Studies on the solid-phase synthesis of cyclic oligonucleotides using CPG or polyacrylamide as a solid matrix are reported. The former support was shown to be not suitable at all since it does not prevent intermolecular couplings. On the other hand, polyacrylamide resin allows the synthesis of medium-size cyclic oligonucleotides provided that the appropriate functionalization of the polymer is used
Solid phase synthesis of cyclic oligodeoxyribonucleotides intermolecular versus intramolecular coupling / DE NAPOLI, Lorenzo; Galeone, Aldo; Mayol, Luciano; A., Messere; Montesarchio, Daniela; Piccialli, Gennaro; C., Santacroce. - In: GAZZETTA CHIMICA ITALIANA. - ISSN 0016-5603. - STAMPA. - 121:(1991), pp. 505-508.
Solid phase synthesis of cyclic oligodeoxyribonucleotides intermolecular versus intramolecular coupling.
DE NAPOLI, LORENZO;GALEONE, ALDO;MAYOL, LUCIANO;MONTESARCHIO, DANIELA;PICCIALLI, GENNARO;
1991
Abstract
Studies on the solid-phase synthesis of cyclic oligonucleotides using CPG or polyacrylamide as a solid matrix are reported. The former support was shown to be not suitable at all since it does not prevent intermolecular couplings. On the other hand, polyacrylamide resin allows the synthesis of medium-size cyclic oligonucleotides provided that the appropriate functionalization of the polymer is usedI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
