IRIS
Di Leva, Francesco Saverio
 Distribuzione geografica
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Continente #
EU - Europa 1.230
NA - Nord America 1.107
AS - Asia 704
AF - Africa 29
SA - Sud America 14
Continente sconosciuto - Info sul continente non disponibili 1
Totale 3.085
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Nazione #
US - Stati Uniti d'America 1.077
IT - Italia 553
SG - Singapore 305
DE - Germania 291
CN - Cina 188
HK - Hong Kong 156
FI - Finlandia 125
RU - Federazione Russa 67
NL - Olanda 64
IE - Irlanda 34
GB - Regno Unito 31
CA - Canada 28
CI - Costa d'Avorio 28
VN - Vietnam 20
IN - India 16
BR - Brasile 13
UA - Ucraina 11
JP - Giappone 9
SE - Svezia 8
FR - Francia 7
BG - Bulgaria 6
AT - Austria 5
BE - Belgio 5
CH - Svizzera 4
HR - Croazia 4
IR - Iran 4
LT - Lituania 3
ES - Italia 2
IL - Israele 2
KR - Corea 2
MT - Malta 2
RS - Serbia 2
A1 - Anonimo 1
BY - Bielorussia 1
CO - Colombia 1
DK - Danimarca 1
EE - Estonia 1
EG - Egitto 1
GR - Grecia 1
IS - Islanda 1
MX - Messico 1
NO - Norvegia 1
PA - Panama 1
PK - Pakistan 1
TR - Turchia 1
Totale 3.085
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Città #
Singapore 197
Chandler 184
Hong Kong 156
Munich 154
Santa Clara 110
Helsinki 94
Naples 94
Napoli 87
Nanjing 59
Amsterdam 58
Millbury 55
Ashburn 45
Des Moines 43
Princeton 41
Beijing 36
Boston 30
Ottawa 25
Wilmington 23
Dong Ket 20
Lawrence 17
Nürnberg 17
Rome 17
Nanchang 13
Leawood 12
Milan 12
Hebei 11
Pune 11
Seattle 11
Angri 10
Jacksonville 10
Falkenstein 8
Houston 8
Nuremberg 8
Salerno 8
Shenyang 8
Bari 7
Florence 7
Norwalk 7
Parma 7
Tianjin 7
Castellammare Di Stabia 6
Jiaxing 6
Quarto 6
Sofia 6
Woodbridge 6
Amorosi 5
Brussels 5
Changsha 5
Fairfield 5
Jyväskylä 5
Redwood City 5
Shanghai 5
Enfield 4
Frattamaggiore 4
Ikari 4
Mugnano di Napoli 4
Piombino 4
Reggio Emilia 4
Tokyo 4
Zagreb 4
Battipaglia 3
Bologna 3
Cagliari 3
Caserta 3
Darmstadt 3
Dublin 3
Frankfurt am Main 3
Jinan 3
London 3
Los Angeles 3
Orta di Atella 3
Palermo 3
Redmond 3
Rende 3
The Dalles 3
Varedo 3
Vienna 3
Ann Arbor 2
Arzano 2
Augusta 2
Bacoli 2
Boardman 2
Garching 2
Guangzhou 2
Imsida 2
Issiglio 2
Kensington 2
Kunming 2
Montesilvano Marina 2
Monza 2
Moscow 2
Mugnano Di Napoli 2
Ningbo 2
Niscemi 2
Orange 2
Pescara 2
Philadelphia 2
Rho 2
Sagrado 2
San Biagio di Callalta 2
Totale 1.921
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Nome #
Discovery of UDCA derivatives as new modulators of bile acid receptors 183
Potent dual agonists of nuclear and membrane bile acid receptors 161
Pharmacophoric Modifications Lead to Superpotent avb3 Integrin Ligands with Suppressed a5b1 Activity 139
Click-Chemistry (CuAAC) Trimerization of an αvβ6 Integrin Targeting Ga-68-Peptide: Enhanced Contrast for in-Vivo PET Imaging of Human Lung Adenocarcinoma Xenografts 76
Design, synthesis and pharmacological characterization of novel potent nonsteroidal agonists of the farnesoid X receptor 74
Hyodeoxycholic acid derivatives as liver X receptor α and G-protein-coupled bile acid receptor agonists 71
Novel Isoxazole Derivatives with Potent FXR Agonistic Activity Prevent Acetaminophen-Induced Liver Injury 66
Targeting bile acid receptors: discovery of a potent and selective Farnesoid X receptor agonist as a new lead in the pharmacological approach to liver diseases 65
Investigation around the Oxadiazole Core in the Discovery of a New Chemotype of Potent and Selective FXR Antagonists 65
From a Helix to a Small Cycle: Metadynamics-Inspired αvβ6 Integrin Selective Ligands 61
Exploring the N-Terminal Region of C-X-C Motif Chemokine 12 (CXCL12): Identification of Plasma-Stable Cyclic Peptides As Novel, Potent C-X-C Chemokine Receptor Type 4 (CXCR4) Antagonists 58
Marine and semi-sinthetic hydroxystroids as new scaffolds for pregnane X receptor modulation 57
Design, synthesis, and biological evaluation of potent dual agonists of nuclear and membrane bile acid receptors 57
Disulfide bond replacement with 1,4‐ and 1,5‐disubstituted [1,2,3]‐triazole on C‐X‐C chemokine receptor type 4 (CXCR4) peptide ligands: small changes that make big differences 57
Design and synthesis of hyodeoxycholic acid derivatives as GPBAR1 receptor modulators useful in the treatment of colon inflammation 57
Modification on Ursodeoxycholic Acid (UDCA) Scaffold. Discovery of Bile Acid Derivatives As Selective Agonists of Cell-Surface G-Protein Coupled Bile Acid Receptor 1 (GP-BAR1) 56
Discovery of ((1,2,4-oxadiazol-5-yl)pyrrolidin-3-yl)ureidyl derivatives as selective non-steroidal agonists of the G-protein coupled bile acid receptor-1 56
Introduction of Nonacidic Side Chains on 6-Ethylcholane Scaffolds in the Identification of Potent Bile Acid Receptor Agonists with Improved Pharmacokinetic Properties 56
Targeting SARS-CoV-2 Proteases and Polymerase for COVID-19 Treatment: State of the Art and Future Opportunities 55
Targeting the Human Telomeric G-Quadruplex Through Virtual Screening Calculations 53
Computer-Aided Drug Design Unveils the Structural Requisites for Bile Acid Receptors Modulation 53
GPBAR1 activation by C6-substituted hyodeoxycholane analogues protect against colitis 53
Lead Discovery of Dual G-Quadruplex Stabilizers and Poly(ADP-ribose) Polymerases (PARPs) Inhibitors: A New Avenue in Anticancer Treatment 52
Ligand-Based NMR Study of C-X-C Chemokine Receptor Type 4 (CXCR4)-Ligand Interactions on Living Cancer Cells 52
Broad-spectrum coronavirus 3C-like protease peptidomimetic inhibitors effectively block SARS-CoV-2 replication in cells: Design, synthesis, biological evaluation, and X-ray structure determination 51
Halting the Spread of Herpes Simplex Virus-1: The Discovery of an Effective Dual αvβ6/αvβ8 Integrin Ligand 51
Structure-Activity Relationships and Biological Characterization of a Novel, Potent, and Serum Stable C-X-C Chemokine Receptor Type 4 (CXCR4) Antagonist 50
Discovery of 2,3-Diaminoindole Derivatives as a Novel Class of NOD Antagonists 46
State-of-the-art methodologies for the discovery and characterization of DNA G-Quadruplex binders 46
Binding mechanism of the farnesoid X receptor marine antagonist suvanine reveals a strategy to forestall drug modulation on nuclear receptors. Design, synthesis, and biological evaluation of novel ligands 46
Development and Nanoparticle-Mediated Delivery of Novel MDM2/MDM4 Heterodimer Peptide Inhibitors to Enhance 5-Fluorouracil Nucleolar Stress in Colorectal Cancer Cells 45
Structure-based drug design targeting the cell membrane receptor GPBAR1: exploiting the bile acid scaffold towards selective agonism 44
The organometallic ferrocene exhibits amplified anti-tumor activity by targeted delivery via highly selective ligands to αvβ3, αvβ6, or α5β1 integrins 43
Expanding the Library of 1,2,4-Oxadiazole Derivatives: Discovery of New Farnesoid X Receptor (FXR) Antagonists/Pregnane X Receptor (PXR) Agonists 42
Epoxide functionalization on cholane side chains in the identification of G-protein coupled bile acid receptor (GPBAR1) selective agonists 42
Identification of novel molecular scaffolds for the design of MMP-13 inhibitors: A first round of lead optimization. 41
Biselectivity of isoDGR Peptides for Fibronectin Binding Integrin Subtypes α5β1 and αvβ6: Conformational Control through Flanking Amino Acids 41
Basic Quinolinonyl Diketo Acid Derivatives as Inhibitors of HIV Integrase and their Activity against RNase H Function of Reverse Transcriptase 41
Discovery of dihydroxyindole-2-carboxylic acid derivatives as dual allosteric HIV-1 Integrase and Reverse Transcriptase associated Ribonuclease H inhibitors 41
Theoretical and experimental studies on the interaction of biphenyl ligands with human and murine PD-L1: Up-to-date clues for drug design 40
Discovery of amine bile acid derivatives as selective agonists of cell-surface G-protein coupled bile acid receptor 1 39
Elucidating the Binding Behavior of Highly Potent COX-2 Selective Inhibitors 39
Bioinformatics and Biosimulations as Toolbox for Peptides and Peptidomimetics Design: Where Are We? 39
Selective Targeting of Integrin αvβ8 by a Highly Active Cyclic Peptide 37
Targeting the KRAS oncogene: Synthesis, physicochemical and biological evaluation of novel G-Quadruplex DNA binders 37
Exploring the chemical space of G-quadruplex binders: Discovery of a novel chemotype targeting the human telomeric sequence 36
Structural Insight into the Binding Mode of FXR and GPBAR1 Modulators 36
N-Substituted Quinolinonyl Diketo Acid Derivatives as HIV Integrase Strand Transfer Inhibitors and Their Activity against RNase H Function of Reverse Transcriptase 34
Simultaneous Targeting of RGD-Integrins and Dual Murine Double Minute Proteins in Glioblastoma Multiforme 34
The ring residue proline 8 is crucial for the thermal stability of the lasso peptide caulosegnin II 32
Stable Peptides Instead of Stapled Peptides: Highly Potent αvβ6-Selective Integrin Ligands 31
Synthesis of new oxadiazole derivatives as potent and selective FXR antagonists 31
Phenylpyrazolo[1,5-a]quinazolin-5(4H)-one: a suitable scaffold for the development of non-camptothecin Topoisomerase I (Top1) inhibitors. 30
Protein Flexibility in Virtual Screening: The BACE-1 Case Study 29
Monothiocarbamates Strongly Inhibit Carbonic Anhydrases in Vitro and Possess Intraocular Pressure Lowering Activity in an Animal Model of Glaucoma 29
Identification of highly conserved residues involved in inhibition of HIV-1 RNase H function by diketo acid derivatives 29
Discovery of N-aryl-naphthylamines as in vitro inhibitors of the interaction between HIV integrase and the cofactor LEDGF/p75 29
Ligand Binding to Telomeric DNA G-quadruplex through Metadynamics Calculations 28
Overcoming the Lack of Oral Availability of Cyclic Hexapeptides: Design of a Selective and Orally Available Ligand for the Integrin αvβ3 28
N-Methylation of isoDGR Peptides: Discovery of a Selective α5β1-Integrin Ligand as a Potent Tumor Imaging Agent 27
A combined approach of structure‐based virtual screening and NMR to interrupt the PD‐1/PD‐L1 axis: Biphenyl‐benzimidazole containing compounds as novel PD‐L1 inhibitors 26
Rational Improvement of the Affinity and Selectivity of Integrin Binding of Grafted Lasso Peptides 26
Mechanistic insight into ligand binding to G-quadruplex DNA 25
Marine and semi-synthetic hydroxysteroids as new scaffolds for pregnane x receptor modulation. 23
Pharmacological targeting of smoothened receptor cysteine-rich domain by Budesonide promotes in vitro myelination 23
New insights into the interaction between pyrrolyl diketoacids and HIV-1 integrase active site and comparison with RNase H 22
Molecular View on the iRGD Peptide Binding Mechanism: Implications for Integrin Activity and Selectivity Profiles 21
The Inhibition of DNA Viruses by the Amphibian Antimicrobial Peptide Temporin G: A Virological Study Addressing HSV-1 and JPCyV 21
Paper-based electrochemical device for early detection of integrin αvβ6 expressing tumors 18
Exploring the 1,3-benzoxazine chemotype for cannabinoid receptor 2 as a promising anti-cancer therapeutic 18
Totale 3.320
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Categoria #
all - tutte 12.993
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 12.993
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/2020101 0 0 0 0 0 0 0 0 7 30 34 30
2020/2021319 34 11 11 14 45 55 36 17 30 12 25 29
2021/2022343 3 1 3 10 9 15 7 20 36 42 64 133
2022/2023481 61 31 17 27 65 52 0 48 72 59 36 13
2023/2024398 25 61 41 33 14 27 13 51 17 18 63 35
2024/20251.135 110 118 16 54 47 206 327 198 59 0 0 0
Totale 3.320