
Seregno 2
Sesto Fiorentino 2
Shenzhen 2
Suwon 2
Tijuana 2
Tokyo 2
Trieste 2
Vancouver 2
Warsaw 2
Abbiategrasso 1
Agropoli 1
Altamura 1
Ann Arbor 1
Arzano 1
Atlanta 1
Bad Bellingen 1
Bangkok 1
Totale 1.601
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Nome #
Design, synthesis and pharmacological characterization of novel potent nonsteroidal agonists of the farnesoid X receptor 67
Hyodeoxycholic acid derivatives as liver X receptor α and G-protein-coupled bile acid receptor agonists 66
Novel Isoxazole Derivatives with Potent FXR Agonistic Activity Prevent Acetaminophen-Induced Liver Injury 61
Identification of cysteinyl-leukotriene-receptor 1 antagonists as ligands for the bile acid receptor GPBAR1 60
Modeling of Cdc25B Dual Specifity Protein Phosphatase Inhibitors: Docking of Ligands and Enzymatic Inhibition Mechanism 59
Investigation around the Oxadiazole Core in the Discovery of a New Chemotype of Potent and Selective FXR Antagonists 59
Targeting bile acid receptors: discovery of a potent and selective Farnesoid X receptor agonist as a new lead in the pharmacological approach to liver diseases 58
Discovery of a Potent and Orally Active Dual GPBAR1/CysLT1R Modulator for the Treatment of Metabolic Fatty Liver Disease 58
Discovery of UDCA derivatives as new modulators of bile acid receptors 56
Homology Modeling of NR2B Modulatory Domain of NMDA Receptor and Analysis of Ifenprodil Binding. 52
Synthesis of new isoxazole derivatives as fxr agonists with improved pharmacokinetic properties 52
Discovery of ((1,2,4-oxadiazol-5-yl)pyrrolidin-3-yl)ureidyl derivatives as selective non-steroidal agonists of the G-protein coupled bile acid receptor-1 50
Modification on Ursodeoxycholic Acid (UDCA) Scaffold. Discovery of Bile Acid Derivatives As Selective Agonists of Cell-Surface G-Protein Coupled Bile Acid Receptor 1 (GP-BAR1) 49
Design, synthesis, and biological evaluation of potent dual agonists of nuclear and membrane bile acid receptors 49
Marine and semi-sinthetic hydroxystroids as new scaffolds for pregnane X receptor modulation 48
Introduction of Nonacidic Side Chains on 6-Ethylcholane Scaffolds in the Identification of Potent Bile Acid Receptor Agonists with Improved Pharmacokinetic Properties 48
Calmodulin-Dependent Kinase II Mediates Vascular Smooth Muscle Cell Proliferation and Is Potentiated by Extracellular Signal Regulated Kinase 47
Structural and conformational requisites in DNA quadruplex groove binding: Another piece to the puzzle 47
Design and synthesis of hyodeoxycholic acid derivatives as GPBAR1 receptor modulators useful in the treatment of colon inflammation 47
Structural and conformational requisites in DNA quadruplex groove binding: Another piece to the puzzle 44
GPBAR1 activation by C6-substituted hyodeoxycholane analogues protect against colitis 44
A New DNA Structural Motif: The G-Triplex 43
Ligand binding to telomeric G-quadruplex DNA investigated by funnel-metadynamics simulations 43
Discovery of a Novel Class of Dual GPBAR1 Agonists-RORγt Inverse Agonists for the Treatment of IL-17-Mediated Disorders 41
Computer-Aided Drug Design Unveils the Structural Requisites for Bile Acid Receptors Modulation 40
Discovery of Bile Acid Derivatives as Potent ACE2 Activators by Virtual Screening and Essential Dynamics 40
Acetic Acid Aldose Reductase Inhibitors Bearing a Five-Membered Heterocyclic Core with Potent Topical Activity in a Visual Impairment Rat Model. 39
Binding mechanism of the farnesoid X receptor marine antagonist suvanine reveals a strategy to forestall drug modulation on nuclear receptors. Design, synthesis, and biological evaluation of novel ligands 39
Structure-based drug design targeting the cell membrane receptor GPBAR1: exploiting the bile acid scaffold towards selective agonism 39
Rational Drug Design of New Selective Modulators of GPBAR1 39
Indolylarylsulfones carrying a heterocyclic tail as very potent and broad spectrum HIV-1 non-nucleoside reverse transcriptase inhibitors 38
Discovery of a new class of GPBAR1 modulators 38
The glycan role in the glycopeptide immunogenicity revealed by atomistic simulations and spectroscopic experiments on the multiple sclerosis biomarker CSF114(Glc) 37
Structural Basis for Developing Multitarget Compounds Acting on Cysteinyl Leukotriene Receptor 1 and G-Protein-Coupled Bile Acid Receptor 1 37
Epoxide functionalization on cholane side chains in the identification of G-protein coupled bile acid receptor (GPBAR1) selective agonists 35
Breaking the dogma of the metal-coordinating carboxylate group in integrin ligands: introducing hydroxamic acids to the MIDAS to tune potency and selectivity 33
G-triplex structure and formation propensity 33
Accelerating the Calculation of Protein-Ligand Binding Free Energy and Residence Times Using Dynamically Optimized Collective Variables 33
Expanding the Library of 1,2,4-Oxadiazole Derivatives: Discovery of New Farnesoid X Receptor (FXR) Antagonists/Pregnane X Receptor (PXR) Agonists 32
Ensemble-docking approach on BACE-1: pharmacophore perception and guidelines for drug design 32
Novel N2-substituted pyrazolo[3,4-d]pyrimidine adenosine A3 receptor antagonists: inhibition of A3-mediated human glioblastoma cell proliferation 32
Potent dual agonists of nuclear and membrane bile acid receptors 32
Discovery of amine bile acid derivatives as selective agonists of cell-surface G-protein coupled bile acid receptor 1 32
Disruption of TFGβ-SMAD3 pathway by the nuclear receptor SHP mediates the antifibrotic activities of BAR704, a novel highly selective FXR ligand 32
Bioinformatics and Biosimulations as Toolbox for Peptides and Peptidomimetics Design: Where Are We? 32
Elucidating the Binding Behavior of Highly Potent COX-2 Selective Inhibitors 31
Phosphorylation of FAM134C by CK2 controls starvation-induced ER-phagy 30
Structural Insight into the Binding Mode of FXR and GPBAR1 Modulators 29
Design, Synthesis, and Biological Evaluation of Novel Aminobisphosphonates Possessing an in Vivo Antitumor Activity Through a γδ -T Lymphocytes-Mediated Activation Mechanism. 28
Stop Fitan: Antispasmodic Effect of Natural Extract of Chestnut Wood in Guinea Pig Ileum and Proximal Colon Smooth Muscle 27
Insight on pregnane-X-receptor modulation. Natural and semisynthetic steroids from Theonella marine sponges 27
Dual binding mode of SC-558 in COX-2: A new frontier in COX inhibition 25
Kinetics of protein-ligand unbinding: Predicting pathways, rates, and rate-limiting steps 25
Synthesis of new oxadiazole derivatives as potent and selective FXR antagonists 25
Design, synthesis and biologicalevaluation of carboxy analogues of arginine methyltransferase 24
Binding of the Anti-FIV Peptide C8 to Differently Charged Membrane Models: From First Docking to Membrane Tubulation 24
Design, Synthesis and Biological Evaluation of Carboxy Analogues of Arginine Methyltransferase Inhibitor 1 (AMI-1) 22
The G-triplex DNA 22
Ligand Binding to Telomeric DNA G-quadruplex through Metadynamics Calculations 22
Conformational Changes in the Epidermal Growth Factor Receptor: Role of the Transmembrane Domain Investigated by Coarse-Grained MetaDynamics Free Energy Calculations 21
Dual binding mode of SC-558 in COX-2: A new frontier in COX inhibition 19
Incisterols, highly degraded marine sterols, are a new chemotype of PXR agonists 19
Mechanistic insight into ligand binding to G-quadruplex DNA 19
DDT - Drug Discovery Tool: a fast and intuitive graphics user interface for Docking and Molecular Dynamics analysis 19
Potent Arylsulfonamide Inhibitors of Tumor Necrosis Factor-alfa Converting Enzyme Able to Reduce Activated Leukocyte Cell Adhesion Molecule Shedding in Cancer Cell Models 18
Probing the Charge Capability of the MIDAS: Phosphinic- and Phosphonic Acid Containing Compounds as New Potent allb beta 3 Integrin Antagonists 18
Funnel-metadynamics and solution NMR to estimate protein-ligand affinities 18
Investigating the mechanism of substrate uptake and release in the glutamate transporter homologue Glt(Ph) through metadynamics simulations. 17
Marine and semi-synthetic hydroxysteroids as new scaffolds for pregnane x receptor modulation. 17
Unbinding Kinetics of a p38 MAP Kinase Type II Inhibitor from Metadynamics Simulations 17
Molecular Modeling for Nanomaterial-Biology Interactions: Opportunities, Challenges, and Perspectives 17
Sampling protein motion and solvent effect during ligand binding. 16
Steroidal scaffolds as FXR and GPBAR1 ligands: from chemistry to therapeutical application 16
Energetics and structural characterization of the large-scale functional motion of adenylate kinase 16
Correction to “Discovery of a Novel Class of Dual GPBAR1 Agonists–RORγt Inverse Agonists for the Treatment of IL-17-Mediated Disorders” 15
Ethyl 8-Fluoro-6-(3-nitrophenyl)-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate as Novel, Highly Potent, and Safe Antianxiety Agent. 15
Tailoring of integrin ligands: probing the charge capability of the metal ion-dependent adhesion site. 15
Membrane charge dependent states of the β-amyloid fragment Aβ (16–35) with differently charged micelle aggregates 14
gamma-Glutamyl 16-diaminopropane derivative of vasoactive intestinal peptide: a potent anti-oxidative agent for human epidermoid cancer cells 14
The Free Energy Landscape of GABA Binding to a Pentameric Ligand-Gated Ion Channel and Its Disruption by Mutations 14
Drug Repurposing on G Protein-Coupled Receptors Using a Computational Profiling Approach 13
Membrane charge dependent states of the beta -amyloid fragment A beta (16-35) with differently charged micelle aggregates 13
Transferring chemical and energetic knowledge between molecular systems with machine learning 12
Funnel metadynamics as accurate binding free-energy method 12
Molecular basis of cyclooxygenase enzymes (COXs) selective inhibition 12
New insight into the central benzodiazepine receptor-ligand interactions: design, synthesis, biological evaluation, and molecular modeling of 3-substituted 6-phenyl-4H-imidazo[1,5-a][1,4]benzodiazepines and related compounds 11
The Molecular Mechanism Underlying Ligand Binding to the Membrane-Embedded Site of a G-Protein-Coupled Receptor 10
Ligand Binding, Unbinding, and Allosteric Effects: Deciphering Small-Molecule Modulation of HSP90 10
Ligand binding free-energy calculations with funnel metadynamics 10
Promoting transparency and reproducibility in enhanced molecular simulations 9
Ligand binding free energy and kinetics calculation in 2020 8
Improving Small-Molecule Force Field Parameters in Ligand Binding Studies 7
Perspectives on High-Throughput Ligand/Protein Docking With Martini MD Simulations 7
Protein–ligand binding with the coarse-grained Martini model 7
International Scientific Collaboration Is Needed to Bridge Science to Society: USERN2020 Consensus Statement 7
Totale 2.855
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Categoria #
all - tutte 13.461
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 13.461
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/2020142 0 0 0 0 20 10 4 20 0 22 42 24
2020/2021258 20 8 28 8 37 51 21 14 35 4 16 16
2021/2022449 10 3 1 4 6 15 5 28 68 33 74 202
2022/2023649 91 38 25 42 71 61 11 79 94 73 40 24
2023/2024470 34 62 47 23 23 44 13 57 20 18 91 38
2024/2025362 136 129 24 29 44 0 0 0 0 0 0 0
Totale 2.855