IRIS
Di Leva, Francesco Saverio
 Distribuzione geografica
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Continente #
AS - Asia 3.072
EU - Europa 2.676
NA - Nord America 2.397
SA - Sud America 369
AF - Africa 88
Continente sconosciuto - Info sul continente non disponibili 2
OC - Oceania 2
Totale 8.606
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Nazione #
US - Stati Uniti d'America 2.316
SG - Singapore 1.327
RU - Federazione Russa 944
IT - Italia 757
CN - Cina 618
VN - Vietnam 588
DE - Germania 392
BR - Brasile 289
HK - Hong Kong 213
FI - Finlandia 158
FR - Francia 113
GB - Regno Unito 80
NL - Olanda 79
JP - Giappone 62
IN - India 56
CA - Canada 43
IE - Irlanda 36
KR - Corea 36
AR - Argentina 35
BD - Bangladesh 29
CI - Costa d'Avorio 29
TR - Turchia 26
IQ - Iraq 25
ZA - Sudafrica 23
UA - Ucraina 19
MX - Messico 18
PH - Filippine 17
SE - Svezia 17
PL - Polonia 15
ID - Indonesia 12
ES - Italia 11
TH - Thailandia 11
EC - Ecuador 10
CO - Colombia 9
PK - Pakistan 9
VE - Venezuela 9
CH - Svizzera 8
PY - Paraguay 8
TW - Taiwan 8
AT - Austria 7
BG - Bulgaria 7
IL - Israele 7
LT - Lituania 6
MA - Marocco 6
PA - Panama 6
BE - Belgio 5
CL - Cile 5
EG - Egitto 5
HR - Croazia 4
IR - Iran 4
JM - Giamaica 4
OM - Oman 4
RS - Serbia 4
TN - Tunisia 4
CZ - Repubblica Ceca 3
DZ - Algeria 3
ET - Etiopia 3
MT - Malta 3
MY - Malesia 3
PR - Porto Rico 3
UZ - Uzbekistan 3
AO - Angola 2
GE - Georgia 2
JO - Giordania 2
KE - Kenya 2
NG - Nigeria 2
NP - Nepal 2
SA - Arabia Saudita 2
SN - Senegal 2
TT - Trinidad e Tobago 2
UY - Uruguay 2
A1 - Anonimo 1
AE - Emirati Arabi Uniti 1
AL - Albania 1
AU - Australia 1
AZ - Azerbaigian 1
BB - Barbados 1
BJ - Benin 1
BN - Brunei Darussalam 1
BO - Bolivia 1
BY - Bielorussia 1
BZ - Belize 1
CG - Congo 1
CR - Costa Rica 1
DK - Danimarca 1
DM - Dominica 1
EE - Estonia 1
GA - Gabon 1
GM - Gambi 1
GP - Guadalupe 1
GR - Grecia 1
GU - Guam 1
IS - Islanda 1
KZ - Kazakistan 1
NE - Niger 1
NO - Norvegia 1
PE - Perù 1
PS - Palestinian Territory 1
PT - Portogallo 1
SL - Sierra Leone 1
Totale 8.603
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Città #
Singapore 624
San Jose 441
Moscow 243
Munich 211
Hong Kong 209
Ashburn 202
Beijing 194
Naples 190
Chandler 184
Ho Chi Minh City 159
Santa Clara 122
Hanoi 120
Hefei 116
Helsinki 101
Dallas 92
Napoli 87
Los Angeles 71
The Dalles 70
Lauterbourg 68
Amsterdam 63
Nanjing 59
Millbury 55
Tokyo 49
Des Moines 45
Boston 43
Princeton 41
Redondo Beach 36
Rome 28
New York 26
Ottawa 25
Haiphong 23
São Paulo 23
Wilmington 23
Dong Ket 20
Da Nang 19
Seoul 19
Buffalo 18
Frankfurt am Main 18
Lawrence 17
Milan 17
Nürnberg 17
Seattle 14
Turku 14
Nanchang 13
Warsaw 13
Atlanta 12
Baghdad 12
Biên Hòa 12
Houston 12
Leawood 12
Nuremberg 12
Ankara 11
Brooklyn 11
Council Bluffs 11
Hebei 11
Pune 11
Angri 10
Chennai 10
Chicago 10
Düsseldorf 10
Falkenstein 10
Hải Dương 10
Jacksonville 10
Manchester 10
Stockholm 10
Bari 9
Johannesburg 9
Kochi 9
Lappeenranta 9
London 9
Orem 9
Rio de Janeiro 9
Shanghai 9
Tianjin 9
Changsha 8
Mexico City 8
Portsmouth 8
Salerno 8
Shenyang 8
Campinas 7
Curitiba 7
Denver 7
Dhaka 7
Florence 7
Istanbul 7
Ninh Bình 7
Norwalk 7
Parma 7
Porto Alegre 7
Quận Ba 7
Bologna 6
Castellammare Di Stabia 6
Jiaxing 6
Jyväskylä 6
Panama City 6
Phoenix 6
Quarto 6
Sofia 6
Tân Tiến 6
Woodbridge 6
Totale 4.717
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Nome #
Discovery of UDCA derivatives as new modulators of bile acid receptors 295
Potent dual agonists of nuclear and membrane bile acid receptors 270
Pharmacophoric Modifications Lead to Superpotent avb3 Integrin Ligands with Suppressed a5b1 Activity 210
Click-Chemistry (CuAAC) Trimerization of an αvβ6 Integrin Targeting Ga-68-Peptide: Enhanced Contrast for in-Vivo PET Imaging of Human Lung Adenocarcinoma Xenografts 180
Design, synthesis and pharmacological characterization of novel potent nonsteroidal agonists of the farnesoid X receptor 174
Discovery of 2,3-Diaminoindole Derivatives as a Novel Class of NOD Antagonists 169
Novel Isoxazole Derivatives with Potent FXR Agonistic Activity Prevent Acetaminophen-Induced Liver Injury 169
Broad-spectrum coronavirus 3C-like protease peptidomimetic inhibitors effectively block SARS-CoV-2 replication in cells: Design, synthesis, biological evaluation, and X-ray structure determination 167
Development and Nanoparticle-Mediated Delivery of Novel MDM2/MDM4 Heterodimer Peptide Inhibitors to Enhance 5-Fluorouracil Nucleolar Stress in Colorectal Cancer Cells 158
Exploring the N-Terminal Region of C-X-C Motif Chemokine 12 (CXCL12): Identification of Plasma-Stable Cyclic Peptides As Novel, Potent C-X-C Chemokine Receptor Type 4 (CXCR4) Antagonists 151
Hyodeoxycholic acid derivatives as liver X receptor α and G-protein-coupled bile acid receptor agonists 151
Marine and semi-sinthetic hydroxystroids as new scaffolds for pregnane X receptor modulation 148
Structure-Activity Relationships and Biological Characterization of a Novel, Potent, and Serum Stable C-X-C Chemokine Receptor Type 4 (CXCR4) Antagonist 147
Targeting the Human Telomeric G-Quadruplex Through Virtual Screening Calculations 144
Paper-based electrochemical device for early detection of integrin αvβ6 expressing tumors 138
Theoretical and experimental studies on the interaction of biphenyl ligands with human and murine PD-L1: Up-to-date clues for drug design 138
State-of-the-art methodologies for the discovery and characterization of DNA G-Quadruplex binders 137
Design and synthesis of hyodeoxycholic acid derivatives as GPBAR1 receptor modulators useful in the treatment of colon inflammation 136
Expanding the Library of 1,2,4-Oxadiazole Derivatives: Discovery of New Farnesoid X Receptor (FXR) Antagonists/Pregnane X Receptor (PXR) Agonists 135
Computer-Aided Drug Design Unveils the Structural Requisites for Bile Acid Receptors Modulation 135
Discovery of ((1,2,4-oxadiazol-5-yl)pyrrolidin-3-yl)ureidyl derivatives as selective non-steroidal agonists of the G-protein coupled bile acid receptor-1 133
Disulfide bond replacement with 1,4‐ and 1,5‐disubstituted [1,2,3]‐triazole on C‐X‐C chemokine receptor type 4 (CXCR4) peptide ligands: small changes that make big differences 133
A combined approach of structure‐based virtual screening and NMR to interrupt the PD‐1/PD‐L1 axis: Biphenyl‐benzimidazole containing compounds as novel PD‐L1 inhibitors 129
Simultaneous Targeting of RGD-Integrins and Dual Murine Double Minute Proteins in Glioblastoma Multiforme 127
Ligand-Based NMR Study of C-X-C Chemokine Receptor Type 4 (CXCR4)-Ligand Interactions on Living Cancer Cells 123
From a Helix to a Small Cycle: Metadynamics-Inspired αvβ6 Integrin Selective Ligands 123
Deepening bis-(thio)carbohydrazones conformational dynamics and hydrogen bond interactions in a non-protic solvent: DFT, molecular dynamics, NMR, and Raman investigations 122
Introduction of Nonacidic Side Chains on 6-Ethylcholane Scaffolds in the Identification of Potent Bile Acid Receptor Agonists with Improved Pharmacokinetic Properties 120
Elucidating the Binding Behavior of Highly Potent COX-2 Selective Inhibitors 118
Modification on Ursodeoxycholic Acid (UDCA) Scaffold. Discovery of Bile Acid Derivatives As Selective Agonists of Cell-Surface G-Protein Coupled Bile Acid Receptor 1 (GP-BAR1) 116
Epoxide functionalization on cholane side chains in the identification of G-protein coupled bile acid receptor (GPBAR1) selective agonists 111
Pharmacological targeting of smoothened receptor cysteine-rich domain by Budesonide promotes in vitro myelination 111
Discovery of N-aryl-naphthylamines as in vitro inhibitors of the interaction between HIV integrase and the cofactor LEDGF/p75 110
Targeting the KRAS oncogene: Synthesis, physicochemical and biological evaluation of novel G-Quadruplex DNA binders 110
Discovery of amine bile acid derivatives as selective agonists of cell-surface G-protein coupled bile acid receptor 1 109
Identification of highly conserved residues involved in inhibition of HIV-1 RNase H function by diketo acid derivatives 109
Investigation around the Oxadiazole Core in the Discovery of a New Chemotype of Potent and Selective FXR Antagonists 109
GPBAR1 activation by C6-substituted hyodeoxycholane analogues protect against colitis 109
Halting the Spread of Herpes Simplex Virus-1: The Discovery of an Effective Dual αvβ6/αvβ8 Integrin Ligand 109
Discovery of dihydroxyindole-2-carboxylic acid derivatives as dual allosteric HIV-1 Integrase and Reverse Transcriptase associated Ribonuclease H inhibitors 108
Ex.50.T aptamer impairs tumor–stroma cross-talk in breast cancer by targeting gremlin-1 106
Biselectivity of isoDGR Peptides for Fibronectin Binding Integrin Subtypes α5β1 and αvβ6: Conformational Control through Flanking Amino Acids 106
Basic Quinolinonyl Diketo Acid Derivatives as Inhibitors of HIV Integrase and their Activity against RNase H Function of Reverse Transcriptase 106
Protein Flexibility in Virtual Screening: The BACE-1 Case Study 105
Design, synthesis, and biological evaluation of potent dual agonists of nuclear and membrane bile acid receptors 105
Identification of novel molecular scaffolds for the design of MMP-13 inhibitors: A first round of lead optimization. 103
Stable Peptides Instead of Stapled Peptides: Highly Potent αvβ6-Selective Integrin Ligands 102
The ring residue proline 8 is crucial for the thermal stability of the lasso peptide caulosegnin II 102
Targeting bile acid receptors: discovery of a potent and selective Farnesoid X receptor agonist as a new lead in the pharmacological approach to liver diseases 102
Targeting SARS-CoV-2 Proteases and Polymerase for COVID-19 Treatment: State of the Art and Future Opportunities 100
Lead Discovery of Dual G-Quadruplex Stabilizers and Poly(ADP-ribose) Polymerases (PARPs) Inhibitors: A New Avenue in Anticancer Treatment 98
Design, synthesis and characterization of aryl bis-guanyl hydrazones as RNA binders of C9orf72 G4C2 extended repeats 97
Phenylpyrazolo[1,5-a]quinazolin-5(4H)-one: a suitable scaffold for the development of non-camptothecin Topoisomerase I (Top1) inhibitors. 97
Ligand Binding to Telomeric DNA G-quadruplex through Metadynamics Calculations 97
Design, Synthesis, and Anticancer Activity of Drug-like Iron Chelators/G-Quadruplex Binders as Synergic Dual Targeting Agents 95
Overcoming the Lack of Oral Availability of Cyclic Hexapeptides: Design of a Selective and Orally Available Ligand for the Integrin αvβ3 92
The organometallic ferrocene exhibits amplified anti-tumor activity by targeted delivery via highly selective ligands to αvβ3, αvβ6, or α5β1 integrins 92
Molecular View on the iRGD Peptide Binding Mechanism: Implications for Integrin Activity and Selectivity Profiles 92
Binding mechanism of the farnesoid X receptor marine antagonist suvanine reveals a strategy to forestall drug modulation on nuclear receptors. Design, synthesis, and biological evaluation of novel ligands 89
Rational Improvement of the Affinity and Selectivity of Integrin Binding of Grafted Lasso Peptides 89
Targeting Glioblastoma Stem Cells via EphA2: Structural Insights into the RNA Aptamer A40s for Precision Therapy 86
Selective Targeting of Integrin αvβ8 by a Highly Active Cyclic Peptide 84
Bioinformatics and Biosimulations as Toolbox for Peptides and Peptidomimetics Design: Where Are We? 82
Structural Insight into the Binding Mode of FXR and GPBAR1 Modulators 81
Structure-based drug design targeting the cell membrane receptor GPBAR1: exploiting the bile acid scaffold towards selective agonism 80
N-Substituted Quinolinonyl Diketo Acid Derivatives as HIV Integrase Strand Transfer Inhibitors and Their Activity against RNase H Function of Reverse Transcriptase 79
Monothiocarbamates Strongly Inhibit Carbonic Anhydrases in Vitro and Possess Intraocular Pressure Lowering Activity in an Animal Model of Glaucoma 75
N-Methylation of isoDGR Peptides: Discovery of a Selective α5β1-Integrin Ligand as a Potent Tumor Imaging Agent 74
Synthesis of new oxadiazole derivatives as potent and selective FXR antagonists 73
Exploring the 1,3-benzoxazine chemotype for cannabinoid receptor 2 as a promising anti-cancer therapeutic 66
Exploring the chemical space of G-quadruplex binders: Discovery of a novel chemotype targeting the human telomeric sequence 66
Mechanistic insight into ligand binding to G-quadruplex DNA 64
Marine and semi-synthetic hydroxysteroids as new scaffolds for pregnane x receptor modulation. 62
New insights into the interaction between pyrrolyl diketoacids and HIV-1 integrase active site and comparison with RNase H 62
The Inhibition of DNA Viruses by the Amphibian Antimicrobial Peptide Temporin G: A Virological Study Addressing HSV-1 and JPCyV 55
Switching Roles─Exploring Concentration-Dependent Agonistic versus Antagonistic Behavior of Integrin Ligands 48
Vincristine Beyond Mitosis: Uncovering a First Link to G-Quadruplex DNA in Cancer Cells 46
Totale 8.849
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Categoria #
all - tutte 24.643
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 24.643
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/202166 0 0 0 0 0 0 0 0 0 12 25 29
2021/2022343 3 1 3 10 9 15 7 20 36 42 64 133
2022/2023481 61 31 17 27 65 52 0 48 72 59 36 13
2023/2024398 25 61 41 33 14 27 13 51 17 18 63 35
2024/20252.503 110 118 16 54 47 206 327 198 205 209 756 257
2025/20264.161 485 365 542 399 695 125 535 258 495 262 0 0
Totale 8.849