The synthesis of thymidine dimers 5a,b containinga chiral carbon in the propionamide internucleosidiclinkage is described. These new epimeric dimers were incorporated in oligodeoxyribonucleotides and the melting temperature (Tm) with complementary DNA and RNA as well as the resistence of the single strand against exonuclease were determined.
Synthesis of Thymidine Dimers Containing a New Internucleosidic Amide Linkage and their Incorporation into Oligodeoxyribonucleotides / DE NAPOLI, Lorenzo; Iadonisi, Alfonso; Montesarchio, Daniela; Varra, Michela; Piccialli, Gennaro. - In: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. - ISSN 0960-894X. - ELETTRONICO. - 5:(1995), pp. 1647-1652. [10.1016/0960-894X(95)00279-3]
Synthesis of Thymidine Dimers Containing a New Internucleosidic Amide Linkage and their Incorporation into Oligodeoxyribonucleotides
DE NAPOLI, LORENZO;IADONISI, ALFONSO;MONTESARCHIO, DANIELA;VARRA, MICHELA;PICCIALLI, GENNARO
1995
Abstract
The synthesis of thymidine dimers 5a,b containinga chiral carbon in the propionamide internucleosidiclinkage is described. These new epimeric dimers were incorporated in oligodeoxyribonucleotides and the melting temperature (Tm) with complementary DNA and RNA as well as the resistence of the single strand against exonuclease were determined.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
