The chemical synthesis of two new G-rich Tetra-End-Linked-oligodeoxyribonucleotides (TEL-ODNs) as well as (1)H-NMR and CD spectra of the corresponding monomolecular quadruplexes (IVa and IVb) has been reported. The new TEL-ODNs, characterized by the presence of short branches in the linker moiety, could be very useful for the achievement of monomolecular quadruplexes with predetermined strand orientation.
Synthesis and characterization of tetra-end linked oligonucleotides capable of forming monomolecular G-quadruplex / Borbone, Nicola; Oliviero, Giorgia; Amato, Jussara; D'Errico, Stefano; Galeone, Aldo; Piccialli, Gennaro; Mayol, Luciano. - In: NUCLEOSIDES, NUCLEOTIDES & NUCLEIC ACIDS. - ISSN 1525-7770. - STAMPA. - 26:(2007), pp. 1231-1236. [10.1080/15257770701528172]
Synthesis and characterization of tetra-end linked oligonucleotides capable of forming monomolecular G-quadruplex
BORBONE, NICOLA;OLIVIERO, GIORGIA;AMATO, JUSSARA;D'ERRICO, STEFANO;GALEONE, ALDO;PICCIALLI, GENNARO;MAYOL, LUCIANO
2007
Abstract
The chemical synthesis of two new G-rich Tetra-End-Linked-oligodeoxyribonucleotides (TEL-ODNs) as well as (1)H-NMR and CD spectra of the corresponding monomolecular quadruplexes (IVa and IVb) has been reported. The new TEL-ODNs, characterized by the presence of short branches in the linker moiety, could be very useful for the achievement of monomolecular quadruplexes with predetermined strand orientation.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
