Three polymeric supports (polystyrene, Tentagel and controlled pore glass) have been tested for solid phase synthesis of oligosaccharides based on the trichloroacetimidate methodology, Controlled pore glass has been found to yield satisfactory results with TMSOTf as the glycosylation promoter. An application to the on-line preparation of a glyconucleotide is also reported.
Use of controlled pore glass in solid phase oligosaccharide synthesis. Application to the semiautomated synthesis of a glyconucleotide conjugate / Adinolfi, Matteo; Barone, Gaspare; DE NAPOLI, Lorenzo; Iadonisi, Alfonso; Piccialli, Gennaro. - In: TETRAHEDRON LETTERS. - ISSN 0040-4039. - STAMPA. - 39:14(1998), pp. 1953-1956. [10.1016/S0040-4039(98)00103-8]
Use of controlled pore glass in solid phase oligosaccharide synthesis. Application to the semiautomated synthesis of a glyconucleotide conjugate.
ADINOLFI, MATTEO;BARONE, GASPARE;DE NAPOLI, LORENZO;IADONISI, ALFONSO;PICCIALLI, GENNARO
1998
Abstract
Three polymeric supports (polystyrene, Tentagel and controlled pore glass) have been tested for solid phase synthesis of oligosaccharides based on the trichloroacetimidate methodology, Controlled pore glass has been found to yield satisfactory results with TMSOTf as the glycosylation promoter. An application to the on-line preparation of a glyconucleotide is also reported.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
