Clavaminols A-F, novel cytotoxic 2-amino-3-alkanols from the ascidian Clavelina phlegraea

The chemical investigation of the Mediterranean ascidian Clavelina phlegraea has led to the isolation of six new 2-amino- 3-alkanol derivatives, clavaminols A–F (1–6). Their stereostructures were established by analysis of spectroscopic data and chemical conversion. Clavaminols A, B, C, and F were tested for their cytotoxic and pro-apoptotic properties and clavaminol A was shown to be the more potent cytotoxic compound of this series inducing cell death through activation of the apoptotic machinery.