: Obesity, asthma, and allergic diseases are among the major chronic noncommunicable diseases that are rapidly increasing worldwide. These conditions are often interconnected, sharing common epidemiologic trends and pathophysiological mechanisms. In pediatric populations, substantial epidemiologic evidence demonstrates that obesity is associated with an increased risk of asthma and certain allergic diseases, greater disease severity, poorer control, and reduced quality of life. Importantly, these associations may originate early in life, with maternal obesity acting as a critical driver of offspring susceptibility. Multiple mechanisms underlie this complex interplay, including chronic low-grade inflammation, adipokine dysregulation, and alterations in gut microbiota and intestinal epithelial barrier integrity. In this scenario, diet emerges as a shared environmental driver of these conditions and consequently as a promising preventive and therapeutic target. Nutritional assessment and targeted dietary interventions from early life, including during pregnancy, offer a unique opportunity to improve both metabolic health and asthma/allergic outcomes, potentially reducing disease severity, optimizing drug effectiveness, and improving overall quality of life.

Obesity, asthma, and allergy triangle:The solution could be the diet / Coppola, S., Agizza, A., Iorio, R.F., Carucci, L., Oglio, F., Caldaria, E., Cadavere, A., Berni Canani, R.. - In: ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY. - ISSN 1081-1206. - (2026). [10.1016/j.anai.2026.07.030]

Obesity, asthma, and allergy triangle:The solution could be the diet.

Coppola, Serena;Agizza, Alessandra;Iorio, Raffaele Federico;Carucci, Laura;Oglio, Franca;Caldaria, Erika;Cadavere, Alessia;Berni Canani, Roberto
2026

Abstract

: Obesity, asthma, and allergic diseases are among the major chronic noncommunicable diseases that are rapidly increasing worldwide. These conditions are often interconnected, sharing common epidemiologic trends and pathophysiological mechanisms. In pediatric populations, substantial epidemiologic evidence demonstrates that obesity is associated with an increased risk of asthma and certain allergic diseases, greater disease severity, poorer control, and reduced quality of life. Importantly, these associations may originate early in life, with maternal obesity acting as a critical driver of offspring susceptibility. Multiple mechanisms underlie this complex interplay, including chronic low-grade inflammation, adipokine dysregulation, and alterations in gut microbiota and intestinal epithelial barrier integrity. In this scenario, diet emerges as a shared environmental driver of these conditions and consequently as a promising preventive and therapeutic target. Nutritional assessment and targeted dietary interventions from early life, including during pregnancy, offer a unique opportunity to improve both metabolic health and asthma/allergic outcomes, potentially reducing disease severity, optimizing drug effectiveness, and improving overall quality of life.
2026
Obesity, asthma, and allergy triangle:The solution could be the diet / Coppola, S., Agizza, A., Iorio, R.F., Carucci, L., Oglio, F., Caldaria, E., Cadavere, A., Berni Canani, R.. - In: ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY. - ISSN 1081-1206. - (2026). [10.1016/j.anai.2026.07.030]
File in questo prodotto:
File Dimensione Formato  
Obesity, asthma, and allergy triangle.pdf

accesso aperto

Tipologia: Documento in Post-print
Licenza: Dominio pubblico
Dimensione 1.24 MB
Formato Adobe PDF
1.24 MB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/1067254
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact