A protocol for the synthesis of triplex forming oligonucleotides containing a chelating molecule in the 3'-3' inversion site of polarity is reported. A number of 16-mers have been synthesized and UV spectroscopy employed to evaluate the stability of their triple helix complexes with the pertinent double-strand oligonucleotide targets.
Synthesis of triple helix forming oligonucleotides with a phenanthroline moiety into the 3’-3’ inversion site of polarity / Esposito, Veronica; Galeone, Aldo; Mayol, Luciano; Oliviero, Giorgia; Randazzo, Antonio; Varra, Michela. - In: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. - ISSN 1434-193X. - STAMPA. - 24(2002), pp. 4228-4233.
Synthesis of triple helix forming oligonucleotides with a phenanthroline moiety into the 3’-3’ inversion site of polarity
ESPOSITO, VERONICA;GALEONE, ALDO;MAYOL, LUCIANO;OLIVIERO, GIORGIA;RANDAZZO, ANTONIO;VARRA, MICHELA
2002
Abstract
A protocol for the synthesis of triplex forming oligonucleotides containing a chelating molecule in the 3'-3' inversion site of polarity is reported. A number of 16-mers have been synthesized and UV spectroscopy employed to evaluate the stability of their triple helix complexes with the pertinent double-strand oligonucleotide targets.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
