The synthesis and characterization of two five-coordinate platinum(II) complexes of general formula [PtCl(SnMe(n)Cl3-n)(2,9-Me2-1,10-phenanthroline) (diethylfumarate)] (n = 1, 2) are described. The bimetallic species were tested on the neuroblastoma cell line SK-N-BE and a considerable inhibition of cellular proliferation was detected; the bimetallic species were also able to induce neuronal differentiation, as did retinoic acid, a well-known neuroblastoma differentiating agent.
Synthesis and biological activity of five-coordinate platinum(II)complexes including organotin fragments / Carpinelli, P.; Bartolucci, Simonetta; Ruffo, Francesco. - In: ANTI-CANCER DRUG DESIGN. - ISSN 0266-9536. - STAMPA. - 10:1(1995), pp. 43-49.
Synthesis and biological activity of five-coordinate platinum(II)complexes including organotin fragments.
BARTOLUCCI, SIMONETTA;RUFFO, FRANCESCO
1995
Abstract
The synthesis and characterization of two five-coordinate platinum(II) complexes of general formula [PtCl(SnMe(n)Cl3-n)(2,9-Me2-1,10-phenanthroline) (diethylfumarate)] (n = 1, 2) are described. The bimetallic species were tested on the neuroblastoma cell line SK-N-BE and a considerable inhibition of cellular proliferation was detected; the bimetallic species were also able to induce neuronal differentiation, as did retinoic acid, a well-known neuroblastoma differentiating agent.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
