A chemical investigation of the digestive glands of Mytilus galloprovincialis from North Adriatic Sea led to the isolation of three novel compounds, oxazinin-1 (1), oxazinin-2 (2) and oxazinin-3 (3). Their structures, including the relative stereochemistry, were established by spectroscopic means including extensive 2D NMR and molecular mechanics calculations. The new compounds were analyzed for cytotoxic activity and oxazinin-1 (1) was shown to inhibit the growth of WEHI 164 and J774 cell lines in vitro.
Oxazinin-1, -2 and –3 – A novel toxic compound and its analogues from the digestive glands of Mytilus galloprovincialis / Ciminiello, P., Dell'Aversano, C., Fattorusso, E., Forino, M., S., M., Ianaro, A., M., D.. - In: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. - ISSN 1434-193X. - STAMPA. - (2001), pp. 49-53.
Oxazinin-1, -2 and –3 – A novel toxic compound and its analogues from the digestive glands of Mytilus galloprovincialis
CIMINIELLO, PATRIZIA;DELL'AVERSANO, CARMELA;FATTORUSSO, ERNESTO;FORINO, MARTINO;IANARO, ANGELA;
2001
Abstract
A chemical investigation of the digestive glands of Mytilus galloprovincialis from North Adriatic Sea led to the isolation of three novel compounds, oxazinin-1 (1), oxazinin-2 (2) and oxazinin-3 (3). Their structures, including the relative stereochemistry, were established by spectroscopic means including extensive 2D NMR and molecular mechanics calculations. The new compounds were analyzed for cytotoxic activity and oxazinin-1 (1) was shown to inhibit the growth of WEHI 164 and J774 cell lines in vitro.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
