Background: Radical cystectomy (RC) is the gold standard treatment for muscle-invasive bladder cancer (BCa). Chronic liver disease (CLD) may predispose to worse in-hospital outcomes after RC and ileal conduit, but this association has not been investigated. The current study addressed this knowledge gap. Methods: Descriptive analyses, propensity score-matching (PSM), and multivariable logistic and Poisson regression models were used to address BCa patients in the National Inpatient Sample treated with RC and ileal conduit (2006–2019). Results: Of 15,104 RC and ileal conduit patients, 241 (1.6 %) had CLD at baseline. Compared with their non-CLD counterparts, the CLD patients exhibited significantly higher rates of adverse in-hospital outcomes in 9 of 13 categories, namely, acute kidney injury (AKI, Δ+12.0 %), overall complications (Δ+11.0 %), pulmonary complications (Δ+9.0 %), blood transfusions (Δ+8.0 %), prolonged hospital stay (Δ+7.0 %), infectious complications (Δ+7.0 %), critical care therapies (Δ+4.0 %), in-hospital mortality (Δ+3.6 %), and total hospital charges (THC, Δ+18, 042 US$) (all p < 0.05). After multivariable adjustment, CLD independently predicted higher rates of adverse in-hospital outcomes in the same categories, namely, in-hospital mortality (odds ratio [OR], 2.7; 95 % confidence interval [CI], 1.3–4.9), infectious complications (OR, 2.5; 95 % CI 1.6–3.8), AKI (OR, 2.1; 95 % CI 1.6–2.9), pulmonary complications (OR, 2.0; 95 % CI 1.4–2.8), overall complications (OR, 1.9; 95 % CI 1.7–2.9), critical care therapies (OR, 1.6; 95 % CI 1.2–1.9), blood transfusions (OR, 1.4; 95 % CI 1.1–1.9), prolonged hospital stay (OR, 1.4; 95 % CI 1.1–1.8), and THC (OR, 1.2; 95 % CI 1.1–1.4) (all p < 0.05). Conclusions: Although CLD appears to predispose to higher rates of adverse in-hospital outcomes after RC and ileal conduit, it does not increase the rates of these outcomes in a prohibitive fashion.
The Effect of Chronic Liver Disease on Adverse In-Hospital Outcomes After Radical Cystectomy and Ileal Conduit Urinary Diversion / Polverino, Federico; Marmiroli, Andrea; Longoni, Mattia; Le, Quynh Chi; Falkenbach, Fabian; Nicolazzini, Michele; Catanzaro, Calogero; Saad, Fred; Goyal, Jordan A.; Morra, Simone; Califano, Gianluigi; La Rocca, Roberto; Ruvolo, Claudia Collà; Briganti, Alberto; Chun, Felix K. H.; Graefen, Markus; Palumbo, Carlotta; Schiavina, Riccardo; Musi, Gennaro; Shariat, Shahrokh F.; Longo, Nicola; Karakiewicz, Pierre I.. - In: ANNALS OF SURGICAL ONCOLOGY. - ISSN 1068-9265. - (2025). [10.1245/s10434-025-18032-y]
The Effect of Chronic Liver Disease on Adverse In-Hospital Outcomes After Radical Cystectomy and Ileal Conduit Urinary Diversion
Polverino, Federico;Morra, Simone;Califano, Gianluigi;La Rocca, Roberto;Musi, Gennaro;Longo, Nicola;
2025
Abstract
Background: Radical cystectomy (RC) is the gold standard treatment for muscle-invasive bladder cancer (BCa). Chronic liver disease (CLD) may predispose to worse in-hospital outcomes after RC and ileal conduit, but this association has not been investigated. The current study addressed this knowledge gap. Methods: Descriptive analyses, propensity score-matching (PSM), and multivariable logistic and Poisson regression models were used to address BCa patients in the National Inpatient Sample treated with RC and ileal conduit (2006–2019). Results: Of 15,104 RC and ileal conduit patients, 241 (1.6 %) had CLD at baseline. Compared with their non-CLD counterparts, the CLD patients exhibited significantly higher rates of adverse in-hospital outcomes in 9 of 13 categories, namely, acute kidney injury (AKI, Δ+12.0 %), overall complications (Δ+11.0 %), pulmonary complications (Δ+9.0 %), blood transfusions (Δ+8.0 %), prolonged hospital stay (Δ+7.0 %), infectious complications (Δ+7.0 %), critical care therapies (Δ+4.0 %), in-hospital mortality (Δ+3.6 %), and total hospital charges (THC, Δ+18, 042 US$) (all p < 0.05). After multivariable adjustment, CLD independently predicted higher rates of adverse in-hospital outcomes in the same categories, namely, in-hospital mortality (odds ratio [OR], 2.7; 95 % confidence interval [CI], 1.3–4.9), infectious complications (OR, 2.5; 95 % CI 1.6–3.8), AKI (OR, 2.1; 95 % CI 1.6–2.9), pulmonary complications (OR, 2.0; 95 % CI 1.4–2.8), overall complications (OR, 1.9; 95 % CI 1.7–2.9), critical care therapies (OR, 1.6; 95 % CI 1.2–1.9), blood transfusions (OR, 1.4; 95 % CI 1.1–1.9), prolonged hospital stay (OR, 1.4; 95 % CI 1.1–1.8), and THC (OR, 1.2; 95 % CI 1.1–1.4) (all p < 0.05). Conclusions: Although CLD appears to predispose to higher rates of adverse in-hospital outcomes after RC and ileal conduit, it does not increase the rates of these outcomes in a prohibitive fashion.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
