IRIS
COSIMELLI, BARBARA
 Distribuzione geografica
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Continente #
AS - Asia 2.786
NA - Nord America 2.740
EU - Europa 2.288
SA - Sud America 368
AF - Africa 45
Continente sconosciuto - Info sul continente non disponibili 3
OC - Oceania 2
Totale 8.232
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Nazione #
US - Stati Uniti d'America 2.648
SG - Singapore 1.502
RU - Federazione Russa 879
CN - Cina 463
IT - Italia 329
BR - Brasile 316
VN - Vietnam 315
HK - Hong Kong 256
UA - Ucraina 241
NL - Olanda 210
DE - Germania 137
FR - Francia 102
SE - Svezia 95
FI - Finlandia 93
IE - Irlanda 75
GB - Regno Unito 73
CA - Canada 57
IN - India 40
JP - Giappone 37
MX - Messico 28
TR - Turchia 23
BD - Bangladesh 20
IQ - Iraq 20
PH - Filippine 16
AR - Argentina 15
ID - Indonesia 14
TH - Thailandia 14
PL - Polonia 13
ZA - Sudafrica 13
PK - Pakistan 11
KR - Corea 10
ES - Italia 9
CI - Costa d'Avorio 8
EC - Ecuador 7
UZ - Uzbekistan 7
VE - Venezuela 7
BE - Belgio 6
CO - Colombia 6
MA - Marocco 6
CL - Cile 5
LB - Libano 5
PE - Perù 5
IL - Israele 4
NP - Nepal 4
PT - Portogallo 4
AO - Angola 3
AT - Austria 3
AZ - Azerbaigian 3
BO - Bolivia 3
KE - Kenya 3
MY - Malesia 3
OM - Oman 3
PS - Palestinian Territory 3
RS - Serbia 3
SY - Repubblica araba siriana 3
UY - Uruguay 3
CH - Svizzera 2
EG - Egitto 2
GR - Grecia 2
JO - Giordania 2
KZ - Kazakistan 2
LT - Lituania 2
MD - Moldavia 2
NE - Niger 2
NI - Nicaragua 2
SA - Arabia Saudita 2
AE - Emirati Arabi Uniti 1
AL - Albania 1
BB - Barbados 1
BF - Burkina Faso 1
BG - Bulgaria 1
BY - Bielorussia 1
CR - Costa Rica 1
CW - ???statistics.table.value.countryCode.CW??? 1
CZ - Repubblica Ceca 1
DK - Danimarca 1
DZ - Algeria 1
EU - Europa 1
GE - Georgia 1
HR - Croazia 1
KH - Cambogia 1
LY - Libia 1
MW - Malawi 1
NA - Namibia 1
NZ - Nuova Zelanda 1
PA - Panama 1
PY - Paraguay 1
RO - Romania 1
SD - Sudan 1
SK - Slovacchia (Repubblica Slovacca) 1
SN - Senegal 1
TN - Tunisia 1
TT - Trinidad e Tobago 1
TW - Taiwan 1
VC - Saint Vincent e Grenadine 1
WS - Samoa 1
XK - ???statistics.table.value.countryCode.XK??? 1
Totale 8.232
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Città #
Singapore 773
San Jose 372
Chandler 267
Jacksonville 252
Hong Kong 241
Amsterdam 201
Moscow 199
Ashburn 131
Beijing 131
The Dalles 99
Ho Chi Minh City 98
Princeton 91
Naples 90
Boston 84
Lauterbourg 81
Santa Clara 80
Millbury 79
Hanoi 70
Nanjing 66
Dallas 54
Los Angeles 53
Buffalo 51
Wilmington 50
Napoli 48
Tokyo 33
Boardman 31
Ottawa 30
Houston 26
São Paulo 25
New York 21
Nanchang 20
Hebei 19
Redondo Beach 19
Mexico City 18
Seattle 18
Shenyang 18
Des Moines 17
Jiaxing 17
Orem 17
Chicago 16
Da Nang 16
Frankfurt am Main 15
Hefei 15
Woodbridge 15
Redwood City 14
Ann Arbor 13
Council Bluffs 13
Warsaw 13
Kronberg 12
Brooklyn 11
Tianjin 11
Haiphong 10
London 10
Orange 10
San Francisco 10
Denver 9
Dublin 9
Norwalk 9
Rio de Janeiro 9
Belo Horizonte 8
Dong Ket 8
Montreal 8
Ankara 7
Baghdad 7
Changsha 7
Kunming 7
Porto Alegre 7
Rome 7
Tashkent 7
Como 6
Dhaka 6
Jinan 6
Phra Nakhon Si Ayutthaya 6
Seoul 6
Shenzhen 6
Atlanta 5
Biên Hòa 5
Bologna 5
Chennai 5
Istanbul 5
Jakarta 5
Johannesburg 5
Marigliano 5
Milan 5
Munich 5
Stockholm 5
Toronto 5
Abidjan 4
Betim 4
Brasília 4
Changchun 4
Charlotte 4
Columbus 4
Dronten 4
Goiânia 4
Lahore 4
Lima 4
Nha Trang 4
Ninh Bình 4
Phoenix 4
Totale 4.451
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Nome #
4-amino-6-alkyloxy-2-alkylthiopyrimidine derivatives as novel non-nucleoside agonists for the adenosine A1 receptor 213
Design, synthesis and biological evaluation of novel N-alkyl- and N-acyl-(7-substituted-2-phenylimidazo[1,2-a][1,3,5]triazin-4-yl)amines (ITAs) as novel A1 adenosine receptor antagonists 151
Studies on enantioselectivity of chiral 4-acetylamino-6-alkyloxy-2-alkylthiopyrimidines acting as antagonists of the human A3 adenosine receptor 140
3-Aryl-[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-one: a novel template for the design of highly selective A2B adenosine receptor antagonists 133
New Fluorescent 2-Phenylindolglyoxylamide Derivatives as Probes Targeting the Peripheral-Type Benzodiazepine Receptor: Design, Synthesis and Biological Evaluation. 129
A New Entry to Pyrazolo[1,5-a]pyrido[3,4-e]pyrimidine Derivatives. 120
Substituent effect on the electrochemical behaviour of some ortho-substituted (aryl)(2-nitrobenzo[b]thiophen-3-yl)amines. A combined experimental and computational study. 118
Zinc phthalocyanines and corresponding conjugates, their preparation and use in photodynamic therapy and as diagnostic agents. 117
Identification of novel indole derivatives acting as inhibitors of the Keap1–Nrf2 interaction 117
3-Aryl-[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-one: a novel template for the design of highly selective A2B adenosine receptor antagonists 116
Synthesis, Citotoxicity and Apoptosis Induction in Human Tumor Cells by Geiparvarin Analogues 115
Anxiolytic-like Effects of N,N-Dialkyl-2-phenylindol-3-ylglyoxylamides by Modulation of Translocator Protein Promoting Neurosteroid Biosynthesis. 113
TSPO-ligands prevent oxidative damage and inflammatory response in C6 glioma cells by neurosteroid synthesis 111
Synthesis and biological evaluation of imidazo[1,2-a]pyrimidines and imidazo[1,2-a]pyridines as new inhibitors of the Wnt/β-catenin signaling 109
2-Phenyl[1,2,3]triazolo[1,2-a][1,2,4]benzotriazin-1-one derivatives as a new class of adenosine receptor antagonists 107
1H and 13C NMR Study of the Pyrazolo[1,5-a]pyrimidine System. 106
Determination of the Absolute Configuration of a Chiral Oxadiazol-3-one Calcium Channel Blocker, Resolved by Using Chiral Chromatography, via Concerted Density Functional Theory Calculations of Its Vibrational Circular Dichroism, Electronic Circular Dichroism, and Optical Rotation. 105
2-(Benzimidazol-2-yl)quinoxalines: a Movel Class of Selective Antagonists at Human A(1) and A(3) Adenosine Receptors Designed by 3D Database Searching. 105
Allosteric Modulators of Human A2B Adenosine Receptor 105
A New Class of Selective Myocardial Calcium Channel Modulators. 2. The Role of the Acetal Chain in Oxadiazol-3-one Derivatives 104
5-Amino-2-phenyl[1,2,3]triazolo[1,2-a][1,2,4]benzotriazin-1-one: A Versatile Scaffold to Obtain Potent and Selective A3 Adenosine Receptor Antagonists. 103
Novel N2-substituted pyrazolo[3,4-d]pyrimidine adenosine A3 receptor antagonists: inhibition of A3-mediated human glioblastoma cell proliferation 102
Diltiazem Analogues: The Last Ten Years on Structure Activity Relationships. 101
Deepening the Topology of the Translocator Protein Binding Site by Novel N,N-Dialkyl-2-arylindol-3-ylglyoxylamides 101
Refinement of the Benzodiazepine Receptor Site Topology by Structure-Activity Relationships of New N-(Heteroarylmethyl)indol-3-ylglyoxylamides. 100
Identification of anxiolytic/non sedative agents among indol-3-ylglyoxylamides acting as functionally selective agonists at the GABAA alfa2 benzodiazepine receptor 100
Novel N-Substituted Indol-3-ylglyoxylamides Probing the LDi and L1/L2 Lipophilic Regions of the Benzodiazepine Receptor Site in Search for Subtype-Selective Ligands. 99
Calcium Channel Antagonists Discovered by a Multidisciplinary Approach. 98
New results on the reactivity of 5,6-diamino-4-hydroxy-2-mercaptopyrimidine 98
Chemistry of Substituted Pyrazolo[1,5-a]pyrimidines. Part 4. A Structural Correction of a Series of Pyrazolo[5',1':2,3]pyrimido[5,4-d][1,3]diazepines on the Basis of NMR Spectroscopy and X-Ray Diffraction Analysis. 95
8H-Pyrazolo[5',1':2,3]pyrimido[5,4-d][1,2]diazepine: A New Tricyclic System. 94
Alkali-metal Complexes with Neutral Molecular Receptors containing Nitrogen Donor Atoms: a Crystallographic and Multinuclear Magnetic Resonance Study. 91
A novel approach to the evaluation of the importance of steric and electronic effects in SNAr reactions: a computational, thermodynamic, 1H and 13C NMR study of “Meisenheimer-type” adducts in the benzo[b]thiophene series 91
A convenient synthesis of psoralens. 89
Chemistry of Substituted Pyrazolo[1,5-a]pyrimidines. Part 3. A Structural Correc¬tion of Pyrazolo[1,5-a][1,3]diazepine Derivative on the Basis of 13C NMR Spectroscopy. 89
Allosteric modulation of A2B adenosine receptors potentiate the effects of orthosteric receptor agonists to promote mesenchymal stem cell differentiation to osteoblasts 88
New geiparvarin analogues from 7-(2-oxoethoxy)coumarins as efficient in vitro antitumoral agents. 88
On the Nitration of 5-Phenyl- and 3-Methyl-5-phenylisoxazole. 88
A1 adenosine receptor antagonists, 3-aryl[1,2,4]triazino[4,3-a]benzimidazol-4-(10H)-ones (ATBIs) and N-alkyl and N-acyl-(7-substituted-2-phenylimidazo[1,2-a][1,3,5]triazin-4-yl)amines (ITAs): Different recognition of bovine and human binding sites 88
Mononuclear Heterocyclic Rearrangements. Part 16. Kinetic Study of the Rearrangement of Some ortho-Substituted Z-Phenylhydrazones of 3-Benzoyl-5-phenyl-1,2,4-oxadiazole into 2-Aryl-4-benzoylamino-5-phenyl-1,2,3-triazoles in Dioxane-Water and in Benzene. 87
A New Synthetic Route to 2,2’:5’,2”-Terthiophene-5-derivatives to Conjugate with Proteins and Monoclonal Antibodies. 87
Understanding Oxadiazolothiazinone Biological Properties: Negative Inotropic Activity versus Cytochrome P450-Mediated Metabolism 87
Cardiovascular characterization of [1,4]thiazino[3,4-c][1,2,4]oxadiazol-3-one-derivatives: selective myocardial calcium channel modulators. 86
A New Convenient Route to 2-Oxoethoxycoumarins: Key Intermediates in the Synthesis of Natural Products. 86
Studies on Azole-to-Azole Interconversion. An Interesting Case of Absence of “Primary Steric Effect” in the Ring-degenerate Equilibration between ortho-Substituted 3-Aroylamino-5-methyl-1,2,4-oxadiazoles and 3-Acetylamino-5-aryl-1,2,4-oxadiazoles in Methanol. 85
Derivatives of 4-Amino-6-hydroxy-2-mercaptopyrimidine as Novel, Potent, and Selective A3 Adenosine Receptor Antagonists 85
Enantiomeric 4-Acylamino-6-alkyloxy-2 Alkylthiopyrimidines As Potential A3 Adenosine Receptor Antagonists: HPLC Chiral Resolution and Absolute Configuration Assignment by a Full Set of Chiroptical Spectroscopy 85
Ring opening of 2-substituted 4-nitrothiophenes with pyrrolidine. Access to new functionalized nitro-unsaturated building blocks. 84
Natural and Synthetic Geiparvarins Are Strong and Selective MAO-B Inhibitors. Synthesis and SAR Studies. 84
Carbon-13 NMR Studies on Azolopyridines. 3-The Isothiazolopyridine Systems. 82
From the central benzodiazepine receptor to the adenosine receptors exploiting the 3-diketoindole moiety 82
Studies in organic mass spectrometry. Part 24 Electron ionization mass spectra of some aryl(2-nitrobenzo[b]thiophen-3-yl)amines. 81
Determination of the absolute configuration of the enantiomers of an oxadiazol-3-one calcium channel blocker, resolved by chiral HPLC, via concerted use of three chiroptical spectroscopies 81
Synthesis and antimycotic activity of new unsymmetrical substituted zinc phthalocyanines. 80
Pyrazolo[1,5-a]pyrido[3,4-e]pyrimidine: A New Heterocyclic Ring System. 80
From the Pharmacophore to the Homology Model of the Benzodiazepine Receptor: The Indolyglyoxylamides Affair. 80
Ring-ring Interconversions of Nitrosoimidazoles. The Effect of Some Condensed Six-membered Rings on the Reactivity. 79
On the reaction of 3-bromo-2-nitrobenzo[b]thiophene with some ortho-substituted anilines: an analysis of the products of reaction and of their NMR and MS properties 79
Novel Irreversible Fluorescent Probes Targeting the 18kDa Translocator Protein: Synthesis and Biological Characterization. 79
The First Kinetic Evidence for Acid Catalysis in a Monocyclic Rearrangement of Heterocycles: Conversion of the Z-Phenylhydrazone of 5-Amino-3-benzoyl-1,2,4-oxadiazole into N,5-Diphenyl-2H-1,2,3-triazol-4-ylurea 78
Substituent effect on the redox potential of some substituted (aryl)(2-nitrobenzo[b]thiophen-3-yl)amines. 78
High Affinity Central Benzodiazepine Receptor Ligands: Synthesis and Biological Evaluation of a Series of Phenyltriazolobenzotriazindione Derivatives (PTBTs) 78
Ring-ring interconversions. Part 2. Effect of the Substituent on the Rearrangement of 6-Aryl-3-methyl-5-nitrosoimidazo[2,1-b][1,3]thiazoles into 8-Aryl-8-hydroxy-5-methyl-8H-[1,4]thiazino[3,4-c][1,2,4]oxadiazol-3-ones. A Novel Class of Potential Antitumor Agents. 77
Ring-ring Interconversions. Part 3. On the effect of the substituents on the thiazole moiety in the ring-opening/ring-closing reactions of nitrosoimidazo[2,1-b][1,3]thiazoles with hydrochloric acid. 77
Unambiguous Structure Determination of Some Pyrazolo[1,5-a]pyrimidine Derivatives by Multinuclear NMR Spectroscopy. 77
New 5-(2-ethenylsubstituted)-3(2H)-furanones with in vitro antiproliferative activity 76
Modulation of A2B adenosine receptor by 1-Benzyl-3-ketoindole derivatives 76
On the Reactivity of 3-Bromo-2-nitrobenzo[b]thiophene with Nucleophiles: Elucidation of the Base-Catalyzed Mechanism with Rearrangement. 75
Regioselective Synthesis of 4-Acetyl- and 5-Acetyl-3-methylisoxazole: their Conversion into Silyl- and Methyl Enol Ethers. 74
ABCB1 Structural Models, Molecular Docking, and Synthesis of New Oxadiazolothiazin-3-one Inhibitors 74
Synthesis and L-type calcium channel blocking activity of new chiral oxadiazolothiazinones 74
On the Synthesis and Reactivity of the Z-2,4-Dinitrophenylhydrazone of 5-Amino-3-benzoyl-1,2,4-oxadiazole. 73
On the reactivity of nitrosoimidazoles with acids (the Cusmano-Ruccia reaction): a continuous source of new ring-into-ring interconversion 73
Derivatives of benzimidazol-2-ylquinoline and benzimidazol-2-ylisoquinoline as selective A1 adenosine receptor antagonists with stimulant activity on human colon motility 72
An Unexpected Pathway to Enantiomerization of Hemithioketals in Toluene Involving a Dimeric Transition State: A Combined Experimental and Computational Study 71
The P-glycoprotein inhibitor diltiazem-like 8-(4-chlorophenyl)-5-methyl-8-[(2Z)-pent-2-en-1-yloxy]-8H-[1,2,4]oxadiazolo[3,4-c][1,4]thiazin-3-one inhibits esterase activity and H3 histone acetylation 71
Ring-ring interconversion: the rearrangement of 6-(4-chlorophenyl)-3-methyl-5-nitrosoimidazo[2,1-b][1,3]thiazole into 8-(4-chlorophenyl)-8-hydroxy-5-methyl-8H-[1,4]thiazino[3,4-c][1,2,4]oxadiazol-3-one. Elucidation of the reaction product through spectroscopic and X-ray crystal structure analysis. 69
L-Type calcium channel blockers: from diltiazem to 1,2,4-oxadiazol-5-ones via thiazinooxadiazol-3-one derivatives 69
Absolute configuration and biological profile of two thiazinooxadiazol-3-ones with L-type calcium channel activity: a study of the structural effects 69
Synthesis and biological evaluation on human glioblastoma cells of novel pyrazolo[3,4-d]pyrimidine adenosine A(3) receptor antagonists 69
Complete 1H (600 MHz) and 13C NMR Spectral Assignment of 3,4-bis[(3,4-Dimethoxyphenyl)methyl]dihydro-(3R-trans)-2(3H)-furanone (Matairesinol Dimethyl Ether), a Naturally Occurring Dibenzylbutyrolactone Lignan. 68
Chemistry of substituted pyrazolo[1,5-a]pyrimidines. Part 5. 7-Oxo-6-[pyrazol-3’(5’)-yl]-4,7-dihydropyrazolo[1,5-a]pyrimidines from 6-ethoxycarbonyl-7-(2-dimethylaminovinyl)-pyrazolo[1,5-a]pyrimidines: elucidation of the reaction mechanism through NMR spectroscopy and X-Ray diffraction analysis. 68
Osteoblast differentiation and survival: A role for A2B adenosine receptor allosteric modulators 67
Novel fluorescent triazinobenzimidazole derivatives as probes for labelling human A1 and A2B adenosine receptor subtypes 66
The Boulton–Katritzky Reaction: A Kinetic Study of the Effect of 5-Nitrogen Substituents on the Rearrangement of Some (Z)-Phenylhydrazones of 3-Benzoyl-1,2,4-oxadiazoles 65
ortho-Substituted (aryl)(3-nitrobenzo[b]thiophen-2-yl)amines: study of the electrochemical behavior 62
Playing with Opening and Closing of Heterocycles: Using the Cusmano-Ruccia Reaction to Develop a Novel Class of Oxadiazolothiazinones, Active as Calcium Channel Modulators and P-Glycoprotein Inhibitors 62
First example of Diels-Alder reaction of 4-(1-ethenylsubstituted)-3-methylisoxazoles with acetylenedicarboxylate 61
Tertiary amides with a five-membered heteroaromatic ring as new probes for the translocator protein 61
Discovery of novel and cardioselective diltiazem-like calcium channel blockers via virtual screening. 60
Selective and Practical Oxidation of Sulfides to Diastereopure Sulfoxides: A Combined Experimental and Computational Investigation 59
Preliminary Finding on a New Calcium Channel Entry Blocker Chemotype: 5,6-Diamino-4-hydroxy-2-mercaptopyrimidine Derivatives 59
p53 Functional Inhibitors Behaving Like Pifithrin-? Counteract the Alzheimer Peptide Non-?-amyloid Component Effects in Human SH-SY5Y Cells 59
Inhibition of MDR1 activity in vitro by a novel class of diltiazem analogues: towards new candidates 55
Totale 8.318
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Categoria #
all - tutte 30.425
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 30.425
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/202119 0 0 0 0 0 0 0 0 0 0 0 19
2021/2022422 18 1 3 3 3 6 5 17 78 3 78 207
2022/2023743 107 64 9 72 73 50 4 48 81 193 29 13
2023/2024356 27 62 105 26 12 8 1 29 1 3 44 38
2024/20252.121 124 167 6 4 31 71 269 142 210 179 720 198
2025/20263.223 438 213 304 271 598 164 380 222 336 205 85 7
Totale 8.318