Treatment of 3',5'-di-O-acetyl-2'-deoxyinosine 1 with PPh(3)-CCl4 in the presence of catalytic 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) afforded 6-chloro-9-(2'-deoxy-3'.5'-di-O-acenyl-beta-D-ribofuranosyl)purine 3. Use of an excess of DBU gave the new dimeric bipurine 5 (90%) which proved to be a useful intermediate for obtaining, in one step. [N-15-1]-2'-deoxyinosine.
Reaction of 3',5'-di-O-acetyl-2'-deoxyinosine with the chlorinating agent PPh3/CCl4: synthesis of the 6-chloroderivative and of a new base linked dimer, useful intermediate to 15N-1- labelled 2'-deoxyinosine / DE NAPOLI, Lorenzo; A., Messere; Montesarchio, Daniela; Piccialli, Gennaro; C., Santacroce; Varra, Michela. - In: JOURNAL OF THE CHEMICAL SOCIETY. PERKIN TRANSACTIONS. I. - ISSN 0300-922X. - ELETTRONICO. - 8(1994), pp. 923-925. [10.1039/p19940000923]
Reaction of 3',5'-di-O-acetyl-2'-deoxyinosine with the chlorinating agent PPh3/CCl4: synthesis of the 6-chloroderivative and of a new base linked dimer, useful intermediate to 15N-1- labelled 2'-deoxyinosine
DE NAPOLI, LORENZO;MONTESARCHIO, DANIELA;PICCIALLI, GENNARO;VARRA, MICHELA
1994
Abstract
Treatment of 3',5'-di-O-acetyl-2'-deoxyinosine 1 with PPh(3)-CCl4 in the presence of catalytic 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) afforded 6-chloro-9-(2'-deoxy-3'.5'-di-O-acenyl-beta-D-ribofuranosyl)purine 3. Use of an excess of DBU gave the new dimeric bipurine 5 (90%) which proved to be a useful intermediate for obtaining, in one step. [N-15-1]-2'-deoxyinosine.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
