The reaction of 39,59-di-O-acetylthymidine with [Pt(PPh3)4] and KCl yielded a platinum(II) complex where the platinum is co-ordinated to the nucleobase through the N3 atom. In a similar reaction 1-methylthymine (1-MeThy) furnished the complex cis-[PtCl(1-MeThy)(PPh3)2], whose structure was determined by spectroscopic data and single crystal X-ray diffraction. When 1-MeThy was treated with [Pt(PPh3)4] in the absence of chloride ions the complex trans-[Pt(OH)(1-MeThy)(PPh3)2] was obtained.
Synthesis of platinum (II) complexes of thymidine (Thy) and 1-methylthymine (MeThy); crystal structure of cis-[PtCl(PPh3)2(3-MeThy)] / DE NAPOLI, Lorenzo; R., Iacovino; A., Messere; Montesarchio, Daniela; Piccialli, Gennaro; Romanelli, Alessandra; Ruffo, Francesco; M., Saviano. - In: JOURNAL OF THE CHEMICAL SOCIETY DALTON TRANSACTIONS. - ISSN 0300-9246. - ELETTRONICO. - 12:(1999), pp. 1945-1949. [10.1039/A901459D]
Synthesis of platinum (II) complexes of thymidine (Thy) and 1-methylthymine (MeThy); crystal structure of cis-[PtCl(PPh3)2(3-MeThy)]
DE NAPOLI, LORENZO;MONTESARCHIO, DANIELA;PICCIALLI, GENNARO;ROMANELLI, ALESSANDRA;RUFFO, FRANCESCO;
1999
Abstract
The reaction of 39,59-di-O-acetylthymidine with [Pt(PPh3)4] and KCl yielded a platinum(II) complex where the platinum is co-ordinated to the nucleobase through the N3 atom. In a similar reaction 1-methylthymine (1-MeThy) furnished the complex cis-[PtCl(1-MeThy)(PPh3)2], whose structure was determined by spectroscopic data and single crystal X-ray diffraction. When 1-MeThy was treated with [Pt(PPh3)4] in the absence of chloride ions the complex trans-[Pt(OH)(1-MeThy)(PPh3)2] was obtained.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
