Cancer immunotherapy, particularly immune checkpoint inhibitors (ICI), has revolutionized oncology treatment by leveraging the immune system to recognize and eliminate cancer cells. However, despite its efficacy, immunotherapy may induce immune-related adverse events (irAEs), including dermatological events, that can range from mild rashes to severe life-threatening conditions such as toxic epidermal necrolysis. This paper aims to explore and analyse the preventive measures for cutaneous irAEs (cirAEs). By identifying risk factors, recognizing early signs and implementing preventive strategies, healthcare professionals can significantly mitigate the severity of irAEs, thereby improving patient outcomes and quality of life.
Prevention and management of cutaneous immune‐related adverse events: EADV Task Force statement / Fattore, Davide; Apalla, Zoe; Freites‐martinez, Azael; Tommasino, Nello; Nikolaou, Vasiliki; Lauletta, Giuseppe; Ortiz‐brugues, Ariadna; Sollena, Pietro; Starace, Michela; Gomes, Nuno Miguel Preto; Koumaki, Dimitra; Vigarios, Emmanuelle; Kraehenbuehl, Lukas; Grafanaki, Katerina; Napolitano, Maddalena; Sibaud, Vincent. - In: JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY. - ISSN 0926-9959. - (2025). [10.1111/jdv.70149]
Prevention and management of cutaneous immune‐related adverse events: EADV Task Force statement
Fattore, Davide;Tommasino, Nello;Lauletta, Giuseppe;Napolitano, Maddalena;
2025
Abstract
Cancer immunotherapy, particularly immune checkpoint inhibitors (ICI), has revolutionized oncology treatment by leveraging the immune system to recognize and eliminate cancer cells. However, despite its efficacy, immunotherapy may induce immune-related adverse events (irAEs), including dermatological events, that can range from mild rashes to severe life-threatening conditions such as toxic epidermal necrolysis. This paper aims to explore and analyse the preventive measures for cutaneous irAEs (cirAEs). By identifying risk factors, recognizing early signs and implementing preventive strategies, healthcare professionals can significantly mitigate the severity of irAEs, thereby improving patient outcomes and quality of life.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.


