Ras proteins are membrane-associated transducers of eternal stimuli to unknown intracellular targets. The constitutively activated v-ras oncogene induces dedifferentiation in thyroid cells. v-Ras appears to act by stimulating protein kinase C (PKC), which inhibits the nuclear migration of the catalytic subunit of the cAMP-dependent protein kinase A (PKA). Nuclear tissue-specific and housekeeping trans-acting factors that are dependent on phosphorylation by PKA are thus inactivated. Exclusion of the PKA subunit from the nucleus could represent a general mechanism for the pleiotropic effects of Ras and PKC on cellular growth and differentiation.

v-ras and protein kinase C dedifferentiate thyroid cells by down-regulating nuclear cAMP-dependent protein kinase A / Gallo, A.; Benusiglio, E.; Bonapace, I. M.; Feliciello, Antonio; Cassano, S.; Garbi, Corrado; Musti, A. M.; Gottesman, M. E.; Avvedimento, VITTORIO ENRICO. - In: GENES & DEVELOPMENT. - ISSN 0890-9369. - STAMPA. - 6:(1992), pp. 1621-1630.

v-ras and protein kinase C dedifferentiate thyroid cells by down-regulating nuclear cAMP-dependent protein kinase A.

FELICIELLO, ANTONIO;GARBI, CORRADO;AVVEDIMENTO, VITTORIO ENRICO
1992

Abstract

Ras proteins are membrane-associated transducers of eternal stimuli to unknown intracellular targets. The constitutively activated v-ras oncogene induces dedifferentiation in thyroid cells. v-Ras appears to act by stimulating protein kinase C (PKC), which inhibits the nuclear migration of the catalytic subunit of the cAMP-dependent protein kinase A (PKA). Nuclear tissue-specific and housekeeping trans-acting factors that are dependent on phosphorylation by PKA are thus inactivated. Exclusion of the PKA subunit from the nucleus could represent a general mechanism for the pleiotropic effects of Ras and PKC on cellular growth and differentiation.
1992
v-ras and protein kinase C dedifferentiate thyroid cells by down-regulating nuclear cAMP-dependent protein kinase A / Gallo, A.; Benusiglio, E.; Bonapace, I. M.; Feliciello, Antonio; Cassano, S.; Garbi, Corrado; Musti, A. M.; Gottesman, M. E.; Avvedimento, VITTORIO ENRICO. - In: GENES & DEVELOPMENT. - ISSN 0890-9369. - STAMPA. - 6:(1992), pp. 1621-1630.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/146063
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