Abstract: Autologous second-generation CD7-directed chimeric antigen receptor T cells, expressing an anti-CD7 protein expression blocker to prevent self-killing fratricide, were infused in 3 pediatric/young adult patients with relapsed/refractory CD7+ acute myeloid leukemia, resulting in measurable residual disease negativity. The safety profile was favorable.

Anti-CD7 fratricide-resistant chimeric antigen receptor T cells for relapsed/refractory acute myeloid leukemia / Becilli, Marco; Merli, Pietro; Algeri, Mattia; Del Bufalo, Francesca; Pagliara, Daria; Bertaina, Valentina; Agrati, Chiara; Rosignoli, Chiara; Cefalo, Maria Giuseppina; Boccieri, Emilia; Di Cecca, Stefano; Iaffaldano, Laura; Lee, Yunqin; De Angelis, Biagio; Meshinchi, Soheil; Quintarelli, Concetta; Campana, Dario; Locatelli, Franco. - In: BLOOD. - ISSN 1528-0020. - (2026). [10.1182/blood.2025032299]

Anti-CD7 fratricide-resistant chimeric antigen receptor T cells for relapsed/refractory acute myeloid leukemia

Merli, Pietro;Iaffaldano, Laura;De Angelis, Biagio;Quintarelli, Concetta;Locatelli, Franco
2026

Abstract

Abstract: Autologous second-generation CD7-directed chimeric antigen receptor T cells, expressing an anti-CD7 protein expression blocker to prevent self-killing fratricide, were infused in 3 pediatric/young adult patients with relapsed/refractory CD7+ acute myeloid leukemia, resulting in measurable residual disease negativity. The safety profile was favorable.
2026
Anti-CD7 fratricide-resistant chimeric antigen receptor T cells for relapsed/refractory acute myeloid leukemia / Becilli, Marco; Merli, Pietro; Algeri, Mattia; Del Bufalo, Francesca; Pagliara, Daria; Bertaina, Valentina; Agrati, Chiara; Rosignoli, Chiara; Cefalo, Maria Giuseppina; Boccieri, Emilia; Di Cecca, Stefano; Iaffaldano, Laura; Lee, Yunqin; De Angelis, Biagio; Meshinchi, Soheil; Quintarelli, Concetta; Campana, Dario; Locatelli, Franco. - In: BLOOD. - ISSN 1528-0020. - (2026). [10.1182/blood.2025032299]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/1049877
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