A chemical investigation of the digestive glands of Mytilus galloprovincialis from North Adriatic Sea led to the isolation of three novel compounds, oxazinin-1 (1), oxazinin-2 (2) and oxazinin-3 (3). Their structures, including the relative stereochemistry, were established by spectroscopic means including extensive 2D NMR and molecular mechanics calculations. The new compounds were analyzed for cytotoxic activity and oxazinin-1 (1) was shown to inhibit the growth of WEHI 164 and J774 cell lines in vitro.

Oxazinin-1, -2 and –3 – A novel toxic compound and its analogues from the digestive glands of Mytilus galloprovincialis / Ciminiello, Patrizia; Dell'Aversano, Carmela; Fattorusso, Ernesto; Forino, Martino; S., Magno; Ianaro, Angela; M., Dirosa. - In: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. - ISSN 1434-193X. - STAMPA. - (2001), pp. 49-53.

Oxazinin-1, -2 and –3 – A novel toxic compound and its analogues from the digestive glands of Mytilus galloprovincialis

CIMINIELLO, PATRIZIA;DELL'AVERSANO, CARMELA;FATTORUSSO, ERNESTO;FORINO, MARTINO;IANARO, ANGELA;
2001

Abstract

A chemical investigation of the digestive glands of Mytilus galloprovincialis from North Adriatic Sea led to the isolation of three novel compounds, oxazinin-1 (1), oxazinin-2 (2) and oxazinin-3 (3). Their structures, including the relative stereochemistry, were established by spectroscopic means including extensive 2D NMR and molecular mechanics calculations. The new compounds were analyzed for cytotoxic activity and oxazinin-1 (1) was shown to inhibit the growth of WEHI 164 and J774 cell lines in vitro.
2001
Oxazinin-1, -2 and –3 – A novel toxic compound and its analogues from the digestive glands of Mytilus galloprovincialis / Ciminiello, Patrizia; Dell'Aversano, Carmela; Fattorusso, Ernesto; Forino, Martino; S., Magno; Ianaro, Angela; M., Dirosa. - In: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. - ISSN 1434-193X. - STAMPA. - (2001), pp. 49-53.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/144078
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